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Thiol-Based Redox Regulation and Signaling (GRS)

Gordon-Kenan Research Seminar

Probing the Thiol Proteome

July 28 - 29, 2012
Chairs Erika Bechtold and Matthieu Depuydt
Bates College
2 Andrews Road
Lewiston, Maine, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Thiol-Based Redox Regulation & Signaling is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to promote social and intellectual interaction among young investigators who share a common interest in thiol oxidation, oxidative stress, and chemical toxicology. Topics will range from chemical biology and proteomics to cell signaling and regulation, with an emphasis on reversible thiol oxidation as a modulator of protein function.

Related Meeting

This GRS will be held in conjunction with the "Thiol-Based Redox Regulation and Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmNavigating your Scientific Career Path
Discussion Leader: Vyacheslav Labunskyy (Harvard Medical School)
Panelists: Erin Whalen (Novartis), Bita Nakhai (NIA/NIH) and Cristina Furdui (Wake Forest Baptist Medical Center)
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmNew Approaches to Examine Thiol Oxidation and Nitration
Discussion Leader: Jenna DuMond (Wake Forest/ Winston-Salem State University)
7:30 pm - 7:45 pmRanjan Banerjee (Boston College)
"A Chemical Genetic Approach to Develop Cysteine Reactive Anti-cancer Agents"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmSusan Mitroka (Wake Forest)
"Reactions of HNO with biological targets: Modification of cysteine thiols"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmYu Zhao (Washington State University)
"The development of chemical tools for hydrogen sulfide (H2S) research"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmKatja Menger (MRC Mitochondrial Biology Unit)
"OxICAT, a method to identify reversibly oxidized cysteine residues in aging flies"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJulie Reisz (Wake Forest School of Medicine)
"Improved strategies for the labeling and detection of cysteine sulfenic acid using small cyclic and linear enolate probes"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmUthpala Seneviratne (Massachusetts Institute of Technology)
"Cellular S-Nitrosoglutathione (GSNO) capture by triphenylphosphine-thioesters, quantitation and probing lower abundance low molecular weight nitrosothiols by Mass Spectrometry"
9:25 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amProtein Response to Oxidation and Nitration
Discussion Leaders: Vyacheslav Labunskyy (Harvard Medical School) and Koen Van Laer (Vrije Universiteit Brussel)
9:00 am - 9:15 amTomas Gustafsson (Karolinska Institutet)
"The thioredoxin system of Bacillus anthracis as a potential target in novel antimicrobial therapies"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amCharles Knutson (Massachusetts Institute of Technology)
"Transnitrosation of Thioredoxin by S-Nitrosoglutathione"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJorge Alegre-Cebollada (Columbia University)
"S-Glutathionylation regulates protein mechanics"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amLionel Tarrago (Brigham and Women's Hospital, Harvard Medical School)
"Unfolded Oxidized Proteins as Preferred Substrates for Methionine Sulfoxide Reductases"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amKatleen Denoncin (Université Catholique de Louvain)
"Redox Regulation of the Periplasmic L-arabinose Binding Protein"
10:35 am - 10:40 amDiscussion
10:40 am - 10:55 amMaxwell Darch (University of South Carolina)
"Glutathione Compartmentalization and Exchange Between the Cytosol and Mitochondria"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmThe Role of Environmental and Cellular Oxidants in Signaling and Disease
Discussion Leader: Christopher Switzer (NIH/NCI)
1:30 pm - 1:45 pmBindu Paul (Johns Hopkins University)
"Roles of the Histidine Thiol, Ergothioneine, in Cytoprotection"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmMatthew Child (Stanford School of Medicine)
"Toxoplasma DJ-1; a Model for Reactive Oxygen Species Modulation of Calcium Signaling"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmEsther Jortzik (Justus Liebig University Giess)
"S-glutathionylation as a regulatory protein modification in malaria parasites"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Contributors

Conference Links

Conference History Thiol-Based Redox Regulation and Signaling
Additional Fee Info

Thiol-Based Redox Regulation and Signaling
July 14 - 19, 2024


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