Understanding Redox Processes and Cellular Consequences in Biomolecules and Whole Cells

July 13 - 14, 2024

Chairs

and

Rey Don Jaime Grand Hotel

Avinguda de l'Hotel

Castelldefels, Barcelona, Spain

Venue and Travel Information

Conference Description

The Thiol-Based Redox Regulation and Signaling GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Oxidative modifications of thiols and other functional groups are important in many cellular processes and imbalances in redox-associated pathways are often accompanied by the development of diseases and an altered cell viability. This meeting tries to cover different perspectives on oxidative (thiol) modifications generated by physiologically relevant oxidants and their cellular consequences in physiological and pathophysiological scenarios. Discussion topics will range from insides in thiol-based cellular redox signaling and regulation to lipid peroxidation and ferroptosis. Additionally, the focus will be on the development of novel tools to study thiol modifications and thiol-dependent processes.

Related Meeting

This GRS will be held in conjunction with the "Thiol-Based Redox Regulation and Signaling" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Lipids in Redox Biology Discussion Leaders: and
3:15 pm - 3:25 pm	"Human Glutathione Transferases Catalyze the Inactivation of Nitrooleic Acid"
3:25 pm - 3:30 pm	Discussion
3:30 pm - 3:40 pm	"2H-Thiopyran-2-Thione Sulfine and its Analogues: Unique Compounds For Converting H2S to HSOH/H2S2"
3:40 pm - 3:45 pm	Discussion
3:45 pm - 3:55 pm	"Effect of p-Benzoquinone, a Cigarette Smoke-Derived Component, on the Architecture of Red Blood Cell Membrane"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Cellular Redox Signaling and Regulation Discussion Leaders: and
5:30 pm - 5:40 pm	"Precision Persulfide Generation Provides Insight into the Mitochondrial Sulfane Sulfur Pool"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Thiol Based Defense Mechanisms of Mycobacterium Tuberculosis Against Hypochlorous Acid"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"Exploring Skeletal Muscle Cysteine Oxidation Shifts Immediately Post and in Recovery from Acute Exercise"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:25 pm	"Active Site Cysteine Positioning in a Trypanosoma Brucei Dual-Function Peroxiredoxin Enables Adaptation to a Parasitic Life Style"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"A 2-Cys Peroxiredoxin Confers Redox Sensitivity on a p38-Related MAPK by Dual Independent Mechanisms"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Mediator Complex Subunit 16 (MED16): Its Physiological Role and Redox-dependent Regulations"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Novel Modification of Peroxiredoxin 3 After Mitochondrial Oxidative Stress"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"A New Role for Cu/Zn Superoxide Dismutase in Fe/S Biogenesis"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Tools to Monitor Thiol-Redox Modifications Discussion Leaders: and
9:00 am - 9:10 am	"Exploring Endogenous Modulators of Protein Persulfidation Using a Novel Quantitative Assay"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Deciphering Subcellular Redox Dynamics in AML: Insights from Genetically Encoded Sensors and Live-Cell Imaging"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"An Approach to the Study of Single Cell Redox Dynamics by Using Cancer Patient-Derived Organoids (PDOs) and Compartment-Specific Genetically-Encoded Redox Biosensors"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"An Electrochemical Method to Switch, Monitor, and Control Mucus Thiol-Disulfide in a Gut Model System"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Understanding the Architecture of Human Redox-Relay Complexes"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"The Anticancer Compounds Auranofin, TRi-1 and TRi-2 have Distinct Cytotoxicity Profiles with Regards to Thioredoxin Reductase Inhibition"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Exploring the Implications of a Novel Silver-Ruthenium-Based Surface Coating on the Bacterial Redox Homeostasis"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Inter-Compartmental H₂O₂ Fluxes and their Regulation by Scavengers, Transporters and Signaling Cascades Affect Cell Fitness"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Navigating Your Career Path: How to Make Science More Inclusive Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Navigating Your Scientific Career Path
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by 1R13 ES036444-01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Thiol-Based Redox Regulation and Signaling

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