| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Molecular Analysis of Structure and Function |
| Discussion Leader: Ed Madison (Corvas Intl.) |
| 7:30 pm - 8:10 pm | Russell Doolittle (University of California, San Diego)
"The Structure of Fibrinogen/Fibrin" |
| 8:10 pm - 8:50 pm | Robin Carrell (University of Cambridge)
"The Serpin-Protease Complex" |
| 8:50 pm - 9:30 pm | Ed Madison (Corvas Intl.)
"Membrane-Associated Serine Proteases" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Neurobiology and Hemostasis-related Proteases |
| Discussion Leader: Sid Strickland (Rockefeller University) |
| 9:00 am - 9:35 am | Sid Strickland (Rockefeller University)
"Role of the PA System in Neurodegeneration and Repair" |
| 9:35 am - 10:10 am | Lindsey Miles (Scripps Research Institute)
"tPA and Chromaffin Cell Function"" |
| 10:10 - 10:45 am | Coffee Break and Conference Photo |
| 10:45 am - 11:20 am | Dudley Strickland (American Red Cross Holland Laboratory)
"Protease Receptors and Alzheimer's Disease |
| 11:20 am - 11:55 pm | Martin Citron (Amgen Inc.)
"b-Secretase and Alzheimer's Disease" |
| 11:55 am - 12:30 pm | Elizabeth Powell (University of Pittsburgh)
"u-PAR and HGF/SF mediate forebrain development" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Role of the PA System in Tissue Repair and Fibrosis |
| Discussion Leader: David Loskutoff (Scripps Research Institute) |
| 7:30 pm - 8:10 pm | Doug Vaughan (Vanderbilt University)
"Plasminogen Activation and Vascular Fibrosis" |
| 8:10 pm - 8:50 pm | Richard Simon (University of Michigan)
"The Plasminogen Activation System in Pulmonary Fibrotic Diseases" |
| 8:50 pm - 9:30 pm | Jorge Bezerra (University of Cincinnati)
"Plasminogen Activation and Liver Repair" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Serine Protease / Metalloprotease Axis |
| Discussion Leader: Stephen Weiss (University of Michigan) |
| 9:00 am - 9:35 am | Stephen Weiss (University of Michigan)
"Role of Serine Proteases and Metalloproteases in Angiogenesis" |
| 9:35 am - 10:10 am | Gabriele Bergers (University of California, San Francisco)
"Molecular mechanisms underlying stage-specific regulation of angiogenesis" |
| 10:10 - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Roger Lijnen (University of Leuven)
"Matrix Metalloproteases and Obesity" |
| 11:20 am - 11:55 pm | Leif Lund (Finsen Laboratory, Copenhagen)
"MMP-9, Plasmin and Tissue Repair" |
| 11:55 am - 12:00 pm | Kenn Holmback (National Institutes of Health)
"Genetic Analyses of MT1-MMP Function" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Thrombolysis and Vessel Wall Disease |
| Discussion Leader: Nuala Booth (University of Aberdeen, UK) |
| 7:30 pm - 8:10 pm | David Dichek (University of Washington)
"uPA and atherosclerosis" |
| 8:10 pm - 8:50 pm | Dan Eitzman (University of Michigan)
"PAI in Atherosclerosis" |
| 8:50 pm - 9:30 pm | Aernout Luttun (University of Leuven)
"Proteases, Growth Factors and their Inhibitors in Vessel Wall Disease" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Genetic Interactions and Phenotypic Modifiers |
| Discussion Leader: David Ginsburg (University of Michigan) |
| 9:00 am - 9:40 am | David Ginsburg (University of Michigan)
"Secondary Genetic Modifiers of Single-gene Mutations" |
| 9:40 am - 10:20 am | Frank Castellino (Notre Dame University)
"Single and Combined Deficits in Protein C, fXI and fVII" |
| 10:20 - 10:50am | Coffee Break |
| 10:50 am - 11:30 am | Shaun Coughlin (University of California, San Francisco)
"Interplay between Protease Activated Receptors and Coagulation Factors" |
| 11:30 am - 12:10 pm | Hardy Weiler (Blood Research Institute, Milwaukee)
"Thrombin/Thrombomodulin in Development" |
| 12:10 am - 12:30 pm | Brief Communication
Karen List (NIH and the Finsen Laboratory, Copenhagen)
"The pro-uPA activator, Matriptase/MT-SP1, is required for epidermal barrier function, hair follicle development, and thymocyte survival" |
| 12:30 pm | Lunch |
| 1:00 pm - 5:00 pm | Field Trip to Getty Museum or Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Hot topics from Abstracts |
| Discussion Leaders: Jay Degen (University of Cincinnati)
James Quigley (Scripps Research Institute)
Steven Rosenberg (University of California) |
| 7:30 pm - 7:45 pm | Ralf-Peter Czekay (Scripps Research Institute)
"Mechanism of cell detachment by PAI-1" |
| 7:45 pm - 8:00 pm | Uwe Jerke (Delbrücke Center for Molecular Medicine, Berlin, Germany)
"Urokinase-dependent human vascular smooth muscle cell adhesion requires selective vitronectin phosphorylation by ecto-protein kinase CK2" |
| 8:00 pm - 8:15 pm | Lars Kjøller (MRC Lab.for Mol. Cell Biol. and the Finsen Laboratory)
"Urokinase plasminogen activator receptor induces cytoskeletal rearrangements and increased cell motility through vitronectin-dependent activation of the small GTPase, RAC" |
| 8:15 pm - 8:30 pm | Aiwu Zhou (University of Cambridge, UK)
"Structural study of PAI-1 binding to the somatomedin B domain of vitronectin" |
| 8:30 pm - 8:45 pm | Mitch Olman (University of Alabama)
"Urokinase receptor binding site blockade on integrin a-chains abrogates human lung fibroblast adhesion and migration" |
| 8:45 pm - 9:00 pm | Walter Laug (University of Southern California)
"Pegylated human and mouse uPA-peptide 1-48 inhibits orthotopic brain tumor growth in nude mice" |
| 9:00 pm - 9:15 pm | Jaap Neels (Scripps Research Institute)
"Changes in PAI-1 gene expression during angiogenesis in an in vivo model of adipogenesis" |
| 9:15 pm - 9:30 pm | Allart Stoop (University of California, San Francisco)
"Plasma kallikrein-mediated plasminogen activation is required for adipocyte differentiation" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Angiogenesis and Tumor Biology |
| Discussion Leader: Dan Lawrence (Red Cross Holland Laboratories) |
| 9:00 am - 9:35 am | Dan Lawrence (Red Cross Holland Laboratories)
"PA and PAI-1 in Angiogenesis" |
| 9:35 am - 10:10 am | Joe Palumbo (University of Cincinnati)
"Plasminogen/Fibrinogen in Tumor Dissemination" |
| 10:10 - 10:45 am | Coffee Break |
| 10:45 am - 11:20 am | Toni Antalis (American Red Cross Holland Laboratory)
"A profile of serine protease expression by human endothelial cells
during tubule morphogenesis and angiogenesis" |
| 11:20 am - 11:55 pm | Michael Pepper
"Proteolysis in angiogenesis and lymphangiogenesis" |
| 11:55 am - 12:30 pm | Francesco Blasi (DIBIT, Milano, Italy)
"Mechanisms of uPAR Signalling" |
| 12:30 pm | Lunch |
| 1:30 pm | Business Meeting |
| 2:00 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Farewell Reception |
| 6:00 pm | Banquet |
| 7:30 pm - 9:30 pm | uPAR, Membrane Events and Signaling |
| Discussion Leader: Steve Gonias (University of Virginia) |
| 7:30 pm - 8:10 pm | Steve Gonias (University of Virginia)
"uPAR and Signal Transduction Pathways" |
| 8:10 pm - 8:50 pm | Hal Chapman (University of California, San Francisco)
"uPAR - Integrin Interactions" |
| 8:50 pm - 9:30 pm | Harvey Herschman (University of California, Los Angeles)
"uPAR and Neuronal Cell Differentiation" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
