Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Modeling Cell-Cell Interactions Governing Tissue Repair and Disease
The keynote speakers Frederic de Sauvage (Genentech, USA) and Elaine Fuchs (Rockefeller University, USA) are world experts in intestine and skin epithelial biology, respectively. Their expertise includes every major developmental signaling pathway, including Wnt, BMP, and Notch. This session highlights the vision of this GRC, because the same signaling pathways regulate stem cells in different epithelial tissues and have important consequences in disease in epithelial tissues.
Discussion Leader: Jane Visvader (The Walter and Eliza Hall Institute of Medical Research, Australia)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
Elaine Fuchs (Rockefeller University, USA)
"Coping with Stress: Skin Stem Cells in Action"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Frederic de Sauvage (Genentech, USA)
"Tumor Cell Plasticity as a Challenge for Targeted Therapies"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Imaging and Single Cell Approaches
Discussion Leader: Jason Rock (Boston University School of Medicine, USA)
9:00 am - 9:20 am
Fernando Osorio (Boston Children's Hospital, USA)
"Whole-Organism Lineage Tracing and Transcriptional Mapping by Combinatorial Genome Editing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Katie Cockburn (Yale School of Medicine, USA)
"Capturing Principles of Stem Cell Coordination by Imaging in Live Mice"
9:50 am - 10:00 am
Discussion
10:00 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:05 am
Tannishtha Reya (University of California, San Diego, USA)
"Imaging Stem Cells in Cancer Progression and Therapy Resistance"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Jose Ordovas-Montanes (Broad Institute, MIT / Ragon Institute of MGH, MIT and Harvard, USA)
"Barrier Dysfunction in Human Type 2 Immunity Arises from an Altered Basal Progenitor Cell State and Reduced Epithelial Cellular Diversity"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tudorita (Doina) Tumbar (Cornell University, USA)
"Stem Cells Remodel Their Microenvironment and Coordinate It with Epigenome Reprograming for Proper Hair Follicle Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kara McKinley (University of California, San Francisco, USA)
"Cellular Aspect Ratio and Division Mechanics Pattern Cell Lineages in the Intestinal Epithelium"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Caleb Dawson (Walter and Eliza Hall Institute, Australia)
"The Mammary Epithelium Programs Resident Ductal Macrophages that Drive Breast Remodelling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Carla Kim (Boston Children's Hospital, USA) and Jane Visvader (The Walter and Eliza Hall Institute of Medical Research, Australia)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diverse Cell Types in Supporting Roles
Discussion Leader: Carla Kim (Boston Children's Hospital, USA)
7:30 pm - 7:50 pm
Emi Nishimura (Tokyo Medical and Dental University, Japan)
"Stem Cell and Niche Dynamics in Aging Skin"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Yaron Fuchs (Technion - Israel Institute of Technology, Israel)
"Thy1.2 Marks a Distinct Stem Cell Population that Contributes to Epidermal Homeostasis and Repair"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Michael Rendl (Icahn School of Medicine at Mount Sinai, USA)
"Fate Before Function: Dermal Condensate Precursors Are Specified Before Hair Follicle Progenitor Niche Formation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Tushar Desai (Stanford University, USA)
"Dynamic Integration of Diverse Niche Cues Determines Lung Alveolar Stem Cell Activity"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Developmental Pathways Regulating Adult Tissues
Discussion Leader: Leanne Jones (University of California, Los Angeles, USA)
9:00 am - 9:20 am
Wolfram Goessling (Dana-Farber Cancer Institute, USA)
"Regulation of Liver Growth and Regeneration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Norbert Perrimon (Harvard Medical School, USA)
"Roles of Calcium Signaling in Stem Cell Proliferation and Differentiation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Melanie Koenigshoff (University of Colorado Denver, USA)
"Wnt Signaling in the Adult Lung: Progenitor Cell Plasticity and Repair"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Indrayani Waghmare (Vanderbilt University, USA)
"Dally-Like Differentially Regulates Wnt Ligands in Drosophila Germarium to Promote Germline Stem Cell Maintenance and Differentiation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Li Xin (University of Washington, USA)
"Regulation of Prostate Tissue Homeostasis by Wnt"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kim Jensen (University of Copenhagen, Denmark)
"Tracing the Origin of Intestinal Epithelial Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Stijn De Langhe (University of Alabama at Birmingham, USA)
"Mesenchymal-Epithelial Fgf10-Fgfr2b Signaling Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells After Bleomycin Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Intersections of Epithelial Development and Disease
Discussion Leader: Rongwen Xi (National Institute of Biological Sciences, China)
7:30 pm - 7:50 pm
Michele De Luca (University of Modena and Reggio Emilia, Italy)
"Combined Cell and Gene Therapy of JEB Shed Light on Human Epidermal Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Tianliang Sun (Novartis Institute for Biomedical Research, Novartis AG, Switzerland)
"Axin2+ Pericentral Hepatocytes in Homeostasis, Regeneration and Tumour Formation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Alexander Nikitin (Cornell University, USA)
"Stem Cells of the Female Reproductive Tract"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Michael Shen (Columbia University Medical Center, USA)
"Progenitor Cells and the Origin of Prostate Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cell Interactions
Discussion Leader: Alexander Nikitin (Cornell University, USA)
9:00 am - 9:20 am
Marcia Haigis (Harvard Medical School, USA)
"Roles for Mitochondria in Cell Proliferation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ophir Klein (University of California, San Francisco, USA)
"Diverse Regenerative Strategies of Mammalian Epithelial Stem Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Joo-Hyeon Lee (University of Cambridge, United Kingdom)
"Stem Cells and Their Dynamic Niche in Lung Regeneration and Repair"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Jason Rock (Boston University School of Medicine, USA)
"Immune-Epithelial Interactions in Lung Regeneration"
10:55 am - 11:05 am
Discussion
11:05 am - 11:15 am
Rumela Chakrabarti (University of Pennsylvania, USA)
"Notch Ligand Dll1 Mediates Crosstalk Between Mammary Stem Cells and the Macrophageal Niche"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
Carla Rothlin (Yale University, USA)
"Death Begets a New Beginning"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Judith Agudo (Dana-Farber Cancer Institute, USA)
"Quiescent Stem Cells Evade Immune Surveillance"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Rania Dagher (MedImmune, USA)
"IL-33-ST2 Axis Governs Airway Macrophage Differentiation and Their Regenerative Functions of Epithelial Niche"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
DNA Repair and Aging in Niches
Discussion Leader: Marcia Haigis (Harvard Medical School, USA)
7:30 pm - 7:50 pm
Heinrich Jasper (Genentech, Inc., USA)
"Age-Related Loss of Stem Cell Function: Lessons from Drosophila "
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Nalle Pentinmikko (University of Helsinki, Finland)
"Age-Induced Expression of Notum in the Stem Cell Niche Attenuates Regenerative Potential of Intestinal Epithelium"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Leanne Jones (University of California, Los Angeles, USA)
"The Role of Occluding Junctions in Regulating Stem Cell Behavior and Intestinal Aging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Carien Niessen (University of Cologne, Germany)
"Cell Adhesion and Polarity in Epithelial Barrier Formation, Maintenance and Turnover"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic and Molecular Regulation of Tissues and Their Niche
Discussion Leader: Valerie Gouon-Evans (Boston University, USA)
9:00 am - 9:20 am
Omer Yilmaz (Koch Institute for Integrative Cancer Research, MIT, USA)
"Endogenous Metabolites as Regulators of Intestinal Stem Cell Fate"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rongwen Xi (National Institute of Biological Sciences, China)
"Maintenance of Tissue Stem Cell Identity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Valerie Horsley (Yale University, USA)
"What Is a Fibroblast, Anyway?"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Sandra Ryeom (University of Pennsylvania School of Medicine, USA)
"Lung Fibrosis and the Role of Endothelial Derived-Thrombospondin-1"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Alena Moiseenko (Justus-Liebig University Giessen, Germany)
"Cellular and Molecular Characterization of the Mesenchymal Niche for Bronchiolar Epithelial Progenitor Cells After Naphthalene Injury in Mice"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ya-Chieh Hsu (Harvard University, USA)
"Beyond Goosebumps: Interactions Between the Hair Follicle, the Arrector Pili Muscle, and the Sympathetic Nerve During Development and Hair Follicle Regeneration"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Nikolaos Pantelireis (Imperial College London, United Kingdom)
"Modelling Mesenchymal Regulation of the Hair Follicle Stem Cell Niche"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Engineering Niches
Discussion Leader: Ophir Klein (University of California, San Francisco, USA)
5:30 pm - 5:50 pm
David Tuveson (Cold Spring Harbor Laboratory, USA)
"Pancreatic Cancer Heterogeneity"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Valerie Gouon-Evans (Boston University, USA)
"Contribution of Liver Progenitor Cells to Liver Regeneration After Acute and Chronic Injury"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Jill Goldstein (Harvard University, USA)
"In Situ Modification of Stem Cell Genomes in the Blood and Skeletal Muscle"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Ya-Wen Chen (Columbia University Medical Center, USA)
"Generation of a Three-Dimensional Lung Organoid from Human Pluripotent Stem Cells and Its Applications"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure