Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Unraveling Ribosome Assembly
Discussion Leader: Travis Lantz (Stanford University, United States)
3:45 pm - 4:15 pm
Katrin Karbstein (UF Scripps Biomedical Research, United States)
"Quality Control in 40S Ribosome Assembly"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Controlling Translation
Discussion Leader: Jiaxin Li (Jackson Laboratory, United States)
7:30 pm - 7:40 pm
Gita Gajjar (East Carolina University, United States)
"Translation Initiation: Key to Understanding Protein Synthesis"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
José Liboy-Lugo (University of California, San Francisco, United States)
"G3BPs Regulate Translation of mRNAs During the Mammalian Integrated Stress Response"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Julia Jones (The Scripps Research Institute, United States)
"The Metabolic Regulation of Nuclear Tyrosyl-tRNA Synthetase"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Karla Helena-Bueno (Newcastle University, United Kingdom)
"Life on Ice: The Atomic Structure of Psychrophilic Ribosomes"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Sihao Huang (University of Chicago, United States)
"Applying Nanopore Sequencing of Transcriptome Pseudouridine Modification to Study Translation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Anand Singh (ST JUDE CHILDRENS RESEARCH HOS, United States)
"Real-time Optogenetics Manipulation to Dissect Transcriptional Kinetics and Regulation"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Alexandre Germanos (Fred Hutch Cancer Center, United States)
"Single-cell Sequencing Reveals Cellular Effects of Translational Stress in Hormone-independent Prostate Cancer"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Molumby (University of California San Diego, United States)
"A tRNA Brain Atlas Reveals Cell Type-specific Gene Contribution Regulates Cellular Homeostasis"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
RNAs, Proteins, and Translation in Disease
Discussion Leader: Alana Gibson (University of California, San Diego, United States)
9:00 am - 9:10 am
Jianjie Dong (Scripps Research, United States)
"Adaptation of Pancreatic Beta Cells to Metabolic Stress Through tRNA Synthetases"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Timothy Hines (The Jackson Laboratory, United States)
"The Role of ATF4 on the Neuropathy Phenotype of Charcot-Marie-Tooth Disease Type 2D Mouse Models"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Merve Yigit (Institute for Regenerative Medicine, University of Zurich, Switzerland)
"Deciphering the Role of the Alternative Initiation Factor eIF2A in Cancer"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Qiuxia Zhao (University of Texas at Austin, United States)
"Hypodermal Ribosome Synthesis Inhibition Induces a Nutrition-uncoupled Organism-wide Growth Quiescence in C. Elegans"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Matthew Payea (National Institute on Aging, United States)
"Senescent Cells are Resistant to Integrated Stress Response Activation due to Translational Defects"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Yujing Cheng (UT SOUTHWESTERN MEDICAL CENTER, United States)
"A Non-canonical Role for a Small Nucleolar RNA in Ribosome Biogenesis and Oncogene-induced Senescence"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Kejia Zhang (University of Rochester, United States)
"Deciphering the Biological Functions of tRNA Methyltransferase 1 in Development and Disease"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Marcus Foo (University of Chicago, United States)
"Discovering and Characterizing Bacterial tRNA N1-methyladenosine Writer and Eraser in Streptomyces Venezuelae"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Translating Ideas Into Applications - Career Panel Discussion With Dr. Anastassiadis, Dr. Ullrich, and Dr. Karbstein
Discussion Leader: Wen Zhang (University of Chicago, United States)
1:30 pm - 2:30 pm
Panel Discussion
Careers in Industry and Careers in Publishing
Theonie Anastassiadis (Alltrna and Flagship Pioneering, United States)
Katrin Karbstein (UF Scripps Biomedical Research, United States)
Florian Ullrich (Nature, Germany)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes