Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Progress in Stem and Progenitor Cell Biology in Tissue Regeneration
Discussion Leader: Valerie Horsley (Yale University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Ken Poss (Duke University, United States)
"Signal Control During Tissue Regeneration"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Stuart Forbes (University of Edinburgh, United Kingdom)
"Developing Cell Therapy for Liver Repair Whilst Circling the Plug Hole"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Tissue Repair and Regeneration
Discussion Leader: Matthew Ronshaugen (University of Manchester, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Alejandro Sanchez Alvarado (HHMI/Stowers Institute for Medical Research, United States)
"Understanding the Sources of Regenerative Capacities in Animals"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
B. Duygu Ozpolat (Washington University in St. Louis, United States)
"Platynereis dumerilii as a Germline Regeneration Model"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Emilio Oviedo Rivadeneira (University of Kentucky, United States)
"Cell Proliferation Drives Tissue Regeneration in Spiny Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mansi Srivastava (Harvard University, United States)
"Using a New Research Organism to Understand the Mechanisms and Evolution of Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Rachel Smith-Bolton (University of Illinois at Urbana-Champaign, United States)
"Regulation of Patterning and Cell Fate During Regeneration in Drosophila "
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
David Salvador-Garcia (King's College London, United Kingdom)
"Live Imaging of the Coordination of Coagulation, Inflammation and Wound Repair in Drosophila "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Keaton Schuster (New York University, United States)
"A Chordate Model for the Origins of Cardiac Regenerative Capacity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Mansi Srivastava (Harvard University, United States) and Tanya Shaw (King's College London, United Kingdom)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Metabolism and ROS in Healing
Discussion Leader: Philipp Niethammer (Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Enrique Amaya (University of Manchester, United Kingdom)
"Dr. Strangefoot or: How I Learned to Stop Worrying and Love Metabolism"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Kathy Gillen (Kenyon College, United States)
"Production of Reactive Oxygen Species Post-Amputation in the Annelid L. variegatus "
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sabine Werner (ETH Zurich, Switzerland)
"Cytoprotective Signaling Pathways in Tissue Repair and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Petra Kotzbeck (Medical University of Graz/JOANNEUM RESEARCH, Austria)
"Inflammation in Wounds Promotes Reversible Changes in Wound Metabolism"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Grace Curtis (Washington State University, United States)
"Pleiotropic Roles of Leptin Signaling in Xenopus Tail Tip Regeneration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunity and Infection in Repair
Discussion Leader: Luisa DiPietro (University of Illinois Chicago, United States)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Martin Guilliams (Ghent University and VIB, Belgium)
"Role of Hepatic Macrophages in Liver Regeneration and Development"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Judith Allen (University of Manchester, United Kingdom)
"Matrix Regulation by IL-13"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Mark Naven (University of Bristol, United Kingdom)
"Live Imaging the Wound Inflammatory Response and the Consequences of Disrupted Circadian Clocks"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Christopher Hernandez (UC San Francisco, United States)
"The Gut Microbiome and Musculoskeletal Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Holly Wilkinson (Hull York Medical School, United Kingdom)
"Long-read Microbiome Profiling Reveals New Insight into Chronic Wound Microbial Diversity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Rachel Kratofil (New York University Grossman School of Medicine, United States)
"A Monocyte-Leptin-Angiogenesis Pathway Critical for Repair Post-infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Chang-Ru Tsai (Baylor College of Medicine, United States)
"Hippo Deficient Cardiac Fibroblasts Regulate Heart Fibrosis and Inflammation via Colony-Stimulating Factor-1 (Csf1) Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Molly Klimak (Washington University in St. Louis, United States)
"Engineered Self-regulating Macrophages for Targeted Anti-inflammatory Drug Delivery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Engineering and Regenerative Medicine
Discussion Leader: Feini Qu (Washington University in St. Louis, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Joel Boerckel (University of Pennsylvania, United States)
"Mechanoregulation of Bone Development and Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Chris Erickson (University of Colorado, United States)
"A Timeseries Analysis of the Fracture Callus Extracellular Matrix Proteome During Bone Fracture Healing"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jeroen Eyckmans (Boston University, United States)
"Engineering Biomimetic Models of Soft Tissue Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Bing Xu (Brandeis University, United States)
"Transcytotic Intercellular Gelation Enables Cell Spheroids"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Leslie Gold (New York University School of Medicine, United States)
"Calreticulin Electrospun into Extracellular Matrix Nanofibers Functionally Synergize for Cellular Response that Enable Tissue Repair"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modelling Regeneration
Discussion Leader: Brian Stramer (King's College London, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Julia Cordero (University of Glasgow and CRUK Beatson Institute , United Kingdom)
"Reciprocal Stem Cell-Niche Interactions Influencing Intestinal and Microenvironmental Plasticity During Regeneration."
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
Yasmin Roye (Duke University, United States)
"Targeting the Extracellular Matrix to Repair Hyperglycemia-induced Glomerular Injury"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jenny Paupert (University of Toulouse, France)
"A Digital Model of Tissue Repair Identifies an Early and Transient Decrease in Fiber Linking as Sufficient to Unlock Regeneration in Adult Mammals"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Anish Vasan (Boston University, United States)
"Senescent-associated Extracellular Matrix Production and Delayed Wound Healing by Senescent Dermal fFbroblasts in a Biomimetic Injury Model"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Will Wood (University of Edinburgh, United Kingdom)
"Imaging Inflammation and Repair in Drosophila"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Hui Wang (National Institutes of Health, United States)
"Identifying the Source of Blastemal Cells During Zebrafish Larva Caudal Fin Regeneration"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Daniel Cohen (Princeton University, United States)
"Cellular Herding: Controlling Collective Cell Behaviors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kyle Lam (St. Michael's Hospital, Canada)
"Mechanical Control of Exosome Formation by Mesenchymal Stromal Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Signalling and Gene Regulation in Wound Healing and Regeneration
Discussion Leader: Brigitte Galliot (University of Geneva, Switzerland)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Katherine Gallagher (University of Michigan, United States)
"Epigenetic Reprogramming of Immune Cells Alters Wound Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Nadja Ring (Ludwig Boltzmann Gesellschaft, Austria)
"The p-RpS6-Zone as a Marker of the Healing Process"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Andrea Wills (University of Washington, United States)
"Decoding the Metabolic Requirements for Vertebrate Appendage Regeneration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Lorin Olson (Oklahoma Medical Research Foundation, United States)
"PDGFRa and TGFbR2 Promote Adipocyte Plasticity in Skin Wounds"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Thanh Hoang (University of Michigan, United States)
"Reprogramming Glial Cells to Regenerate Retinal Neurons"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tissue Scarring and Remodeling
Discussion Leader: Tanya Shaw (King's College London, United Kingdom)
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
Boris Hinz (St. Michael's Hospital and University of Toronto, Canada)
"A Touchy Subject: Fibroblast Activation in the Injured Lung"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
Ellen Pure (University of Pennsylvania, United States)
"Implications of Fibroblast Heterogeneity and Matrix Dynamics"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Deandra Belo de Freitas (King's College London, United Kingdom)
"Autocrine IL-6 drives Cell and Extracellular Matrix Anisotropy in Scar Fibroblasts"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Paul Martin (University of Bristol, United Kingdom)
"Live Imaging the Wound Inflammatory Response and its Consequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Thomas Fabre (Pfizer, United States)
"Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Thomas Kirk (QMUL, United Kingdom)
"Combined Transcriptome and Epigenome Profiling Reveal Regulators of Dermal Fibroblast State Switching"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Julia Mo (Columbia University, United States)
"Exploring Macrophage Driven ECM Remodeling and Cell Fate Crosstalk During Ligament Regeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Medicine and Clinical Strategies
Discussion Leader: Marjana Tomic-Canic (Miller School of Medicine, University of Miami, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Geoffrey Gurtner (University of Arizona, United States)
"Developing Small Molecule Therapeutics for Tissue Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Tatiana Sandoval-Guzmán (Technische Universität Dresden, Germany)
"Proteomic Profiling of Human Fingertip Regeneration: Insights from a Longitudinal Study."
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Rivkah Isseroff (University of California Davis, United States)
"Translating from Bench to Patient Without IP: A Shorter Path?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Joshua Tam (Massachusetts General Hospital, United States)
"Altered Physiology, Constitutive Activation of Wound-associated Phenotypes, and Inherently Delayed Healing in Volar Skin"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Fatima Rizvi (Boston University School of Medicine, United States)
"Liver Progenitor Cell Differentiation to Hepatocytes Restores Liver Function in Liver Injury Mouse Models"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
