Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Novel Molecular Insights into Protein Synthesis and Translation Factors
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"tRNA Modification Coordination and as Drivers of Translation Quality Control"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Protein Synthesis in Neurons"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Insights into Dysregulated Translation in Cancer
9:00 am - 9:20 am
"Drivers of Amino Acid Substitutants in Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"eIF5A-Dependent Feedback Inhibition from mRNA Translation Elongation to Initiation Induces Apoptosis in Tumor Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"N4-Acetylcytidine and N1-Methylpseudouridine Yield Distinctive Outcomes on Synthetic mRNA Translation Rate and Fidelity"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Characterization of a White Matter Brain Disorder Model Caused by the Loss of Arginyl-tRNA Synthetase from the Multisynthetase Complex"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Probing Translation and Its Control in Aging and Stress
7:30 pm - 7:50 pm
"Translation Surveillance Systems Direct Metabolic Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Direct and Indirect Mechanisms of Eukaryotic Translational Control"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Dysregulated mRNA Translation Elicits Neuropsychiatric Disorders"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Translation in Neurons and Disruption in Disease
9:00 am - 9:20 am
"Extracellular Aminoacyl-tRNA Synthetases and Neuropilin 1 Interactions Regulate Vascular Permeability"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transfer RNA Expression and Modification of Neurological Disorders"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Role of ER and Lysosomes in Shaping Membrane Protein Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Translation, Cell Stress, and tRNA Synthetase-Associated Peripheral Neuropathies"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Derailed Ribosomes and Human Disease
7:30 pm - 7:50 pm
"Regulating Ribosome Entry into Active Translation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Concentration Matters: Defining Determinants of Ribosome Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"In Situ Visualization of the Mammalian Translation Machinery"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Quality Control of Translation Machinery"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Turning Pathogens into Cell Biology Tools"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Four Proteins from the Family of mtAP2s Transcription Factors Piece Together the Highly rRNA-Fragmented Mitoribosome in Toxoplasma Gondii "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Expanding World of tRNA Modifications in Health and Disease"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Coordinated Changes of tRNA Modifications for Cellular Protein Homeostasis"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"How Slow-Growing Bacteria Adapt to Abrupt Stress"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Localized Translation and Organelles
7:30 pm - 7:50 pm
"Unique Features of the Mitochondrial Translation System in Health and Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Translation Dynamics in mRNA Localization to the Endoplasmic Reticulum"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exploiting a Functional Domain from tRNA Synthetase as a Novel Immune Modulator for Cancer and Viral Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Control of Epithelial Tissue Organization by mRNA Targeting to the Dermal-Epidermal Junction"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Global Methods for Dissecting Translation
9:00 am - 9:20 am
"Single Cell Measurements of mRNA Translation in the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mining Noncanonical Peptides Using Ribosome Profiling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Translation Elongation as a Rate Limiting Step of Protein Production"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Snapshots of Translation
7:30 pm - 7:50 pm
"In-cell Structural Analysis of Translation Regulation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"RNA Regulation in Male Germ Cells and Male Infertility"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ribosomes in Gene Regulation: Controlling the Diversity of Proteins Made in Specific Cells, Tissues, and Organisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Spatiotemporal Understanding of Protein Synthesis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure