Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Structure among the Chaos: Using Cellular Tomography to Study Mitochondrial Behavior
Discussion Leader: Gregor Weiss (ETH Zurich, Switzerland)
3:45 pm - 3:55 pm
Introduction by Discussion Leader
3:55 pm - 4:20 pm
Danielle Grotjahn (Scripps Research, USA)
"Structure Among the Chaos: Using Cellular Tomography to Study Mitochondrial Behavior"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Putting Structures in Context
Discussion Leader: Bronwyn Lucas (University of Massachusetts Medical School, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
Paula Navarro (Massachusetts General Hospital / Harvard Medical School, USA)
"In Situ Architecture and Dynamics of Bacterial Cell Division Dictate Polar Shape"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Qiu Yu Huang (University of Massachusetts Medical School, USA)
"Quantitative Structural Analysis of Influenza Virus by Cryo-Electron Tomography and Convolutional Neural Networks"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Steffen Klein (Heidelberg University, Germany)
"In Cellulo Cryo-CLEM Reveals the Antiviral Effect of IFITM3 by Arresting the Hemifusion State During Influenza A Virus Membrane Fusion"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Jie Yang (University of Wisconsin-Madison, USA)
"Exploring In Situ Viral Infection with Multi-Modal Cryogenic Correlative FLM-FIB/SEM for Vitrified Mammalian Cells"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Michael Wozny (MRC Laboratory of Molecular Biology, United Kingdom)
"In Situ Cryo-Electron Tomography of the ER-Mitochondria Encounter Structure in Yeast"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Sven Klumpe (Max-Planck-Institute for Biochemistry, Germany)
"In Situ Structural Analysis of the Nuclear Pore Complex in Drosophila melanogaster Egg Chambers"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Christian Zimmerli (Max Planck Institute for Biophysics, Germany)
"Membrane Tension Regulates Nuclear Pore Diameter"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Understanding Structural Dynamics
Discussion Leader: James Chen (New York University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:20 am
Anna Talyzina (Northwestern University, USA)
"Structure of the Human Mediator-Bound Transcription Preinitiation Complex"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Dominik Herbst (University of California, Berkeley, USA)
"Structure of the Human SAGA Coactivator Complex"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Maximilian Sauer (University of Washington, USA)
"Broadly Neutralizing β-Coronavirus Antibodies that Protect Against SARS-CoV-2 Variants of Concern by Blocking the Fusion Machinery"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Sophie Gobeil (Duke Human Vaccine Institute, USA)
"Emerging SARS-CoV-2 Variants: How Natural Mutations Impact the Structure, Conformation and Antigenicity of the Spike Protein"
10:05 am - 10:10 am
Discussion
10:10 am - 10:20 am
Chen Sun (Purdue University, USA)
"Ab Initio Helical Indexing in Real Space Without the Need for Fourier Layer Lines"
10:20 am - 10:25 am
Discussion
10:25 am - 10:35 am
Anthony Schuller (Massachusetts Institute of Technology, USA)
"The Cellular Environment Shapes the Nuclear Pore Complex Architecture"
10:35 am - 10:40 am
Discussion
10:40 am - 10:50 am
Peter Kirchweger (Weizmann Institute of Science, Israel)
"CSTET: A Window into the Cell"
10:50 am - 10:55 am
Discussion
10:55 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How to Make the Most Out of Scientific Networking
Discussion Leader: Philipp Erdmann (Human Technopole, Italy)
1:30 pm - 2:15 pm
Panel Discussion
How to Make the Most out of Scientific Networking
Danielle Grotjahn (Scripps Research, USA)
Daniela Nicastro (University of Texas Southwestern Medical Center, USA)
Sharon Wolf (Weizmann Institute of Science, Israel)
2:15 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
