Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Understanding Mechanisms of Neurodegenerative Disease
3:45 pm - 4:20 pm
"Expanding Mechanisms and Therapeutic Targets for Neurodegenerative Disease"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ribosomes, Protein Translation and Disease
7:30 pm - 7:45 pm
"Cytoplasmic NAD+ Inhibits mRNA Translation by Regulating MonoADP-Ribosylation on Ribosomal Proteins"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Ribosomal Protein L12 (uL11) Depletion Partially Restores Functional Expression of Multiple CF-Causing Variants"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation During Cellular Stress"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"RPS25 Regulates RAN Translation of C9orf72 Repeat Expansions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Repression of Ferritin Light Chain Translation by Human eIF3"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"2'-O-Methylation of Cytosolic tRNAs by FTSJ1: Implications for the Molecular Pathogenesis of X-Linked Mental Retardation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
9:00 am - 9:15 am
"How Is Ribosome Stalling Relieved and Coupled to mRNA Decay?"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"In Vivo Translational Profiling of Motor Neurons Reveals a Role for GCN2 Kinase in tRNA-Synthetase-Mediated Peripheral Neuropathy"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Functional Characterization of Mycobacterial GatCAB from Clinically Relevant Mutants in Regulating Translational Fidelity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"eEF2 Knockdown in Mouse Liver Leads to mTOR-Independent Translational Upregulation of Ribosomal Genes"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Most Intracellular Parasites Produce Myriades of Protein Isoforms from Each Gene"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Characterization of the mTORC1 Effector PDCD4 in Activity Dependent Translation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Visibility
1:30 pm - 2:20 pm
"Visibility: Increase It Today"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes