Tissue Repair and Regeneration

Gordon Research Conference

June 19 - 24, 2005
Chairs and
Vice Chair
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Description

The goal of this GRC will be to highlight the commonality of repair processes among various organs and tissues and to dissect their underlying molecular and cellular mechanisms. Furthermore, links between repair, regeneration, development, and disease will be addressed. Traditional "wound healing" topics such as connective tissue fibrosis will remain but we will also draw in some of the newer cell biology and genetic approaches in simple model organisms. Session topics include: growth factors and hormones in repair; regeneration; inflammation; neurorepair; epithelial cell migration; angiogenesis; and stem cell biology. Lectures will range from the most basic studies of tissue repair to applications in the clinic. As with previous Tissue Repair and Regeneration GRCs this will be an outstanding opportunity to learn about some of the newest and most exciting research in the field and should appeal to industrial and academic scientists as well as clinicians in the wound healing and regenerative medicine community.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and check-in
6:00 pm Dinner
7:30 pm - 7:40 pmWelcome and Introductions
Paul Martin, Judy Abraham & the GRC Staff
7:40 pm - 9:30 pm GENETICALLY TRACTABLE MODELS OF REPAIR
Discussion Leader: Paul Martin (University of Bristol)
7:50 pm - 8:20 pmMike Galko (Stanford University)
Wound healing in Drosophila
8:20 pm - 8:50 pm Mike Redd (Cancer Research UK & University College London)
Inflammation studies in Zebrafish
8:50 pm - 9:20 pmHoward Chang (Stanford University)
Tumor as wound: Insights from diverse genomic approaches
9:30 pmWelcoming Reception
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pm CELL MIGRATION
Discussion Leader: Pierre Coulombe (Johns Hopkins)
9:10 am - 9:40 amPierre Coulombe (Johns Hopkins)
Keratins in development and repair
9:40 am - 10:10 amJames Nelson (Stanford University)
Molecular mechanisms of migration and adhesion
10:10 am - 10:30 amAnne Hocking (University of Washington)
Wnt signalling and hair regeneration during epithelial repair
10:30 am Coffee Break / Photo
11:00 am - 11:30 amBill Parks (University of Washington)
Functional cooperation of matrix, integrins, and MMPs in wound closure
11:30 am - 12:00 pmIlene Gipson (Schepens Eye Research Institute, Harvard Medical School)
Re-epithelialization studies in the eye
12:00 pm - 12:20 pmKimberly Mace (University of California, San Francisco)
The grainyhead transcription factor in epidermal development and repair
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmANGIOGENESIS
Discussion Leader: Catherine Nobes (University of Bristol)
7:30 pm - 8:00 pmHolger Gerhardt (Cancer Research UK)
Growth factor regulation of angiogenic sprouting
8:00 pm - 8:30 pmKairbaan Hodivala-Dilke (Cancer Research UK)
TGFbeta and integrins in wound angiogenesis
8:30 pm - 9:00 pmCatherine Nobes (University of Bristol)
Eph receptor / ephrin signalling
9:00 pm - 9:30 pmAnn Daugherty (Genentech, Inc)
Clinical development of VEGF for wound healing
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmINFLAMMATION
Discussion Leader: Joe Leibovich (New Jersey Medical School)
9:10 am - 9:40 amJoe Leibovich (New Jersey Medical School)
Inflammation recruitment signals
9:40 am - 10:10 amWilliam Muller (Weill Medical College of Cornell University)
Diapedesis
10:10 am - 10:30 amBrian Stramer (University of Bristol)
Live imaging and genetics of inflammation in Drosophila embryos
10:30 amCoffee Break
10:50 am - 11:20 amLuisa DiPietro (Loyola University Medical Center)
Chemokines, inflammation, and tissue repair
11:20 am - 11:50 amAlberto Visintin (University of Massachusetts Medical School)
Toll-like receptor regulation of inflammation
11:50 am - 12:10 pmMatthew Hardman (University of Manchester)
Macrophage migration inhibitory factor is a global regulator of wound healing
12:10 pm - 12:30 pmManuela Martins-Green (University of California, Riverside)
Inflammation, angiogenesis, and wound healing: potential roles of IL-8 and VEGF
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmREGENERATION
Discussion Leader: Ken Muneoka (Tulane University)
7:40 pm - 8:10 pmKen Muneoka (Tulane University)
Molecular regulators of mammalian digit tip regeneration
8:10 pm - 8:40 pm Shinji Makino (Harvard University)
Fin regeneration in zebrafish
8:40 pm - 9:00 pm Craig Crews (Yale University)
Radially discontinuous skin induces ectopic limb bud formation in the Axolotl
9:00 pm - 9:30 pmJ.C. Izpisua-Belmonte (Salk Institute)
Heart regeneration in Zebrafish
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGROWTH FACTORS IN REPAIR
Discussion Leader: Judy Abraham (Chiron Corporation)
9:10 am - 9:40 amSabine Werner (ETH Zurich)
Cytoprotective signaling pathways in wounded skin
9:40 am - 10:00 amPing Wei (Amgen Inc.)
KGF (palifermin): clinical application and beyond
10:00 am - 10:30 amJeffrey Davidson (Vanderbilt University)
CARP: a novel mediator of neovascularization
10:30 am Coffee Break
11:00 am - 11:20 amGary Grotendorst (Lovelace Respiratory Research Institute)
Connective tissue growth factor regulates lung development
11:20 am - 11:40 amBernard Thebaud (University of Alberta)
VEGF gene therapy promotes lung angiogenesis and repair
11:40 am - 12:00 pmTeresa Odorisio (Istituto Dermopatico dell'Immacolata, Rome)
Placenta growth factor accelerates wound healing in diabetic mice
12:00 pm - 12:30 pmJeff Hubbell (Swiss Federal Institute of Technology)
Bioactive cell invasion matrices for morphogen presentation: examples in skin and bone repair
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNEUROREPAIR
Discussion Leader: Ann Logan (University of Birmingham)
7:30 pm - 8:00 pm Ann Logan (University of Birmingham)
Growth factors in CNS repair
8:00 pm - 8:30 pmStephen Davies (Baylor College of Medicine)
Spinal cord scarring and axon regeneration
8:30 pm - 9:00 pmPatrick Anderson (University College London)
Nogo - studies in axon regeneration
9:00 pm - 9:30 pmLarry Benowitz (Children's Hospital, Boston)
Macrophage-derived molecules promote neuronal survival and axon regeneration following injury to the optic nerve
THURSDAY
7:30 am - 8:30 amBreakfast
9:00 am - 9:30 amBUSINESS MEETING
Leader: Jack Gauldie (McMaster University)
9:40 am - 12:30 pmFIBROSIS
Discussion Leader: Jack Gauldie (McMaster University)
9:50 am - 10:20 amJack Gauldie (McMaster University)
Regulation of chronic fibrogenesis: beyond TGFbeta
10:20 am Coffee Break
10:50 am - 11:20 amMark Ferguson (University of Manchester)
The biology of scarring and development of scar reducing pharmaceuticals
11:20 am - 11:50 am Snorri Thorgeirsson (National Cancer Institute, NIH)
Liver repair and regeneration
11:50 am - 12:20 pmPaul Noble (Yale University)
Regulation of Lung Fibrosis by CXCL10 and Syndecan-4
12:30 pm Lunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSTEM CELLS; CLINICAL APPLICATIONS
Discussion Leader: Paul Martin (University of Bristol)
7:40 pm - 8:10 pm Richard Bucala (Yale University)
Fibrocytes: Stem cells for tissue repair
8:10 pm - 8:40 pm Yann Barrandon (Swiss Federal Institute of Technology)
Epithelial stem cells and skin regeneration
8:40 pm - 9:30 pmMike Longaker (Stanford University)
Skeletal repair: from bench to clinic
9:30 pmFarewell Party
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 amDeparture

Contributors

Genzyme Corporation
Amgen, Inc.
Kaken Pharmaceutical Company, Ltd.
Genentech, Inc.
Smith & Nephew Wound Management (La Jolla)
Baxter Healthcare Corporation
National Institutes of Health

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