| Sunday Evening: | Embryonic Wound Repair and Regeneration |
Chair: Paul Martin, University College London
- Paul Martin: Parallels between wound healing and morphogenesis in the embryo
- Alejandro Sánchez Alvarado, Carnegie Institution, Washington: A functional genomics approach to the study of regeneration in Schmidtea mediterranea
- Alex Nechiporuk, University of Utah, Salt Lake City / Harvard Medical School, Boston: Molecular mechanisms of zebrafish fin regeneration
- Jeremy Brockes, University College London: Proliferation of post-mitotic cells in urodele limb regeneration
| Monday Morning: | Development and Repair of the Lung |
Chair: Jeffrey Davidson, Vanderbilt University, Nashville
- Jeffrey Davidson: Novel mechanisms of pulmonary scarring
- Patricia Segarini, Fibrogen, South San Francisco: The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is a receptor for connective tissue growth factor (CTGF)
Conference Photo, Coffee Break
- Dean Sheppard, University of California, San Francisco: Integrin-mediated TGF-b activation in lung injury
- Steve Shapiro, Washington University, St. Louis: Elastases in lung destruction and repair
- Robert Mason, University of Colorado, Denver: KGF in alveolar type II cell differentiation and lung repair
| Monday Evening: | Cellular Differentiation |
Chair: Frederick Grinnell, University of Texas, Dallas
- Frederick Grinnell: Fibroblasts, myofibroblasts, and the collagen matrix contraction model
- Giulio Gabbiani, University of Geneva: Mechanisms of myofibroblast modulation
- Manuela Martins-Green, University of California, Riverside: The CXC chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure
- Michael Detmar, Harvard Medical School, Boston: Control of angiogenesis during wound repair
- Norbert Fusenig, German Cancer Research Center, Heidelberg: Paracrine regulation of epidermal regeneration
| Tuesday Morning: | Growth Factor Biology |
Chair: Judy Abraham, Chiron Corporation, Emeryville
- Judy Abraham: Growth factors in wound healing
- Michael Klagsbrun, Harvard Medical School, Boston: Neuropilins are mediators of angiogenesis
- Kari Alitalo, University of Helsinki: Growth factor regulation of angiogenesis and lymphangiogenesis
Coffee Break
- Clive Dickson, Imperial Cancer Research Fund, London: Epithelial-mesenchymal signaling through FGFR2-IIIb
- David Ornitz, Washington University, St. Louis: Regulation of lung development and regeneration by FGF-9
- Georg Brunner, University of Munster: Latent TGF-b activation in wound repair
- Toshikazu Kondo, Kanazawa University, Japan: Accelerated wound healing in TNF receptor p55 knockout mice
| Tuesday Evening: | Cellular Signaling In Vitro and In Vivo |
Chair: Anita Roberts, NIH, NCI, Bethesda
- Anita Roberts: Smad3 - a key mediator of effects of TGF-b in fibrosis
- Alain Mauviel, Hôpital Saint-Louis, Paris: Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
- Rolf Kemler, Max-Planck-Institute of Immunobiology, Freiburg: E-cadherin and b-catenin in morphogenesis
- Eberhard Hildt, Robert-Koch-Institute, Berlin: Integrity of c-Raf-1 kinase is essential for the TNF-a dependent activation of NFkB
- Brigitte Galliot, University of Geneva: Genetic control of hydra head-regeneration
| Wednesday Morning: | Cell-matrix Receptors and Proteinases |
Chair: Richard Clark, SUNY at Stony Brook
- Richard Clark: Design of a 'smart' matrix for recalcitrant wounds
- Jeff Hubbell, ETH Zürich: Modified fibrin gels in tissue repair
Coffee Break
- Cornelia Mauch, University of Cologne: The snake venom metalloproteinase Jararhagin functions as a matrix signal for fibroblasts similar to fibrillar type I collagen
- Reinhard Fässler, University of Lund: Cell adhesion during mouse development
- Zena Werb, University of California, San Francisco: The role of proteinases in epithelial development, repair and pathology
- Alice Beare, University of Manchester: Impaired wound healing in the collagenase resistant mouse
| Wednesday Evening: | Inflammation (and Business Meeting) |
Chair: Joe Leibovich, New Jersey Medical School, Newark
- Joe Leibovich: Novel pathways regulating VEGF expression in macrophages
- Jay Heinecke, Washington University, St. Louis: Regulation of matrix metalloproteinase activity by oxidants
- Jing Zhu, Cornell University, New York: Proepithelin binds SLPI: Implications for innate immunity and wound healing
- Sabine Werner, ETH Zürich: Keratinocyte growth factor: Its role in epithelial repair and cytoprotection
| Thursday Morning: | Cell Migration |
Chair: William Parks, Washington University, St. Louis
- William Parks: Proteolytic mechanisms in migration
- Rick Horwitz, University of Virginia, Charlottesville: Steps and directions in cell migration
Coffee break
- Jean-Paul Thiery, Institut Curie, Paris: Regulation of cell migration in epithelial cells
- Pierre Coulombe, Johns Hopkins University, Baltimore: Keratins in epithelial cell migration
- Brian Pilcher, University of Texas, Dallas: Epsin 3 is a novel extracellular matrix-induced gene specific to wounded epithelia
- Nancy Boudreau, University of California, San Francisco: Gene transfer of Hox D3 accelerates healing in diabetic mice
| Thursday Evening: | Featured Speaker |
- Jeffrey Gordon, Washington University, St. Louis: Gnotobiotic mice and functional genomics: Delving into how nonpathogenic microbes shape gut epithelial biology
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