Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Opening the New World of Translation
Discussion Leader: Sunghoon Kim (Seoul National University, South Korea)
7:40 pm - 8:25 pm
Nahum Sonenberg (McGill University, Canada)
"Translational Control of Cancer and
Neurodevelopmental Disease via eIF4E"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
C. Thomas Caskey (Baylor College of Medicine, USA)
"Genetic Risk Identification for Disease Prevention"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Post-Transcriptional Regulation in Cancer
Discussion Leader: Robert Schneider (New York University School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Katherine Borden (University of Montreal, Canada)
"Targeting the Multiple Lives of eIF4E in Leukemia"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
Raul Mendez (Institute for Research in Biomedicine (IRB Barcelona), Spain)
"The CPEB-Family of RNA-Binding Proteins, New Functions in Cell Cycle and Cancer"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Selected from Poster Abstracts: Maria Hatzoglou (Case Western Reserve University, USA)
"Unique Program of Adaptive ER Proteostasis During Chronic ER Stress"
10:05 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Davide Ruggero (University of California, San Francisco, USA)
"Translating the Cancer Genome One Codon at a Time and Its Therapeutic Implications"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
Estela Jacinto (Robert Wood Johnson Medical School, Rutgers University, USA)
"mTORC2 in Cell Metabolism"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
Jung Min Han (Yonsei University, South Korea)
"Leucyl-tRNA Synthetase as a Novel Target Against Rapamycin-Resistant Cancers"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
Maria Barna (Stanford University, USA)
"Ribosome Heterogeneity in Translating the Genetic Code"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Ania Wilczynska (MRC Toxicology Unit, United Kingdom)
"Recruitment of eIF4A2 and DDX6 by the Ccr4-NOT Complex Enforces Distinct Modes of Translational Repression"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolic Diseases
Discussion Leader: Andrew Weyrich (University of Utah School of Medicine, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
John Blenis (Weill Cornell Medicine, USA)
"mTOR, Metabolism and Therapeutic Opportunities"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Vadim Gladyshev (Brigham and Women's Hospital, Harvard Medical School, USA)
"Translation in Aging and Selenium Metabolism"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Scot Kimball (Penn State College of Medicine, USA)
"Modulation of Protein Synthesis as a Mechanism for Regulating Skeletal Muscle Growth and Atrophy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Paul Fox (Cleveland Clinic, USA)
"Glu-Pro tRNA Synthetase in mTOR Signaling and
Adiposity"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infectious and Inflammatory Diseases
Discussion Leader: Michael Ibba (The Ohio State University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Nancy Woychik (Rutgers University, USA)
"tRNAs, Translation and Tuberculosis"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Mirim Jin (Gachon University, South Korea)
"Secretion of a Protein Synthesis Enzyme as a Primary Defense Mechanism Against Pathogenic Challenges"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Marat Yusupov (Institute of Genetics and Molecular and Cellular Biology (IGBMC), France)
"Structural Basis for the Inhibition of the Eukaryotic Ribosome"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Alexander Mankin (University of Illinois at Chicago, USA)
"An Antibiotic that Inhibits Termination of Translation by Trapping Release Factors on the Ribosome"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Karin Musier-Forsyth (The Ohio State University, USA)
"Role of Aminoacyl-tRNA Synthetases in Retroviral Replication"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Andrew Mouland (Lady Davis Institute / McGill University, Canada)
"Identifying the Locales for Retroviral mRNA Translation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Rafael Kroon Campos (Duke University / University of Texas Medical Branch, USA)
"Identification of Ribosomal Stalk Proteins that Are Essential for Translation of Flavivirus Genomes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Control of Cancer Cells
Discussion Leader: Davide Ruggero (University of California, San Francisco, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Jerry Pelletier (McGill University, Canada)
"Targeting eIF4F-Dependencies in Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Robert Schneider (New York University School of Medicine, USA)
"Translational Control of the Breast Cancer Initiating Cell"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Stephane Pyronnet (Cancer Research Center of Toulouse, France)
"Translational Control of Pancreatic Function and Carcinogenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Ivan Topisirovic (Lady Davis Institute, McGill University, Canada)
"Translational Control of Cancer Energetics"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Kevin Webster (eFFECTOR Therapeutics, USA)
"Selective Therapeutic Intervention in mRNA Translation as a Novel Strategy to Treat Cancer"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurological Disorders
Discussion Leader: Tao Pan (University of Chicago, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Susan Ackerman (University of California, San Diego, USA)
"Translational Defects and Neurodegeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Samie Jeffrey (Weill Cornell Medicine, USA)
"Control of Neuronal mRNA Translation by m6A and m6Am"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Peter Todd (University of Michigan, USA)
"RAN Translation in C9orf72 Repeat Expansion Associated Neurodegeneration"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Joel Richter (University of Massachusetts Medical School, USA)
"Translational Control of the Fragile X Syndrome"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Robert Burgess (The Jackson Laboratory, USA)
"Mutations in Mouse Glycyl tRNA Synthetase: Profiling Transcription and Translation and Preclinical Studies"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Xiang-Lei Yang (The Scripps Research Institute, USA)
"Aminoacyl-tRNA Synthetase in
Charcot-Marie-Tooth Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Jennifer Darnell (The Rockefeller University, USA)
"Translational Repression by FMRP: Association with Neuronal Type-Specific mRNA Targets and Specific Binding to Stalled Ribosomes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Hong Joo Kim (St. Jude Children's Research Hospital, USA)
"Disturbance of RNA Granule Dynamics in Neurological Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Translational Responses to Stress
Discussion Leader: Xiang-Lei Yang (The Scripps Research Institute, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Nilabh Shastri (University of California, Berkeley, USA)
"Translational Control in Immune Surveillance"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Tao Pan (University of Chicago, USA)
"Dynamic
tRNA Biology in the Microbiome"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Shu-Bing Qian (Cornell University, USA)
"Translational Control in Heat Shock Response"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Michael Ibba (The Ohio State University, USA)
"Translation Quality Control and Stress Response in Bacteria"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovative Technologies for Translation Research
Discussion Leader: Robert Singer (Albert Einstein College of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Hiroaki Suga (University of Tokyo, Japan)
"A RaPID Way to Discover Pseudo-Natural Peptides Against Non-Druggable Targets"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Wenshe Liu (Texas A&M University, USA)
"Study Posttranslational Nucleosomal Modifications with an Expanded Genetic Code"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Iris Alroy (Anima Biotech Ltd., Israel)
"Screening for Protein Synthesis Modulators Using Fluorescent-Labeled tRNAs"
10:15 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Bin Wu (Johns Hopkins University School of Medicine, USA)
"Watching mRNA Translate"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Jean-Denis Beaudoin (Yale University, USA)
"Ribosomes Sculpt mRNA Structure During Embryogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Markus Schosserer (University of Natural Resources and Life Sciences, Vienna, Austria)
"Characterization of Ribosomal RNA Base Methylations Modulating Life and Healthspan"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Nicholas Ingolia (University of California, Berkeley, USA)
"Global Profiling of Translation Regulation and Dysregulation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Kyle Cottrell (Washington University School of Medicine, USA)
"Probing miRNA and RBP Function with CRE-seq"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular and Hematologic Disorders
Discussion Leader: Paul Fox (Cleveland Clinic, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Andrew Weyrich (University of Utah School of Medicine, USA)
"Translational
Functions of Anucleate Platelets in Health and Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Myung Hee Kim (Korea Research Institute of Bioscience and Biotechnology (KRIBB), South Korea)
"Control of Translational Initiation by a Human tRNA
Synthetase"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Jie Jia (Cleveland Clinic, USA)
"Co-Translational Complex Assembly in Macrophages"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
Selected from Poster Abstracts: Naoya Kenmochi (University of Miyazaki, Japan)
"Decreased Translational Efficiency of mRNAs Required for Hematopoiesis in a Zebrafish Model of Diamond-Blackfan Anemia"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure