Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Novel Factors in Thiol Biochemistry
Discussion Leader: Ari Zeida (Facultad de Medicina, Universidad de la Republica, Uruguay)
3:15 pm - 3:25 pm
Martina Steglich (Universidad de la República, Uruguay)
"Catalysis of the Reaction Between Nitroconjugated Linoleic acid and Glutathione by Human Glutathione Transferases"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
Joseph Fakhoury (Indiana University, United States)
"Functional Asymmetry and Chemical Reactivity of CsoR Family Persulfide Sensors"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
Nathalia Rocco Machado (National Institutes of Health, United States)
"Activation of the Calcium/Calmodulin Dependent Kinase II (CaMKII) by Disulfide Formation"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Thiol-Redox Elements in Health and Disease
Discussion Leaders: Gaston Ofman (The University of Oklahoma Health Science Center, United States) and Anna Thompson (Georgia Institute of Technology, United States)
5:30 pm - 5:45 pm
Deanna Tiek (Northwestern University, United States)
"Cysteine depletion-induced ferroptosis in drug resistant glioblastoma"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Klaudia Galambos (National Institute of Oncology, Hungary)
"Reprogramming of hydrogen sulfide metabolism can support targeted therapy resistance in melanoma"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Sofia Vrettou (University Hospital of Cologne, Germany)
"S-Glutathionylation and S-Nitrosylation in Spinal Muscular Atrophy"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Hannah Rosenblatt (Stanford University, United States)
"Redox Regulation of Tissue Regeneration and the Injury Response"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Beatriz Silva (University of São Paulo (USP), Brazil)
"Thiol-peroxidase AhpC1 Confers Pseudomonas aeruginosa Pathogenicity Through Reduction of Oxidants Generated During Inflammation"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Boushra Bathish (University of Dundee, United Kingdom)
"TGF-ß vs Nrf2; Redox Signalling in Liver Fibrosis"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Tools to Monitor Thiol-Redox Modifications
Discussion Leaders: Dayana Benchoam (Universidad de la República, Uruguay) and Bianca Dempsey (University of Michigan, United States)
9:00 am - 9:15 am
Meg Shieh (Brown University, United States)
"Revisiting SSP4: a Comprehensive Analysis into the Fluorescent Probe and its Applications in Biological Systems for the Detection of Sulfane Sulfurs"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Eszter Petra Jurányi (Department of Molecular Immunology and Toxicolology, National Institute of Oncology, Hungary)
"Critical Re-investigations of Alkylation Reactions in Relation to the Detection of Per- and Polysulfide Species"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Lisa Knoke (Ruhr University Bochum, Germany)
"The Role of Glutathione in the Periplasm of Escherichia coli"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Laísa Quadros Barsé (Ruhr-Universität Bochum, Germany)
"How to Kill with Gold? Elucidating Auranofin's (AF) Mechanism of Action in Bacterial Cells"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Markus Waldeck-Weiermair (BRIGHAM AND WOMEN'S HOSPITAL, United States)
"Differential Receptor-Dependent Hydrogen Peroxide Signaling via Nox Isoforms in Vascular Endothelial Cells: Critical Roles for Rac1 and Modulation by Statins"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Siyang Ding (Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, Australia)
"DPANzine – a Novel Fluorescent Reporter for Protein Carbonylation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Navigating Your Scientific Career Path
Discussion Leader: Lucía Turell (Universidad de la República, Uruguay)
1:30 pm - 2:30 pm
Panel Discussion
Navigating Your Scientific Career Path
Yimon Aye (Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland)
Bruce Morgan (Universität des Saarlandes, Biochemie, Germany)
Ursula Jakob (University of Michigan, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes