Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Insights in Protein Synthesis Machinery
Discussion Leader: Tao Pan (University of Chicago, USA)
7:40 pm - 8:25 pm
Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, USA)
"Translation Elongation Regulation: Roadblocks and Resolutions"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Emily Spaulding (The Jackson Laboratory, USA)
"In Vivo Translational Profiling of Motor Neurons Reveals a Role for GCN2 Kinase in tRNA-Synthetase-Mediated Peripheral Neuropathy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Sergey Melnikov (Yale University, USA)
"Most Intracellular Parasites Produce Myriades of Protein Isoforms from Each Gene"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cancer
Discussion Leader: Laura Ranum (University of Florida College of Medicine, USA)
9:00 am - 9:20 am
Katherine Borden (University of Montreal, Canada)
"Dissecting eIF4E Activities and Its Biological Effects"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Poul Sorensen (University of British Columbia, Canada)
"Translational Regulation of Stress Responses and Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Sohail Tavazoie (The Rockefeller University, USA)
"Non-Canonical Roles for tRNA in Gene Regulation and Cancer"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Reuven Agami (Netherlands Cancer Institute, The Netherlands)
"Diricore, for the Detection of Amino Acid Vulnerabilities in Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Robert Schneider (New York University School of Medicine, USA)
"Translation Regulation of Breast Cancer Metastasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Andrew Hsieh (Fred Hutchinson Cancer Research Center, USA)
"The Androgen Receptor Regulates a Druggable Translational Regulon in Advanced Prostate Cancer"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Ataman Sendoel (The Rockefeller University, USA / University of Zurich, Switzerland)
"Translation from Unconventional 5' Start Sites Drives Tumour Initiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Susan Ackerman (University of California, San Diego / Howard Hughes Medical Institute, USA) and Xiang-Lei Yang (The Scripps Research Institute, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metabolic Diseases
Discussion Leader: Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:50 pm
Jody Puglisi (Stanford University, USA)
"Dynamics of Translation Initiation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sujatha Jagannathan (University of Colorado Anschutz Medical Campus, USA)
"Premature Stop Codon Context Regulates the Fate of Truncated Protein Products"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Eric Wang (University of Florida, USA)
"Regulation of RNA Localization and Local Translation by Muscleblind-Like Proteins"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christopher Nicchitta (Duke University Medical Center, USA)
"The Subcellular Organization of Translation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neurological Diseases
Discussion Leader: Gene Yeo (University of California, San Diego, USA)
9:00 am - 9:20 am
Laura Ranum (University of Florida College of Medicine, USA)
"Targeting RAN Translation and RAN Proteins Mitigates Disease in C9orf72 BAC ALS/FTD"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kate Meyer (Duke University, USA)
"Detecting m6A and Its Impact on Translation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Shuying Sun (Johns Hopkins University, USA)
"Understanding Repeat-Associated Non-AUG (RAN) Translation in C9orf72-ALS/FTD"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Gary Bassell (Emory University School of Medicine, USA)
"Modeling Fragile X Syndrome with Human iPSC Derived Neural Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Eric Klann (New York University, USA)
"Cell Type-Specific Translation in Emotional Memory"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Mridu Kapur (University of California, San Diego, USA)
"Expression of an Arginine tRNA Modulates Neuronal Excitability"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Elif Sarinay Cenik (University of Texas at Austin, USA)
"Maternal Ribosomes Are Sufficient for Tissue Diversification During Embryonic Development in C. elegans "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translational Responses to Stress
Discussion Leader: Zoya Ignatova (University of Hamburg, Germany)
7:30 pm - 7:50 pm
Gene Yeo (University of California, San Diego, USA)
"Comprehensive Discovery of RNA Binding Proteins that Influence RNA Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Paul Anderson (Brigham and Women's Hospital, USA)
"Angiogenin, tRNA and Amyotrophic Lateral Sclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Eric Bennett (University of California, San Diego, USA)
"Sensing Stress During Translation Through Regulatory Ribosomal Ubiquitylation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Sunghoon Kim (Seoul National University, South Korea)
"Novel Translation Initiation Complex Mediated by a tRNA Synthetase"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Translation in the Microbiome and in Pathogens
Discussion Leader: Paul Anderson (Brigham and Women's Hospital, USA)
9:00 am - 9:20 am
Zoya Ignatova (University of Hamburg, Germany)
"Regulation of RNA Modifications in Stress and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
A. Murat Eren (University of Chicago, USA)
"Microbiome Characterization Using Transfer RNA Sequencing"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Sophie Helaine (Imperial College London, United Kingdom)
"Targeting Translation for Persistence"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Babak Javid (Tsinghua University School of Medicine, China)
"Mycobacteria Use Alternate Ribosomes for Translation Under Nutrient Stress"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Scott Blanchard (Weill Cornell Medicine, USA)
"Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ya-Ming Hou (Thomas Jefferson University, USA)
"tRNA Methylation-A Determinant of Mitochondrial Pathogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Andrew Mouland (Lady Davis Institute / McGill University, Canada)
"Staufen1 and Optimal Translation and Trafficking of the HIV-1 Genomic RNA"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Clara Vincent (Uppsala University, Sweden / Weill Cornell Medicine, USA)
"Ribosome Biogenesis During Cell Cycle Arrest Fuels EMT in Development and Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Translation Diseases in the Immune and Hematological Systems
Discussion Leader: Katherine Borden (University of Montreal, Canada)
7:30 pm - 7:50 pm
Alexandre David (Institute of Functional Genomics (IGF), CNRS / INSERM, France)
"RNA Epigenetics Steers Cancer Cell Fate"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jonathan Yewdell (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Cancer Cells Seem to Know a Lot More About Ribosomes and T Cell Immunosurveillance than We Do"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Vijay Sankaran (Boston Children's Hospital / Harvard Medical School, USA)
"Translational Regulation in Human Hematopoiesis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Robin Fahraeus (Umea University, Sweden)
"Antigenic Peptides for the MHC Class I Pathway Are Derived from Pre-Spliced mRNAs"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Michael Polymenis (Texas A&M University, USA)
"Altered Translational Control in Ribosomal Protein Mutants"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovative Technologies for Translation Research
Discussion Leader: Jonathan Yewdell (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:20 am
Nicholas Ingolia (University of California, Berkeley, USA)
"DNA Double-Strand Breaks Trigger Ribosome Remodeling and Translational Shutdown"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ramanujan Hegde (MRC Laboratory of Molecular Biology, United Kingdom)
"Mechanistic Basis of Detection and Initiation of Ribosome Stalling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Selected from Poster Abstracts: Can Cenik (University of Texas at Austin, USA)
"On-Chip Method for Ribosome Profiling from Small Input Samples"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Selected from Poster Abstracts: Jian Lu (Peking University, China)
"Adaptive Evolution and Function of uORFs in Drosophila "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Alan Saghatelian (Salk Institute for Biological Studies, USA)
"Exploring the smORFeome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jonathan Weissman (University of California, San Francisco, USA)
"Systematic Analysis of Translational Quality Control from 20,000 Genes to 3 Angstroms"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Sichen Shao (Harvard Medical School, USA)
"Mechanism for Recycling tRNAs on Stalled Ribosomes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Carson Thoreen (Yale University, USA)
"LARP1 Links the Translation and Stability of TOP mRNAs Throughout the Transcriptome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondrial Translation
Discussion Leader: Nicholas Ingolia (University of California, Berkeley, USA)
7:30 pm - 7:50 pm
Zofia Chrzanowska-Lightowlers (Wellcome Centre for Mitochondrial Research, Newcastle University, United Kingdom)
"Unravelling the Intricacies of Human Mitochondrial Translation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Juan Alfonzo (The Ohio State University, USA)
"Dynamic Interplay Between tRNA Transport, Processing and Modification in T. brucei "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tsutomu Suzuki (University of Tokyo, Japan)
"Dynamic Regulation of tRNA Modification in Health and Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Brendan Battersby (University of Helsinki, Finland)
"Activation of a Mitochondrial Ribosome and mRNA Decay Pathway in Human Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure