Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Mechanoregulation of Regeneration
Discussion Leader: Chang-Ru Tsai (Baylor College of Medicine, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Joel Boerckel (University of Pennsylvania, United States)
"Mechanoregulation of Cellular Hypoxia During Bone Repair"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Models and Mechanisms of Repair and Regeneration
Discussion Leader: Alireza Savadipour (Washington University in St. Louis, United States)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
Anish Vasan (Boston University, United States)
"Senescent-Associated Extracellular Matrix Production and Delayed Wound Healing by Senescent Dermal Fibroblasts in a Biomimetic Injury Model"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Maya Ezzo (University of Toronto/St. Michael's Hospital, Canada)
"Myofibroblast Activation is Induced Through Intracellular Stress in a Calcium-Dependent Process Upon Acute Contact With Profibrotic Macrophages"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Neda Rashidi (Washington University in St. louis, United States)
"Modulation of Human Adipose Stem Cell Collagen Synthesis by Mechanosensing of Substrate Architecture Through the Piezo1 Ion Channel"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Robyn Allen (University of Kentucky, United States)
"Differential Role of YAP During Wound Response and Tissue Expansion in Regeneration and Fibrosis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Leah Greenspan (National Institutes of Health, United States)
"Dissecting Vascular Reperfusion and Remodeling After Injury in Zebrafish"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Engineering Strategies for Regenerative Medicine
Discussion Leader: Elena Drudi (King's College London, United Kingdom)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
Anastasia PACARY (RESTORE institute-CNRS/UMR5070-INSERM/U1301, France)
"Digital Model of Tissue Repair Identifies an Early and Transient Decrease in Fiber Linking as Sufficient to Unlock Regeneration in Adult Mammals"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
Yasmin Roye (Duke University, United States)
"Targeting the Extracellular Matrix to Repair Hyperglycemia-Induced Glomerular Injury"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
Shoval Miyara (Weizmann Institute of Science, Israel)
"Circuit-to-Target Approach Defines an Autocrine Myofibroblast Loop That Drives Cardiac Fibrosis"
10:05 am - 10:10 am
Discussion
10:10 am - 10:25 am
Molly Klimak (Washington University in St. Louis, United States)
"Engineered Self-Regulating Macrophages for Targeted Anti-Inflammatory Drug Delivery"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Kyle Lam (St. Michael's Hospital, Canada)
"Mechanical Control of Exosome Formation by Mesenchymal Stromal Cells"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Building a Diverse and Inclusive Research Environment
Discussion Leader: Amanda Cimino (Washington University in St. Louis, United States)
1:30 pm - 1:35 pm
Introduction by Discussion Leader
1:35 pm - 2:30 pm
Panel Discussion
Strategies For Building a Diverse and Inclusive Research Environment
Joel Boerckel (University of Pennsylvania, United States)
Kimberly Mace (University of Manchester, United Kingdom)
Tanya Shaw (King's College London, United Kingdom)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
