Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Beyond the Canonical View of Protein Translation
Discussion Leaders: Zoya Ignatova (University of Hamburg, Germany) and Maria Hatzoglou (Case Western Reserve University, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
Susan Ackerman (University of California, San Diego / Howard Hughes Medical Institute, United States)
"mRNA Translation and Neurological Dysfunction"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Alexandre Germanos (Fred Hutch Cancer Center, United States)
"Single-Cell Sequencing Reveals Cellular Effects of Translational Stress in Hormone-Independent Prostate Cancer"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Yujing Cheng (UT SOUTHWESTERN MEDICAL CENTER, United States)
"A Non-Canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Oncogene-Induced Senescence"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Pathogens and Immunity
Discussion Leader: Christine Dunham (Emory University, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Christine Dunham (Emory University, United States)
"Inhibition of Novel Translational Control Mechanisms as an Antimicrobial Strategy"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Noam Stern-Ginossar (The Weizmann Institute of Science, Israel)
"Translation - a Tug of War During Viral Infection"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Philippe Pierre (INSERM, France)
"Translation Regulation and Innate Immunity: Friends or Foes?"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Alexander Mankin (University of Illinois at Chicago, United States)
"Reanimating the Large Ribosomal Subunit After Splitting of the Translating Ribosome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jonathan Yewdell (National Institute of Allergy and Infectious Diseases, NIH, United States)
"Channeled DRiP Translation and Degradation for T Cell Immunosurveillance"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Xiang-Lei Yang (The Scripps Research Institute, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Translation in and at Organelles
Discussion Leader: Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Brendan Battersby (University of Helsinki, Finland)
"The Infidelity of Human Mitochondrial Gene Expression"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Zhe Ji (Northwestern University, United States)
"Rfood-Seq: Transcriptomic R Nase Footprinting for Rapid Ribosome Profiling"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Robert Keenan (University of Chicago, United States)
"Translating Multipass Membrane Proteins at the ER"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Junjie Guo (Yale University, United States)
"Alternative Translation Initiation Generates Distinctly Functional Proteoforms"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Melissa Leger-Abraham (Harvard Medical School, United States)
"Specialized Translation Initiation Mechanisms in Parasites"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Gabriele Fuchs (The RNA Institute, University at Albany, United States)
"SARS-CoV2 RNA Translation Can Occur Cap-independently"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Innovative Technologies for Translation Research
Discussion Leader: Chuan He (University of Chicago, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Arvind Subramaniam (Fred Hutchinson Cancer Center, United States)
"Genetic Determinants of mRNA Stability in Human Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Daniel Zenklusen (Université de Montréal, Canada)
"A Single Molecule View of Cytoplasmic mRNPs"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Scott Blanchard (St. Jude Children's Research Hospital, United States)
"Structural and Mechanistic Insights into mRNA Decoding in Human"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rachel Green (Howard Hughes Medical Institute / Johns Hopkins School of Medicine, United States)
"Coordinated Responses by ZAK and GCN2 Kinases on Colliding Ribosomes Dictate Cell Fate"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
John Christodoulou (University College London, United Kingdom)
"Pathways to Protein Folding on the Ribosome"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Xiao Wang (MIT/Broad Institute, United States)
"Spatially Resolved Single-cell Translatomics"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sarah Loerch (University of California, Santa Cruz, United States)
"Where’s Waldo? Uncovering the Location of Idle Ribosomes in Neuronal Processes With 2D Template Matching"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress and Aging
Discussion Leader: Robert Schneider (New York University School of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Maria Hatzoglou (Case Western Reserve University, United States)
"The Many Pathways of Adaptation to the Environmental Stress of Hypertonicity"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Motomasa Tanaka (RIKEN Center for Brain Science, Japan)
"Dysregulated Translation Rhythms of Synaptic Genes in Neuropsychiatric Disorders"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Vadim Gladyshev (Brigham and Women's Hospital / Harvard Medical School, United States)
"Protein Synthesis in Aging and Longevity"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Shu-Bing Qian (Cornell University, United States)
"Codon-specific Ribosomal Pausing in Antiviral Stress Response"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer
Discussion Leader: Katherine Borden (University of Montreal, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Davide Ruggero (UCSF, United States)
"Decoding the Translatome in Diet, Metabolism, and Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Shobha Vasudevan (MGH-Harvard Medical School, United States)
"Post-transcriptional Mechanisms of Survival in Quiescent Cancer Cells"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Robert Schneider (New York University School of Medicine, United States)
"Translational Regulation of Regulatory T Cell Development, Function and Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Anne Willis (University of Cambridge, United Kingdom)
"Eukaryotic Initiation Factor 4B: A Multifunctional RNA Binding Protein"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Chuan He (University of Chicago, United States)
"mRNA Translation Regulation Through m6A and YTHDF1"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Yiwen Chen (University of Texas MD Anderson Cancer Center, United States)
"CRISPR-Cas9-based Functional Interrogation of Translatome Reveals Human Cancer Dependency on Hidden Open Reading Frames"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Murali Palangat (National Cancer Institute, NIH, United States)
"The Splicing Factor U2AF Binds mRNA in the Cytoplasm to Regulate Translation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ribosomopathies and Rare Diseases
Discussion Leader: Alexander Mankin (University of Illinois at Chicago, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Alan Warren (University of Cambridge, United Kingdom)
"Convergent Somatic Evolution from Early Life in a Germline Ribosomopathy"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Susan Baserga (Yale University, United States)
"When Good Ribosomes Go Bad"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Dragony Fu (University of Rochester, United States)
"Deciphering the Functions of tRNA Modification in Translation and Development"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Kathryn Oliver (Emory University School of Medicine, United States)
"Mechanistic Impact and Therapeutic Potential of Tuning Translation Efficiency to Rescue Disease-causing Variants in the Cystic Fibrosis Gene"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Maria Barna (Stanford University, United States)
"Rapid Remodeling of the Translatome Underlies Wound Healing and Tissue Regeneration"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Neurological Diseases
Discussion Leader: Susan Ackerman (University of California, San Diego / Howard Hughes Medical Institute, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Eric Klann (New York University, United States)
"Translational Control in Memory and Brain Disorders"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Xiang-Lei Yang (The Scripps Research Institute, United States)
"Link Translation to NAD+ Metabolism and Diabetes Through Seryl-tRNA Synthetase"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
Daryl Bosco (University of Massachusetts, United States)
"Stress-induced Translational Changes in Models of Neurodegenerative Disease"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Erik Storkebaum (Donders Institute and Radboud University, The Netherlands)
"Mismatch Between tRNA Supply and Codon Demand as a Pathogenic Mechanism Underlying Peripheral Neuropathy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Ana Soares (Institute of Biomedicine - University of Aveiro, Portugal)
"tRNA Modification Levels in Alzheimer’s Disease Correlate With Protein Aggregation Burden"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Haissi Cui (University of Toronto, Canada)
"Arg-tRNA Synthetase Links Inflammatory Metabolism to RNA Splicing and Nuclear Trafficking via SRRM2"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Or Shahar (MIGAL Galilee Research Institute, Israel)
"Cell-type-specific Detection of Newly Synthesized Proteins in Neurons in Vivo Reveals Activity-Dependent Translation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Robert Burgess (The Jackson Laboratory, United States)
"Preclinical Studies Testing Novel Therapeutic Approaches in Mouse Models of CMT2D"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Condensates and Complexes
Discussion Leader: Xiang-Lei Yang (The Scripps Research Institute, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Stephen Floor (University of California, San Francisco, United States)
"RNA Helicases in Health and Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Sunghoon Kim (Yonsei University, South Korea)
"Multi-tRNA Synthetase Complex in Health and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Kristin Koutmou (University of Michigan, United States)
"Modulation of the tRNA Modification Landscape Alters the Efficacy of Hygromycin B Translation Inhibition"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Karla Helena-Bueno (Newcastle University, United Kingdom)
"Life on Ice: The Atomic Structure of Psychrophilic Ribosomes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Sihao Huang (University of Chicago, United States)
"Applying Nanopore Sequencing of Transcriptome Pseudouridine Modification to Study Translation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure