Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Concepts and Directions in Redox Signaling Research
Discussion Leaders: Tobias Dick (German Cancer Research Center (DKFZ), Germany) and Kate Carroll (The Scripps Research Institute, USA)
7:40 pm - 8:20 pm
Toren Finkel (University of Pittsburgh, USA)
"Redox Signaling Meets Aging Biology"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Navdeep Chandel (Northwestern University, USA)
"Functional Genomic Screens to Uncover Redox Biology"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Tools for Redox Signaling Research
Discussion Leaders: Vsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia) and Andreas Meyer (University of Bonn, Germany)
9:00 am - 9:20 am
Huiwang Ai (University of Virginia, USA)
"Fluorescent Protein Based Biosensors for Compartmentalized Redox Parameters"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yi Yang (East China University of Science and Technology, China)
"Genetically Encoded Sensors for Visualizing Redox Metabolism in Living Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Jing Yang (National Center for Protein Sciences, Beijing, China)
"Direct Mapping of oxiPTMs in Proteomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Hadley Sikes (Massachusetts Institute of Technology, USA)
"Understanding and Monitoring the Action of Redox-Directed Cancer Therapeutics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yimon Aye (Cornell University / Weill Cornell Medicine, USA)
"Swiss Army Man: A Single Molecule that Simultaneously Profiles and Decodes Precision Protein-Cysteine Signaling Axes in Living Systems"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Valentin Cracan (Harvard Medical School / Massachusetts General Hospital, USA)
"Genetically Encoded Tools for Compartment-Specific Manipulation of NAD+/NADH and NADP+/NADPH in Living Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jiska van der Reest (Cancer Research UK Beatson Institute, United Kingdom)
"Proteome-Wide Analysis of Cysteine Oxidation Using SICyLIA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Xiaojing Yang (University of Illinois at Chicago, USA)
"Dynamic Crystallography Studies of Protein Thiol Switches"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Yvonne Janssen-Heininger (University of Vermont, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanisms of Redox Signaling in Aging
Discussion Leaders: Michael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland) and Rodney Levine (National Institutes of Health, USA)
6:00 pm - 6:20 pm
Vadim Gladyshev (Brigham and Women's Hospital / Harvard Medical School, USA)
"Selenium, Redox and Aging"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Ursula Jakob (University of Michigan, USA)
"Effects of Developmental ROS on Stress Resistance and Lifespan"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Kitai Kim (Memorial Sloan-Kettering Cancer Center, USA)
"Homeostatic Redox Balance and Epigenetic Changes During the Cellular Transition to Stem Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Helena Cocheme (MRC London Institute of Medical Sciences, United Kingdom)
"Redox Regulation of Autophagy Extends Lifespan in Drosophila "
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Giuseppe Filomeni (Danish Cancer Society Research Center, Denmark)
"GSNOR Links S-Nitrosylation to the Mitochondrial Theory of Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Dysregulation of Redox Signaling in Age-Related Disease
Discussion Leaders: Carola Neumann (Magee-Womens Research Institute, USA) and Arne Holmgren (Karolinska Institutet, Sweden)
9:00 am - 9:20 am
Marcus Conrad (Helmholtz Zentrum Muenchen, Germany)
"Ferroptosis Mechanisms and Pharmacological Tractability in Degenerative Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Albert Van Der Vliet (University of Vermont, USA)
"Dynamic Redox-Based Control of Tyrosine Kinase Signaling in Health and Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Thomas Michel (Cardiovascular Division, Brigham and Women's Hospital / Harvard Medical School, USA)
"Probing In Vivo Oxidant Pathways in the Cardiovascular System Using Chemogenetic Approaches"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Cristina Furdui (Wake Forest School of Medicine, USA)
"Integrated Redox Analysis of Head and Neck Cancer Reveals New Opportunities for Diagnosis and Treatment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Kumar Somyajit (University of Copenhagen, Denmark)
"Redox-Controlled Boundaries of Physiological and Pathological Responses at a Replication Fork"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Igor Asanovic (Medical University of Vienna, Austria)
"Characterization of PYROXD1, a Novel Redox-Redulator of tRNA Splicing"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Evanna Mills (Dana-Farber Cancer Institute / Harvard Medical School, USA)
"Accumulated Succinate Controls Mitochondrial ROS Production to Activate Adipose Tissue Thermogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Bernd Moosmann (Johannes Gutenberg University Mainz, Germany)
"The Dark Side of the Moon: Membrane Thiols Cause Premature Aging In Vivo "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pharmacological Manipulation of Redox Signaling
Discussion Leaders: Yvonne Janssen-Heininger (University of Vermont, USA) and Ana Denicola (University of the Republic, Uruguay)
6:00 pm - 6:20 pm
Elias Arner (Karolinska Institutet, Sweden)
"Anticancer Potential of Cell-Specific Redox Effects by Drugs Targeting Thioredoxin Reductase 1"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Michael Murphy (MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom)
"Manipulating Mitochondrial Thiol Redox Status In Vivo "
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Amit Singh (Indian Institute of Science, India)
"Redox Diversity Breeds Drug Tolerance in Mycobacterium tuberculosis "
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Sharon Campbell (University of North Carolina at Chapel Hill, USA)
"Redox Regulation of the Oncogenic KRas G12C Mutant"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jonathan Ghergurovich (Princeton University, USA)
"Targeting the oxPPP: Discovery and Characterization of Cell-Active G6PD Inhibitors"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Thiol Peroxidases in Redox Signaling
Discussion Leaders: Elizabeth Veal (Newcastle University, United Kingdom) and Luis Netto (Universidade de Sao Paulo, Brazil)
9:00 am - 9:20 am
Leslie Poole (Wake Forest School of Medicine, USA)
"Disulfide Formation Kinetics of Two-Cysteine Peroxiredoxins and a Model for Peroxide Sensing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Christine Winterbourn (University of Otago, Christchurch, New Zealand)
"Multiple Possibilities for Peroxiredoxin Involvement in Redox Signaling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Tobias Dansen (University Medical Center Utrecht, The Netherlands)
"Peroxiredoxins Facilitate the Oxidation of Thiols in Target Proteins Through Distinct Mechanisms"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Elena Hidalgo (Pompeu Fabra University, Spain)
"Using Fission Yeast to Study Oxidative Stress in Toxicity and Signalling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
W. Todd Lowther (Wake Forest School of Medicine, USA)
"Novel Structural Insights into the Rearrangements Required for the Disulfide-Bond Formation Step of Peroxiredoxins"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Bruce Morgan (University of Kaiserslautern, Germany)
"A Potential Role for H2 O2 and Peroxiredoxins in Regulating Cellular Time-Keeping"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Paul Pace (Centre for Free Radical Research, University of Otago, Christchurch, New Zealand)
"Exploring a Putative Redox Relay Between Peroxiredoxins and the Cytoskeletal-Regulatory Protein CRMP2"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mehmet Berkmen (New England BioLabs, USA)
"Using Peroxidases to Enhance Oxidative Folding in E. coli "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Oxidative Stress Resistance and Damage Control
Discussion Leaders: Luise Krauth-Siegel (Heidelberg University, Germany) and Joris Messens (Redox Signaling Lab, Center for Structural Biology, VIB, Vrije Universiteit Brussel, Belgium)
6:00 pm - 6:20 pm
Gilles Charvin (Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), GIE-CERBM, CNRS, France)
"Integration of Hydrogen Peroxide Stress in Single Dividing Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Michael Davies (University of Copenhagen, Denmark)
"Disulfide Bonds: A Crucial and Neglected Target for Biological Oxidants"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Marcel Deponte (TU Kaiserslautern, Germany)
"Mother Nature Invented Glutathione: But Why So Much? Principles and Open Questions in Glutathione Metabolism"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Dana Reichmann (The Hebrew University of Jerusalem , Israel)
"Profiling of Redox-Dependent Heterogeneity in Single Cells"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Emily Flashman (University of Oxford, United Kingdom)
"Enzyme-Catalysed Cysteine Oxidation and Its Role in Plant Flood Tolerance"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Redox Control Across Membranes and Compartments
Discussion Leaders: Johannes Herrmann (University of Kaiserslautern, Germany) and Michel Toledano (French Alternative Energies and Atomic Energy Commission (CEA), France)
9:00 am - 9:20 am
Carolyn Sevier (Cornell University, USA)
"Molecular Mechanisms to Maintain Cellular Redox Homeostasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Neil Bulleid (University of Glasgow, United Kingdom)
"Reversing Redox Modifications in the Mammalian Endoplasmic Reticulum"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Keith Blackwell (Harvard Medical School, USA)
"Regulation of Oxidative and Proteasomal Stress Responses at the ER"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gyorgy Hajnoczky (Thomas Jefferson University, USA)
"Redox Nanodomain Mediated Signaling at ER-Mitochondrial Contact Sites"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Deborah Fass (Weizmann Institute of Science, Israel)
"Physiological Functions of Golgi and Extracellular Disulfide Bond Formation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Roberto Sitia (Vita-Salute San Raffaele University, Italy)
"Regulation of Thiol-Mediated Protein Quality Control in the Early Secretory Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jan Riemer (University of Cologne, Germany)
"A Switch-off Mechanism to Protect the Mitochondrial Glutathione Pool from Oxidative Stress"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Reactive Sulfur Species and Their Biomedical Relevance
Discussion Leaders: Beatriz Alvarez (University of the Republic, Uruguay) and Milos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
6:00 pm - 6:20 pm
James Mitchell (Harvard University, USA)
"The Role of Hydrogen Sulfide in Endothelial Cell Energy Metabolism and Angiogenesis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Peter Nagy (National Institute of Oncology, Budapest, Hungary)
"Speciation of Reactive Sulfur Species and Their Reactions with Alkylating Agents: Do We Have Any Clue About What Is Present Inside the Cell?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jon Fukuto (Sonoma State University, USA)
"The Chemical Biology of Hydropersulfides and Related Polysulfides: Possible Cellular Protectants"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Emilia Kouroussis (Institut de Biochimie et Génétique Cellulaires (IBGC), University of Bordeaux, France)
"Waves of Protein Persulfidation: From Signalling to Aging"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Iria Medraño Fernandez (Vita-Salute San Raffaele University, Italy)
"Aquaporin-8 Gating by Persulfidation: A Spillway to Route H2 O2 Signalling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure