Mechanisms and Consequences of Redox Signaling

Post-translational modification of protein thiols can rapidly and reversibly alter protein function and plays key roles in fundamental physiological processes and drug pharmacology. This Gordon Conference will center its discussion around the range of emerging redox-based signaling pathways employed to sense and offset redox changes to support cell function or target cells for destruction. A key challenge is understanding how redox signaling mechanisms facilitate communication between molecules, organelles, cells, and organisms to initiate different outcomes. Significant emphasis will be placed on the various sources and targets of thiol modification, and the range of consequences for the upregulation or dampening of redox signaling across species and in relation to disease pathologies.

This interdisciplinary, international conference provides an important venue for the free exchange of ideas among chemists, biochemists, molecular and cell biologist, physiologists, and clinicians working on various aspects of redox biology and medicine. Greater than 25% of the presentation slots will be reserved for trainees, junior investigators, and those newer to the field that have had more limited opportunities to interact at in-person meetings. Any attendee with an accepted abstract will have the opportunity (but is not required) to present a poster speed talk. We invite and welcome trainees, early and established career investigators, and those from underrepresented groups with an interest in redox signaling to attend this meeting to share their expertise and perspectives, to stimulated collaborations, and foster their interest and engagement in redox-signaling research.