| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | OPENING SESSION / KEYNOTE ADDRESSES |
| Discussion Leader: James Sacchettini (Texas A&M University)
Opening Remarks |
| 7:30 pm - 8:15 pm | Keynote Address: Peter Small |
| 8:15 pm - 9:00 pm | Keynote Address: Barry Furr (AstraZeneca)
"Economics of Tuberculosis Drug Discovery" |
| 9:00 pm - 9:30 pm | Keynote Address: Christopher Lipinski (Pfizer Global R&D) |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | PERSISTENCE FACTORS AS DRUG TARGETS |
| Discussion Leader: Eric Rubin (Harvard) |
| 9:00 am - 9:45 am | Sabine Ehrt (Cornell University)
"Controlling mycobacterial gene expression in vitro and in vivo" |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 11:00 am | John Blanchard (Albert Einstein College of Medicine)
"Fluoroquinolones, resistance and tuberculosis" |
| 11:00 am - 11:45 am | Laura Via (NIH)
"Importance of TB's microenvironment in persistence and efficacy of drug treatment" |
| 11:45 am - 12:30 pm | Chris Sassetti (University of Massachusetts)
"Genetic analysis of mycobacterial adaptation to the host environment" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (set-up) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | TARGETING DORMANT BACTERIA |
| Discussion Leader: Douglas Young (Imperial College) |
| 7:30 pm - 8:15 pm | John McKinney (Rockefeller University)
"Hard target: Persistence mechanisms in Mycobacterium tuberculosis" |
| 8:15 pm - 9:00 pm | Kim Lewis (North Eastern University)
"Molecular mechanisms of bacterial dormancy" |
| 9:00 pm - 9:30 pm | David Sherman (University of Washington)
"DosRx -- targeting the TB hypoxic response" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DRUGS, TARGETS, AND RESISTANCE |
| Discussion Leader: Valerie Mizrahi (University of the Witwatersrand) |
| 9:00 am - 9:45 am | William Jacobs (Albert Einstein School of Medicine)
"Isoniazid mechanism of action: What we know and what we do not know" |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 11:00 am | Carolyn Bertozzi (University of California Berkley)
"Sulfation pathway's in Mtb. tuberculosis" |
| 11:00 am - 11:30 am | Digby Warner (University of the Witwatersrand)
"The mycobacterial response to DNA gyrase inhibitors: a role for error-prone DNA repair in induced mutagenesis?" |
| 11:30 am - 12:00 pm | Ujjini Manjunatha (NIAID, NIH)
"Mechanism of action of nitroimidazoles against M. tuberculosis" |
| 12:00 pm - 12:30 pm | Harvey Rubin (University of Pennsylvania)
"Biochemical characterization of NADH oxidoreductase from Mtb." |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HIGH-THROUGHPUT AND VIRTUAL SCREENING |
| Discussion Leader: Ken Duncan (UK) |
| 7:30 pm - 8:15 pm | Tanjore Balganesh (AstraZeneca)
"Lead generation approaches: details of an antimycobacterial discovery project" |
| 8:15 pm - 9:00 pm | Jose Garcia-Bustos (GlaxoSmithKline)
"The challenges of finding a drug-like inhibitor of isocitrate lyase" |
| 9:00 pm - 9:30 pm | Gerald Newton (University of California San Diego)
"Mycothiol biosynthesis as a drug target in Mycobacterium tuberculosis: Development and testing of a high-throughput screening assay for MshC ligase, an essential enzyme of mycothiol biosynthesis" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LEAD OPTIMIZATION AND ADME |
| Discussion Leader: Melvin Spigelman (TB Global Alliance) |
| 9:00 am - 9:45 am | Bala Subramanian (Astrazeneca)
"PK/PD approach to lead optimisation: Pitfalls and possibilities" |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 10:30 am | Clifton Barry (NIAID NIH)
"Structural determinants of aerobic and anaerobic activity in antituberculous nitroimidazoles" |
| 10:30 am - 11:00 am | Markus Wenk (National University of Singapore)
"Lipidomics of mycobacteria during hypoxic dormancy" |
| 11:00 am - 11:45 am | Thomas Dick (Novartis)
"Peptide deformylase inhibitors for TB" |
| 11:45 am - 12:30 pm | TBA |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (set-up) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | STRUCTURE-BASED APPROACHES |
| Discussion Leader: Kurt Krause (University of Houston) |
| 7:30 pm - 8:15 pm | Tom Alber (University of California Berkley)
"Structural basis of Ser/Thr protein kinase signaling in M. tuberculosis" |
| 8:15 pm - 8:40 pm | Edward Baker (University of Auckland)
"Structural biology of enzymes on the pathways to mycobactin biosynthesis: potential new drug candidates" |
| 8:40 pm - 9:05 pm | Annette Roos (Uppsala University)
"Structural and kinetic studies of Mycobacterium tuberculosis ribose-5-phosphate isomerase B" |
| 9:05 pm - 9:30 pm | Shekhar Mande (Centre for DNA Fingerprinting and Diagnostics)
"Structural studies on thioredoxin reductase" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ANIMAL MODELS |
| Discussion Leader: William Bishai (John Hopkins University) |
| 9:00 am - 9:45 am | Anne Lenaerts (Colorado State University)
"Animal model testing of tuberculosis drugs" |
| 9:45 am - 10:15 am | Coffee Break |
| 10:15 am - 11:00 am | Yukari Manabe (Johns Hopkins University)
"The rabbit model of latency, reactivation and paradoxical worsening" |
| 11:00 am - 11:30 am | Joanne Flynn (University of Pittsburgh)
"Using non-human primates in tuberculosis research" |
| 11:30 am - 12:00 pm | Ping Chen (Sequella)
"Synergistic killing of Mycobacterium tuberculosis by the combination of Rifampin (RIF) and SQ109, a new TB drug candidate" |
| 12:00 pm - 12:30 pm | Christine Johnson (Colorado State University)
"Oral therapy using nanoparticle encapsulated anti-tuberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CLINICAL TRIALS AND NEW THERAPEUTIC STRATEGIES |
| Discussion Leader: Denis Mitchison (St George's Hospital Medical School, London) |
| 7:30 pm - 8:15 pm | Koen Andries (Johnson & Johnson)
"Discovery of R207910, an ATP synthase inhibitor" |
| 8:15 pm - 9:00 pm | Felicity Perrin (Centre for Medical Microbiology)
"TB chemotherapy: Surrogate markers of treatment response" |
| 9:00 pm - 9:30 pm | Anne Goldfeld (Harvard Medical School)
"Immunotherapeutic approaches to treat TB" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
