Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Frontiers in Translation |
| Discussion Leader: Xiang-Lei Yang (The Scripps Research Institute, USA) |
7:40 pm - 8:10 pm | Keynote: Paul Schimmel (The Scripps Research Institute, USA) "The New Biology of Human tRNA Synthetases" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:30 pm | Selected from Poster Abstracts: Yan Qin (Institute of Biophysics, CAS, China) "A Mitochondrial Translation Quality Control Mechanism is Selectively Required for Male Fertility" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 8:45 pm | Selected from Poster Abstracts: Andrey Karamyshev (University of Texas Southwestern Medical Center, Dallas, USA) "Lost in Translation: Regulation of
Aberrant Protein Production (RAPP) in Health and Disease" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Keynote: Stephen Benkovic (Pennsylvania State University, USA) "Discovery and Development of Benzoxaboroles in Medicinal Chemistry" |
9:20 pm - 9:30 pm | Discussion |
Monday |
8:30 am | Group Photo |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Infectious Diseases and Immunity |
| Discussion Leader: Jonathan Yewdell (National Institutes of Health, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:35 am | Keynote: Ada Yonath (Weizmann Institute of Science, Israel) "Ribosomes for Medicine" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:05 am | Michael Ibba (The Ohio State University, USA) "Translation Quality Control Mediates Microbial Stress Responses" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Babak Javid (Tsinghua University School of Medicine, China) "Tuberculosis Antibiotic Tolerance Due to the Indirect Aminoacylation Pathway" |
10:35 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Robin Fahraeus (INSERM, France) "mRNA Translation Control Links Viral Immune Evasion with Cell Growth" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Jonathan Yewdell (National Institutes of Health, USA) "Translating Immunology" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Partho Sarothi Ray (IISER, Kolkata, India) "The
RNA-Binding Protein HuR Acts as a “microRNA Sponge” to Bind miR-21 and Prevent Translation Repression of Pro-Inflammatory Tumor Suppressor Gene Programmed
Cell Death 4" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Monika Wolkers (Sanquin Research, The Netherlands) "Post-Transcriptional Regulation Precludes Aberrant Cytokine Production in Memory T Cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Inflammatory Diseases |
| Discussion Leader: Melissa Ashlock (aTyr Pharma, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Kenneth Stuart (Seattle Biomedical Research Institute, USA) "Aminoacyl tRNA Synthetases for Two Cellular Translation Systems and Their Potential as Enhanced Drug Targets" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Min Guo (The Scripps Research Institute - Scripps Florida, USA) "Noncanonical Function of Lysyl-tRNA Synthetase Regulates the Allergic Response in Mast Cells" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Ingrid Lundberg (Karolinska Institutet, Sweden) "Anti-Jo-1 Antibodies- A Biomarker of a Distinct Subset of Inflammatory Myopathies" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Melissa Ashlock (aTyr Pharma, USA) "Seeing with New Eyes: Aminoacyl tRNA Synthetases as Modulators of Fundamental Pathways" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tumorigenesis |
| Discussion Leader: Sunghoon Kim (Seoul National University, South Korea) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Davide Ruggero (University of California, San Francisco, USA) "Translation Makes an Impact: Tailor-Made Protein Expression for Metabolism, Cancer and Disease" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:55 am | Robert Schneider (New York University School of Medicine, USA) "Translating the Regulation of Protein Synthesis to the Clinic in Metastatic Breast Cancer" |
9:55 am - 10:05 am | Discussion |
10:05 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Kun-Liang Guan (University of California, San Diego, USA) "mORC1 Regulation by Amino Acids" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Jamie Cate (University of California, Berkeley, USA) "Human eIF3 Targets Cell Proliferation mRNAs for Translational Activation or Repression" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Sunghoon Kim (Seoul National University, South Korea) "Aminoacyl-tRNA Synthetases as Dual Target for Cancer Metabolism and Signal Pathway" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Daniela Brina (National Institute of Molecular Genetics, Italy) "Translational Control Orchestrates Transcription
to Promote Metabolic Reprogramming" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Yohei Kirino (Thomas Jefferson University, USA) "Sex Hormone-Dependent tRNA Halves Enhance Cell Proliferation in Breast and Prostate Cancers" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Translation Modulation and Metabolic Diseases |
| Discussion Leader: Lluis Ribas de Pouplana (IRB Barcelona, Spain) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Lluis Ribas de Pouplana (IRB Barcelona, Spain) "A Mitochondrial Protein That Modulates Transcription, Translation, and Cell Cycle" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Anders Bystrom (University of Umea, Sweden) "Transfer RNA Modification Defects and Familial Dysautonomia (FD) Disease" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Rita Horvath (Institute of Genetic Medicine, United Kingdom) "Deficient RNA Metabolism as a Novel Target in Neuromuscular Disease" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Akshay Vaishnaw (Alnylam Pharmaceuticals, USA) "RNAi-Based Approaches for the Treatment of TTR Amyloidosis" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Neurological Disorders |
| Discussion Leader: Susan Ackerman (Howard Hughes Medical Institute / The Jackson Laboratory, USA) |
9:00 am - 9:30 am | Keynote: Nahum Sonenberg (McGill University, Canada) "Translational Control of Neurodevelopmental Disease" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:45 am | Introduction by Discussion Leader |
9:45 am - 10:05 am | Albena Jordanova (University of Antwerp, Belgium) "Unraveling the Role of Aminoacyl-tRNA Synthetases in Neurodegeneration: Come Fly With Us" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:35 am | Susan Ackerman (Howard Hughes Medical Institute / The Jackson Laboratory, USA) "Ribosome Pausing and Neurodegeneration" |
10:35 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Eric Klann (New York University, USA) "Dysregulated Translational Control in CNS Disorders" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Jennifer Darnell (Rockefeller University, USA) "Translational Control by Fragile X Mental Retardation Protein: Neuronal Targets and Mechanism" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Claudio Joazeiro (The Scripps Research Institute, USA) "The
E3 Ligase Listerin/Ltn1 Links Ribosome-Associated Protein Quality Control and
Neurodegeneration" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Truus Abbink (Vrije University Medical Centre / CNCR, The Netherlands) "Towards
the Molecular Disease Mechanism of Vanishing White Matter" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Vascular and Hematologic Disorders |
| Discussion Leader: Paul Fox (Cleveland Clinic, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Taisuke Kanaji (The Scripps Research Institute, USA) "Megakaryocyte Development and Platelet Production: Novel Role of Tyrosyl-tRNA Synthetase" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Alyson MacInnes (The Netherlands) "When Ribosomal Proteins Go Wrong" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Steven Ellis (University of Louisville, USA) "Diamond Blackfan Anemia: Genotype/Phenotype Relationships" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Paul Fox (Cleveland Clinic, USA) "Translational Readthrough of VEGFA mRNA Generates Anti-Angiogenic VEGF-Ax" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Stress-Induced Adaptive Translation / Translation Machinery as Therapeutic Targets |
| Discussion Leaders: Paul Anderson (Harvard Medical School, USA) and Susan Martinis (University of Illinois, Urbana-Champaign, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:25 am | Paul Anderson (Harvard Medical School, USA) "Angiogenin, tRNA, and Amyotrophic Lateral Sclerosis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Tao Pan (The University of Chicago, USA) "Methionine Mistranslation and Stress Response" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Myriam Gorospe (National Institute on Aging, USA) "Translational Control in Cellular Senescence" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:55 am | Coffee Break |
10:55 am - 11:15 am | Randal Kaufman (Sanford-Burnham Medical Research Institute, USA) "Is Protein Misfolding in the Endoplasmic Reticulum Oncogenic?" |
11:15 am - 11:25 am | Discussion |
11:25 am - 11:30 am | Introduction by Discussion Leader |
11:30 am - 11:40 am | Selected from Poster Abstracts: Auinash Kalsotra (University of Illinois, USA) "Poly(A) Binding Protein C1 Is Developmentally Regulated and Controls a Post-Transcriptional Pathway to Stimulate Cardiac Hypertrophy" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: Gerald McInerney (Karolinska Institutet, Sweden) "Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Karin Musier-Forsyth (The Ohio State University, USA) "Exploiting the Critical Role of tRNAs and Aminoacyl-tRNA Synthetases in Retroviral Replication for the Development of Novel HIV-1 Therapeutics" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Translation Machinery as Therapeutic Targets |
| Discussion Leader: Susan Martinis (University of Illinois, Urbana-Champaign, USA) |
7:30 pm - 7:40 pm | Selected from Poster Abstracts: Hanchao Zhao (University of Illinois at Urbana Champaign, USA) "Trafficking of Leucyl-tRNA Synthetase in E. coli" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:05 pm | Allan Jacobson (University of Massachusetts Medical School, USA) "Ataluren-Mediated Therapeutic Nonsense Suppression" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Selected from Poster Abstracts: Gwendolyn Gunn (University of Alabama at Birmingham, USA) "Evaluation of Nonsense Suppression and NMD inhibition in Response to Investigational 'Read-Through' Compounds" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Selected from Poster Abstracts: Norbert Polacek (University of Bern, Switzerland) "The Ribosome as Novel Target for Stress-Induced Small Regulatory RNAs" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Keynote: Jonathan Weissman (Howard Hughes Medical Institute / University of California, San Francisco, USA) "Monitoring Translation in Space and Time Through Ribosome Profiling" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |