Tissue Repair and Regeneration

Gordon Research Conference

From Model Organisms to Translational Science: Exploring How Tissues Repair and Regenerate

May 28 - June 2, 2023
Chair
Vice Chair
Colby-Sawyer College
541 Main Street
New London, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Tissue Repair and Regeneration GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Tissue Repair and Regeneration" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Progress in Stem and Progenitor Cell Biology in Tissue Regeneration
Discussion Leader:
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Signal Control During Tissue Regeneration"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Developing Cell Therapy for Liver Repair Whilst Circling the Plug Hole"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Tissue Repair and Regeneration
Discussion Leader:
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Understanding the Sources of Regenerative Capacities in Animals"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Platynereis dumerilii as a Germline Regeneration Model"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Cell Proliferation Drives Tissue Regeneration in Spiny Mice"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Using a New Research Organism to Understand the Mechanisms and Evolution of Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Regulation of Patterning and Cell Fate During Regeneration in Drosophila"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Live Imaging of the Coordination of Coagulation, Inflammation and Wound Repair in Drosophila"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Chordate Model for the Origins of Cardiac Regenerative Capacity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: and
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Metabolism and ROS in Healing
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Dr. Strangefoot or: How I Learned to Stop Worrying and Love Metabolism"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Production of Reactive Oxygen Species Post-Amputation in the Annelid L. variegatus"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cytoprotective Signaling Pathways in Tissue Repair and Cancer"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Inflammation in Wounds Promotes Reversible Changes in Wound Metabolism"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Pleiotropic Roles of Leptin Signaling in Xenopus Tail Tip Regeneration"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunity and Infection in Repair
Discussion Leader:
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Role of Hepatic Macrophages in Liver Regeneration and Development"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Matrix Regulation by IL-13"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Live Imaging the Wound Inflammatory Response and the Consequences of Disrupted Circadian Clocks"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"The Gut Microbiome and Musculoskeletal Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Long-read Microbiome Profiling Reveals New Insight into Chronic Wound Microbial Diversity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Monocyte-Leptin-Angiogenesis Pathway Critical for Repair Post-infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hippo Deficient Cardiac Fibroblasts Regulate Heart Fibrosis and Inflammation via Colony-Stimulating Factor-1 (Csf1) Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Engineered Self-regulating Macrophages for Targeted Anti-inflammatory Drug Delivery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Engineering and Regenerative Medicine
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Mechanoregulation of Bone Development and Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"A Timeseries Analysis of the Fracture Callus Extracellular Matrix Proteome During Bone Fracture Healing"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Engineering Biomimetic Models of Soft Tissue Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Transcytotic Intercellular Gelation Enables Cell Spheroids"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Calreticulin Electrospun into Extracellular Matrix Nanofibers Functionally Synergize for Cellular Response that Enable Tissue Repair"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modelling Regeneration
Discussion Leader:
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Reciprocal Stem Cell-Niche Interactions Influencing Intestinal and Microenvironmental Plasticity During Regeneration."
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Targeting the Extracellular Matrix to Repair Hyperglycemia-induced Glomerular Injury"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A Digital Model of Tissue Repair Identifies an Early and Transient Decrease in Fiber Linking as Sufficient to Unlock Regeneration in Adult Mammals"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"Senescent-associated Extracellular Matrix Production and Delayed Wound Healing by Senescent Dermal fFbroblasts in a Biomimetic Injury Model"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Imaging Inflammation and Repair in Drosophila"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Identifying the Source of Blastemal Cells During Zebrafish Larva Caudal Fin Regeneration"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Cellular Herding: Controlling Collective Cell Behaviors"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanical Control of Exosome Formation by Mesenchymal Stromal Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Signalling and Gene Regulation in Wound Healing and Regeneration
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Epigenetic Reprogramming of Immune Cells Alters Wound Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"The p-RpS6-Zone as a Marker of the Healing Process"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Decoding the Metabolic Requirements for Vertebrate Appendage Regeneration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"PDGFRa and TGFbR2 Promote Adipocyte Plasticity in Skin Wounds"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Reprogramming Glial Cells to Regenerate Retinal Neurons"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Tissue Scarring and Remodeling
Discussion Leader:
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"A Touchy Subject: Fibroblast Activation in the Injured Lung"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Implications of Fibroblast Heterogeneity and Matrix Dynamics"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Autocrine IL-6 drives Cell and Extracellular Matrix Anisotropy in Scar Fibroblasts"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Live Imaging the Wound Inflammatory Response and its Consequences"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Identification of a Broadly Fibrogenic Macrophage Subset Induced by Type 3 Inflammation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Combined Transcriptome and Epigenome Profiling Reveal Regulators of Dermal Fibroblast State Switching"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Exploring Macrophage Driven ECM Remodeling and Cell Fate Crosstalk During Ligament Regeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Medicine and Clinical Strategies
Discussion Leader:
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Developing Small Molecule Therapeutics for Tissue Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Proteomic Profiling of Human Fingertip Regeneration: Insights from a Longitudinal Study."
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Translating from Bench to Patient Without IP: A Shorter Path?"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Altered Physiology, Constitutive Activation of Wound-associated Phenotypes, and Inherently Delayed Healing in Volar Skin"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Liver Progenitor Cell Differentiation to Hepatocytes Restores Liver Function in Liver Injury Mouse Models"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure

Contributors

Research reported in this publication was supported by the National Institutes of Health under Award Number R13HD105314. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Tissue Repair and Regeneration (GRS)
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