| 1. Sunday PM: Advances in structure and function of fibrinolytic proteins |
- Paul Declerck, Discussion leader, Univ. of Leuven - Overview and Novel features of PAI-1 inactivation
- Edwin Madison, Corvas Intl., Inc., - Revisiting Catalysis by Chymotrypsin Family Serine Proteases Using Peptide Substrates and Inhibitors with Unnatural Main Chains
- Wolfram Bode, Max-Planck Institude - tPA and plasmin: Structural basis of activation and activity
- Paul Curmi, Univ.of New South Wales - Probing the mechanism of PAI-2 by x-ray crystallography
| 2. Monday AM: Fibrinolysis and matrix biology |
- David Loskutoff, Discussion leader, Scripps Research Institute - Regulation of cell adhesion by PAI-1
- Cynthia Peterson, Vanderbilt University - New insights into the structure of vitronectin
- William Fay, University of Michigan - Analysis of vitronectin knockout mice
- Klaus Preissner, Max-Planck-Institut - Vitronectin interactions with fibrinolytic components in the context of cell adhesion
| 3. Monday PM: Fibrinolytic receptors and their role in cellular function |
- Steve Gonias, Discussion leader, University of Virginia - LRP and modulation of uPAR
- Francesco Blasi, H.S. Raffaele Mol.. Genetics. - uPAR signalling
- Harold Chapman, Univ. of California, San Francisco. - Structural basis for the interaction between uPAR and Integrins
| 4. Tuesday AM: Neurobiology and fibrinolytic proteins |
- Sid Strickland, Discussion leader, SUNY, Stony Brook - The roles of tPA in the central and peripheral nervous system
- Joachim Herz, Southwestern Medical Cntr. - The LDL receptor gene family: lipids, proteases and brain development
- David Lomas, Univ. of Cambridge - Serpin polymerisation and dementia
- Peter Sonderegger, Univ. of Zurich - Extracellular proteolysis at the synapse: role in synaptic function and plasticity
- Guojun Bu, Washington University - Role of tPA receptor LRP in hippocampal long-term potentiation
| 5. Tuesday PM: New therapeutic proteins in stroke therapy |
- Desire Collen, Discussion leader, Univ. of Leuven - Overview
- Nobuo Nagai, Univ. of Leuven - Thrombolysis in stroke: a double edged sword
- Manuel Yeppes, Georgetown Univ. - Neuroserpin in stroke
- J. Zivin, Univ. of California, San Diego - Stroke Thrombolysis
| 6. Wednesday AM : Metalloproteinases and plasminogen activators in physiology and pathology |
- Sharon Stack, Discussion leader, Northwestern Univ. - Integrin regulation of PA and MMP expression
- Steven Shapiro, Washington University, St. Louis - MMPs and PAs in Vascular Disease
- Yves Declerck Childrens Hospital Los Angeles - Serine and Metalloproteinases in neuroblastoma metastasis
- Desire Collen, Univ. of Leuven - Role of u-PA and MMP-9 in cardiac rupture and myocardial healing after myocardial infarction
| 7. Wednesday PM: Late breaking developments (selected poster presentations) |
- Jay Degen and Paul Declerck, Discussion leaders
- N. Agnes - Mice aorta ring assay: A new approach of the molecular genetics of angiogenesis
- Troels Wind - Isolation and characterization of PAI-1 binding peptides from phage displayed repertoires
- Supurna Ghosh - A functional link between ß1 integrin aggregation, uPA expression and uPAR localization in premalignant oral epithelial cells
- Steven Pirie-Shepherd - Multiple antiangiogenic molecules generated from the hemostatic system by tumor-mediated proteolysis
- Hau Kwaan - PAI-1 may promote tumor growth through inhibition of apoptosis
- Linda Robbie - The leucocyte contribution to endogenous thrombolysis
- Tor Ny - Studies of collagen type-II induced arthritis in uPA and plasminogen deficient mice
- E. Angles-Cano - Small apo(a) isoforms confer to lipoprotein(a) high antifibrinolytic activity
- Philippe Nantermet - Non-peptidic, urea based thrombin receptor antagonists
| 8. Thursday AM: Angiogenesis and angiostatin |
- Dan Lawrence, Discussion leader, American Red Cross - PAI-1 and angiogenesis
- Don Davidson, Abbot Laboratories - Angiostatin
- Philip Hogg, Univ. of New South Wales - Initiation of angiostatin formation by phosphoglycerate kinase
- Katherine Hajjar, Cornell Univ. - Annexin II and angiogenesis
- S. Green EntreMed, Inc - TFPI in angiogenesis
| 9. Thursday PM: Fibrinolytic system in tumor progression |
- Jay Degen, Discussion leader, Children's Hospital Res. Fnd. - Role of fibrinogen in tumor invasion
- David Ginsburg, Howard Hughes Medical Institute - PAI-2 and cancer
- Jean-Michel Foidart, Univ. of Liege - Animal models of vascularization
|
