Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Arboviruses and
Vector-Parasite Interactions
Discussion Leader: Jesus Valenzuela (National Institutes of Health, USA)
7:40 pm - 8:20 pm
Scott Weaver (University of Texas Medical Branch, USA)
"Emerging Urban Arboviruses Invading the Americas: Chikungunya, Zika and What Next?"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Serap Aksoy (Yale University School of Medicine, USA)
"Eliminating Sleeping
Sickness: Expanding the Vector Control Toolbox"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Research and Control for Worms and Neglected Bacteria
Discussion Leaders: Maria Elena Bottazzi (Baylor College of Medicine, USA) and Nelly El-Sakkary (University of California, San Diego, USA)
9:00 am - 9:15 am
Lynn Soong (The University of Texas Medical Branch , USA)
"Type 1-Skewed Neuroinflammation and Vascular Leakage Associated with Orientia tsutsugamushi Infection"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Monica Vieira (Instituto Butantan, Brazil)
"Heparin-Binding Protein Release Is Strongly Induced by Leptospira spp . and Is a Candidate as Early Diagnostic Marker of Human Leptospirosis"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Bo Wang (Stanford University, USA)
"Exploiting Schistosome-Host Cell Interactions Using Nano Scale Tools"
9:55 am - 10:00 am
Discussion
10:00 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Alex Loukas (James Cook University, Australia)
"Hookworms Ain't All Bad News: Treating Inflammatory Diseases with Hookworms and Their Secreted Proteins"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Meera G. Nair (University of California, Riverside, USA)
"Function of Monocytes and Macrophages in Immunity and Inflammation to Hookworms"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Conor Caffrey (University of California, San Diego, USA)
"Small-Molecule Drug Screening Approaches for Helminth Parasites"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Carolina Barillas-Mury (National Institutes of Health, USA) and Serap Aksoy (Yale University School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chagas Disease and Leishmaniasis, Pathogenesis and Immunity
Discussion Leaders: Eric Dumonteil (Tulane University, USA) and Laura-Isobel McCall (University of Oklahoma, USA)
7:30 pm - 7:45 pm
Santuza Teixeira (Federal University of Minas Gerais, Brazil)
"Surface Proteins as Virulence Factors in Trypanosoma cruzi and Leishmania : The Case for Trans-Sialidases and Amastins"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Nisha Garg (University of Texas Medical Branch, USA)
"Multiple Roles of Mitochondria in Chagas Disease"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Igor Almeida (University of Texas at El Paso, USA)
"Glycan-Based Vaccine for Chagas Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Walderez Dutra (Federal University of Minas Gerais, Brazil)
"Cellular and Molecular Mechanisms of Protective and Pathogenic Immune Response in Chagas Disease"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Nathan Peters (University of Calgary, Canada)
"Recruitment, Modulation, and Activation of Inflammatory Cells in the Skin Following Infection with Leishmania: Implications for Vaccination"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emergent Arboviruses: Zika, Dengue and Chikungunya
Discussion Leaders: Nikos Vasilakis (University of Texas Medical Branch, USA) and Berlin Londono-Renteria (Kansas State University, USA)
9:00 am - 9:20 am
Albert Ko (Yale School of Public Health, USA)
"Zika Virus Congenital Syndrome and Its Emergence in the Americas"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
George Dimopoulos (Johns Hopkins Bloomberg School of Public Health, USA)
"Zika Virus – Mosquito Interactions: Exploring Transmission Bottlenecks"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Sasha Azar (University of Texas Medical Branch, USA)
"Vector Competence Analysis of Aedes spp. Mosquitoes from the Americas for Zika Virus"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Sujatha Sunil (International Centre for Genetic Engineering and Biotechnology, India)
"Role of Aedes microRNAs in Chikungunya Virus Replication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Eva Harris (University of California, Berkeley, USA)
"New Findings in Zika Pathogenesis, Immunology, and Diagnostics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Shee-Mei Lok (Duke-NUS Medical School, Singapore)
"Structure of the Thermally Stable Zika Virus"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Stephen Whitehead (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Development of a Sustainable Live Attenuated Vaccine Candidate for Zika Virus"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microbiomes of Vectors and Leishmania
Discussion Leaders: Serap Aksoy (Yale University School of Medicine, USA) and Fabio Gomes (National Institute of Allergy and Infectious Disease, NIH, USA)
7:30 pm - 7:50 pm
Martin Olivier (McGill University, Canada)
"Impact of Sand Fly Nanobiome on Cutaneous Leishmaniasis Development"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Stephen Beverley (Washington University School of Medicine in St. Louis, USA)
"Leishmania RNA Viruses and Parasite Virulence"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mary Wilson (University of Iowa, USA)
"The Contribution of Insect Microbiota to Vector-Borne Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Shaden Kamhawi (National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Unlikely Suspect: A Vital Role for Midgut Microbiota in Virulence of Vector-Transmitted Leishmania Parasites"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Vector Biology Research
Discussion Leaders: Saravanan Thangamani (University of Texas Medical Branch, USA) and Iliano Coutinho-Abreu (National Institutes of Health, USA)
9:00 am - 9:20 am
Joao Pedra (University of Maryland School of Medicine, USA)
"Tick Inhibition of NLRC4 Inflammasome Activation During Microbial Transmission"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Alvaro Molina-Cruz (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Plasmodium Evasion of Mosquito Immunity and the Global Spread of Malaria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Pamela Pennington (Universidad del Valle de Guatemala, Guatemala)
"Paratransgenesis: The Unlikely Road from Lab to Field"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Brian Weiss (Yale School of Public Health, USA)
"Colonization of the Tsetse Fly Midgut with Commensal Enterobacter Inhibits Trypanosome Infection Establishment"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Tiago Serafim (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Beyond Metacyclogenesis: The Secret Behind the Remarkable Success of Leishmania Transmission by a Vector Bite"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Abdoulaye Diabate (Institute de Recherche en Sciences de la Sante (IRSS) / Centre Muraz, Burkina Faso)
"GM Fungi to Control Insecticide Resistant Mosquito Populations"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Anandasankar Ray (University of California, Riverside, USA)
"Mosquito Behavior Modifying Odors as Prophylactics for Malaria, Dengue and Zika"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Basic and Field Work Advances in Malaria
Discussion Leaders: Rick Fairhurst (National Institutes of Health, USA) and Joel Vega-Rodriguez (Johns Hopkins University, USA)
7:30 pm - 7:45 pm
Xin-Zhuan Su (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Immunogenomics of Malaria: Genome-Wide Host-Parasite Interactions and Novel Regulators in IFN-I Signaling"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Rongfu Wang (Houston Methodist Research Institute, USA)
"Cross-Regulation of Type I IFN Signaling Pathways in pDCs Dictates Anti-Malaria Immunity and Host Mortality"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Kirk Deitsch (Weill Cornell Medicine, USA)
"Mechanisms for Coordinating Expression of Multicopy Gene Family Members in Malaria Parasites"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Peter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Unraveling the Cellular and Molecular Basis of Immunity to Malaria"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Peter Billingsley (Sanaria Inc., USA)
"PfSPZ Vaccines to Prevent and Eliminate Malaria"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Translational Strategies to Prevent Tropical Diseases
Discussion Leader: Fabiano Oliveira (National Institutes of Health, USA)
9:00 am - 9:20 am
Afzal Siddiqui (Texas Tech University Health Sciences Center School of Medicine, USA)
"Sm-p80-Based Vaccine for Intestinal and Urinary Schistosomiasis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Steven Reed (Infectious Disease Research Institute, USA)
"Designer Adjuvants for Neglected Infectious Diseases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Hira Nakhasi (Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration, USA)
"Early Interaction Between DCs and the Live Attenuated Leishmania donovani Parasites Reveals Novel Biomarkers of Protective Immunity Against Visceral Leishmaniasis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Camila De Oliveira (Fundação Oswaldo Cruz, Brazil)
"Estimating Vector Exposure and Risk of CL Development Using Lutzomyia intermedia Linb13"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Alvaro Acosta-Serrano (Liverpool School of Tropical Medicine, United Kingdom)
"Targeting Tyrosine Metabolism as a Novel Approach for Tsetse Control"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Maria Elena Bottazzi (Baylor College of Medicine, USA)
"Global Access Strategies for NTD Vaccines: Translating Science into Sustainable Business Cases and Innovative Investment Mechanisms"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Luciano Moreira (Centro de Pesquisa Rene Rachou, Fiocruz Minas, Brazil)
"Using Wolbachia in an Integrative Approach to Control Arboviruses"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Host-Parasite Interactions and Innate Immunity
Discussion Leader: Carolina Barillas-Mury (National Institutes of Health, USA)
7:30 pm - 8:15 pm
Ricardo Gazzinelli (Centro de Pesquisa Rene Rachou, Fiocruz Minas, Brazil)
"Killing of Plasmodium vivax Infected Reticulocytes by Killer T Cells"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
Marcelo Jacobs-Lorena (Johns Hopkins Bloomberg School of Public Health, USA)
"What Peptides Taught Us About the Life Cycle
of the Malaria Parasite"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure