Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Redox Signaling in Age-Related Disease
Discussion Leader: Evanna Mills (Dana-Farber Cancer Institute / Harvard Medical School, USA)
3:15 pm - 3:25 pm
Matthew Campbell (University of Washington, USA)
"Reducing Mitochondrial Oxidative Stress Reverses Age-Related Changes in Redox-Sensitive Post-Translational Modifications in Aged Muscle"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Grace Okoro (University of the West of England, Bristol, United Kingdom)
"Alcohol Increases Aβ Load Through Redox-Mediated Dysregulation of Mitochondrial Dynamics"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Leonardo Tanaka (Heart Institute, University of São Paulo, Brazil)
"Peri/Epicellular Protein Disulfide Isomerase-A1 Acts as an Upstream Organizer of Cytoskeletal Mechanoadaptation in Vascular Smooth Muscle Cells"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Novel Insights into Basic Thiol Biochemistry
Discussion Leaders: Brandan Pedre Perez (German Cancer Research Center (DKFZ), Germany) and Lia Randall (Universidad de la República, Uruguay)
5:30 pm - 5:45 pm
Kassi Stein (Massachusetts Institute of Technology, USA)
"Kinetic Modeling of Responses to H2 O2 Perturbations in the Mitochondria of Human Cells"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
David Young (VIB, Vrije Universiteit Brussel, Belgium)
"Structural Snapshots of H2 O2 Reduction by the Transcription Factor, OxyR"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Ari Zeida (Facultad de Medicina, Universidad de la Republica, Uruguay)
"Structural, Dynamical and Biochemical Characterization of the Catalytic Mechanism of the Methione Sulfoxide Reductases from Mycobacterium tuberculosis "
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Bruno Manta (New England Biolabs, Inc., USA)
"A Trypanothione-Dependent Glutaredoxin Connects the Orphan Pools of GSH to the Cellular Redox Metabolism in Trypanosomes"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Lucía Turell (Facultad de Ciencias, Universidad de la República, Uruguay)
"Glutathione Transferase Catalyzes the Addition of Glutathione to Nitro-Conjugated Linoleic Acid"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Ying Chen (Peking university, China)
"Chemoproteomic Profiling of Carbonylations in Ferroptosis by an Aniline-Derived Probe"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Redox Regulation of the Transcriptome and Epigenome
Discussion Leaders: Valentin Cracan (Harvard Medical School / Massachusetts General Hospital, USA) and Daria Ezerina (VIB, Vrije Universiteit Brussel, Belgium)
9:00 am - 9:15 am
Katelyn Dunigan (University of Alabama at Birmingham, USA)
"The Thioredoxin Reductase Inhibitor Auranofin Induces Heme Oxygenase-1 in Lung Epithelial Cells via Nrf2-Dependent Mechanisms"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Frances Evesson (Children's Medical Research Institute, The University of Sydney, Australia)
"PYROXD1: A Novel Oxidoreductase Underlying Congenital Myopathy and Essential for Murine Viability"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Paraskevi Kritsiligkou (German Cancer Research Center (DKFZ), Germany)
"Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
David McGarry (Cancer Research UK Beatson Institute, United Kingdom)
"Protein Thiol Oxidation in Tumor Cell Motility"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Beata Siemiatkowska (Max Planck Institute of Molecular Plant Physiology, Germany)
"Mass Spectrometry as a Tool for Understanding Plant Redox Regulation"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Joy Smith (King's College London, United Kingdom)
"Sulforaphane-Mediated Inhibition of SHP2 as a Potential Pharmacotherapy for Noonan Syndrome"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Your Scientific Career Path
Discussion Leader: Jesalyn Bolduc (Vrije Universiteit Brussel, Belgium)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:25 pm
Panel Discussion
Developing Your Scientific Career
Edward Chouchani (Harvard Medical School, USA)
Leslie Poole (Wake Forest School of Medicine, USA)
Tobias Dansen (University Medical Center Utrecht, The Netherlands)
2:25 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
