| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Whither (Molecular) Electron Microscopy? |
| Discussion Leader: Kenneth Downing (Lawrence Berkeley National Laboratory) |
| 7:30 pm - 7:40 pm | Welcome and Introduction |
| 7:40 pm - 8:15 pm | Keiichi Namba (Osaka University)
"High resolution 3D imaging of dynamic molecular assemblies" |
| 8:15 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:10 pm | Ray Stevens (The Scripps Research Institute)
"New scientific opportunities in the high throughput protein crystallography-electron microscopy interface" |
| 9:10 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | High Resolution of Structures with High Symmetry |
| Discussion Leader: Tim Baker (University of California, San Diego) |
| 9:00 am - 9:10 am | Introduction and overview |
| 9:10 am - 9:35 am | Hans Hebert (Karolinska Institute)
"Atomic model of microsomal glutathione transferase 1 from two different crystal forms" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Tamir Gonen (Harvard Medical School)
"Water and lipid molecules in the electron crystallographically determined structure of the aquaporin-0 membrane junction" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:10 am | Coffee Break / Group Photo |
| 11:10 am - 11:35 am | Phoebe Stewart (Vanderbilt University)
"CryoEM structure at 9 Å resolution of an adenovirus vector targeted to hematopoietic cells" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Yuyao Liang (UT - Houston Med. School)
"Near atomic resolution reconstruction of large viruses" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Software and Analysis Tools |
| Discussion Leader: Jose-Maria Carazo (Centro Nacional de Biotechnologia, Madrid) |
| 7:30 pm - 7:40 pm | Introduction and overview |
| 7:40 pm - 8:05 pm | Pawel Penczek (University of Texas Houston Medical School)
"Philtering improves alignment in cryo-EM" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Jorge Navaza
"On the reconstruction of spherical particles using symmetry adapted functions. A full reciprocal space formulation" |
| 8:40 am - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Chandrajit Bajaj (University of Texas)
"Geometric processing for structure elucidation in three dimensional electron microscopy" |
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Better Resolution of Structures with Low Symmetry |
| Discussion Leader: Melissa Jurica (University of California, Santa Barbara) |
| 9:00 am - 9:10 am | Introduction and overview |
| 9:10 am - 9:35 am | Roger Craig (University of Massachusetts)
"Atomic model of the 'OFF' state of a myosin filament determined by cryo-EM" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Thomas Marlovits (Yale University)
"The type III protein secretion machinery: structure, assembly and conformational changes" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:10 am | Coffee Break |
| 11:10 am - 11:35 am | Helen Saibil (Birkbeck College)
"Single particle studies of protein machinery" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Christian Spahn (Universitätsklinikum Charité, Berlin)
"Visualization of secondary structure elements in cryo-EM maps of ribosomal complexes at sub-nanometer resolution" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Poster Presentations and Discussion I |
| Discussion Leader: Teresa Ruiz (University of Vermont) |
| TBN (8 speakers, 10 min presentation and 5 min discussion each) |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecular and Cellular Tomography |
| Discussion Leader: Manfred Auer (Lawrence Berkeley National Laboratory) |
| 9:00 am - 9:10 am | Introduction and overview |
| 9:10 am - 9:35 am | Jun Liu (Florida State University)
"3-D Structure of myosin-V in the inactive state determined by cryo-electron tomography of 2-D arrays" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Maryann Martone (UC San Diego)
"Unraveling the structural and molecular complexity of the nervous system using correlated 3D light and electron microscopic imaging" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:10 am | Coffee Break |
| 11:10 am - 11:35 am | Allison van de Meene (Arizona State University)
"Electron tomography of cryofixed, resin embedded cells of the cyanobacterium Synechocystis sp. PCC 6803" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Friedrich Foerster (MPI Martinsried)
"Studying macromolecules in situ by cryoelectron tomography in conjunction with single-particle averaging" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| 7:30 pm - 9:30 pm | Instrumentation and Specimen Preparation Advances |
| Discussion Leader: Bridget Carragher (The Scripps Research Institute) |
| 7:30 pm - 7:40 pm | Introduction and overview |
| 7:40 pm - 8:05 pm | Max Haider (CEOS, Heidelberg)
"Contrast enhancement by means of new electron optical devices" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Scott Stagg (The Scripps Research Institute)
"The Structure of a Minimal COPII Cage: A Case Study in Automation" |
| 8:40 pm - 8:50 am | Discussion |
| 8:50 pm - 9:15 pm | Ashraf Al-Amoudi (Université de Lausanne)
"Cryoelectron Microscopy of vitreous sections of native biological samples" |
| 9:15 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Applications in Building and Refining Hybrid Structures |
| Discussion Leader: Chris Akey (Boston University) |
| 9:00 am - 9:10 am | Introduction and overview |
| 9:10 am - 9:35 am | Petr Leiman (Purdue University)
"Similarities in the capsid structure of dsDNA tailed bacteriophages point to a common ancestry" |
| 9:35 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Werner Kühlbrandt
"Synergies between electron microscopy and x-ray crystallography in studying high-resolution structures and molecular mechanisms of membrane proteins" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:10 am | Coffee Break |
| 11:10 am - 11:35 am | Doryen Bubeck (Harvard Medical School)
"An unconventional approach to solving the structure of a poliovirus-receptor-membrane complex" |
| 11:35 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Michael Schmid (Baylor College of Medicine)
"F-Actin and Scruin Structural models in the context of the acrosomal bundle" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Poster Presentations and Discussion II |
| Discussion Leader: Masahide Kikkawa (University of Texas, Southwestern Medical Center) |
| TBN (8 speakers, 10 min presentation and 5 min discussion each) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
