Thiol-Based Redox Regulation and Signaling (GRS)

Gordon Research Seminar

Probing the Thiol Proteome

July 19 - 20, 2014
Chairs and

Conference Description

The Gordon Research Seminar on Thiol-Based Redox Regulation & Signaling is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to provide an inviting social and intellectual atmosphere for the exchange, presentation, and discussion of new/unpublished data on cutting edge topics by young investigators with comparable experience and education that share a common interest in thiol oxidation, oxidative stress, and chemical toxicology. The scientific focus will range from topics associated with chemical biology and proteomics to cell signaling and regulation, with a common emphasis on reversible thiol oxidation as a modulator of protein function.

Related Meeting

This GRS will be held in conjunction with the "Thiol-Based Redox Regulation and Signaling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

SATURDAY
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmCharacterization of Protein Response to Oxidation
Discussion Leader: Nelmi Devarie Baez (Wake Forest University School of Medicine)
3:15 pm - 3:27 pmHolly Bryan (University of Liverpool)
"The Chemical Mechanism of Action of CDDO-Me - A Potent Inducer of the Nrf2 Cell Defense Pathway"
3:27 pm - 3:30 pmDiscussion
3:30 pm - 3:42 pmZhenbo Cao (Univeristy of Glasgow)
"Lack of an Efficient Endoplasmic Reticulum-Localized Recycling System Protects Peroxiredoxin IV from Hyperoxidation"
3:42 pm - 3:45 pmDiscussion
3:45 pm - 3:57 pmAri Zeida (University of Buenos Aires)
"Molecular Basis of Thiol Oxidation by Peroxides: Aqueous Solution and Peroxiredoxins"
3:57 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session I
5:30 pm - 7:30 pmProtein Response to Oxidation and Nitration
Discussion Leaders: Esther Jortzik (Justus Liebig University Giess) and Mirko Sobotta (German Cancer Research Center)
5:30 pm - 5:45 pmLaura Botello-Morte (University of Zaragoza)
"Disulfide Reductase Activity and Redox Properties of the Global Regulator FurA: A Novel CXXC-Based Redox Sensor?"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:05 pmBrandan Pedre Perez (Vrije Universiteit Brussel)
"A Peroxidase of Corynebacterium glutamicum Shows Promiscuity in Thiol Redox Regulation"
6:05 pm - 6:10 pmDiscussion
6:10 pm - 6:25 pmJeremiah Keyes (Wake Forest University School of Medicine)
"Modulation of Erk Activity by Reversible Cysteine Oxidation"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:45 pmDeepthi Menon (Australian National University)
"Redox Modifications of Proteins: Glutathione Transferase Omega 1 (GSTO1-1) as a Deglutathionylase"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:05 pmLewis Tomalin (Newcastle University)
"A Kinetic Modeling Approach to Aid Our Understanding of Intracellular H2O2 Dynamics and Peroxiredoxin Hyperoxidation"
7:05 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmMarcel Van Lith (University of Glasgow)
"Monitoring Cellular Redox Status During Metabolic Changes Using Redox-Sensitive GFPs"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amRole of Environmental and Cellular Oxidants in Signaling and Disease
Discussion Leaders: Julie Reisz (Wake Forest University School of Medicine) and Jun Liu (University of Delaware)
9:00 am - 9:15 amJesalyn Bolduc (Wake Forest University School of Medicine)
"Determining the Molecular Basis for Human Prx1 and Prx2 Differential Susceptibility to Hyperoxidation and Inactivation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amMickael Briens (Institut de Biologie Moleculaire)
"Role of the Selenoprotein N in Redox Signaling Networks"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJade Mims (Wake Forest School of Medicine)
"Integrated Model for Radiation Induced Redox Signaling in Head and Neck Squamous Cell Carcinoma"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amEdward Chouchani (University of Cambridge)
"S-Nitrosation of a Cysteine Switch on Mitochondrial Complex I Protects from Acute Ischemia/Reperfusion Damage and Post Myocardial Infarction Heart Failure"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amAna Gomes Barata (German Cancer Research Center)
"H2O2 in Mitochondrial Function and Homeostasis"
10:35 am - 10:40 amDiscussion
10:30 am - 10:50 amMarieke Visscher (Universitair Medisch Centrum)
"Redox Regulation of the Tumor Suppressor p16"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmDeveloping Your Scientific Career
Discussion Leader: Inge Van Molle (VIB Structural Biology Research Center)
1:30 pm - 1:35 pmPanelist Introductions: Toren Finkel (National Institutes of Health), Michel Toledano (CEA, IBITECS, LSOC), and Elizabeth Veal (Newcastle University)
1:35 pm - 2:30 pmOpen Mentor Panel Discussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Contributors

Conference Links

Conference History Thiol-Based Redox Regulation and Signaling
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