SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Welcome Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | STRATEGIES FOR THE DEVELOPMENT AND DEPLOYMENT OF NEW ANTIBIOTICS |
| Discussion Leader: Valerie Mizrahi (University of the Witwatersrand) |
7:40 pm - 7:45 pm | Welcome, Opening Remarks, & Announcements by Chair: Valerie Mizrahi |
7:45 pm - 8:25 pm | Christopher T. Walsh (Harvard Medical School) "Antibiotics for TB: Present and Future" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Nulda Beyers (Stellenbosch University) "The impact of new drugs on the eradication of TB" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | LESSONS FROM THE BROAD-SPECTRUM AREA |
| Discussion Leader: Bala Subramanian (Astrazeneca, India) |
9:00 am - 9:45 am | Trevor Trust (Astrazeneca) "The experience of Helicobacter pylori" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 11:00 am | Steven Projan (Wyeth Research) "Antibacterial drug discovery in the 21st Century" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Richard Lee (University of Tennessee) "Revisiting old targets in new ways" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Michael Fischbach (Harvard Medical School) "Strategies for developing new TB antibiotics" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SCIENTIFIC ISSUES IN PRECLINICAL AND EARLY CLINICAL DEVELOPMENT |
| Discussion Leader: Clifton E. Barry III (NIAID, NIH) |
7:30 pm - 8:00 pm | David McNeeley (Tibotec) "Update on the clinical development of TMC207: a novel TB compound to treat drug-susceptible and drug-resistant tuberculosis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Gerry Davies (University of Liverpool) "Pharmacokinetics and pharmacodynamics in clinical development of new anti-tuberculosis drugs" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Anne Lenaerts (Colorado State University) "Challenges in preclinical testing of new TB drugs" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | NEW TARGET AREAS |
| Discussion Leader: Harvey Rubin (University of Pennsylvania) |
9:00 am - 9:45 am | Peter Tonge (Stony Brook University, NY) "Mycolic acid and menaquinone biosynthesis: Mining the Magic Mountain for novel TB drugs" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Cynthia Dowd (George Washington University) "The structural determinants of aerobic versus anaerobic antitubercular activities of nitroimidazoles" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Dean Crick (Colorado State University) "Targeting non-replicating Mycobacterium tuberculosis with menaquinone synthesis inhibitors" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Anil Koul (Johnson & Johnson, Belgium) "AtpE, an oligomeric and proteolipic subunit of ATP synthase, is the target for antimycobacterial activity of diarylquinolines" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Ramandeep Singh (NIAID, NIH) "Suicide and survival of Mycobacterium tuberculosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ENVIRONMENTAL RESPONSES AND DRUG TOLERANCE |
| Discussion Leader: David Sherman (Seattle Biomedical Research Institute) |
7:30 pm - 8:00 pm | Bruce Levin (Emory University) "The population dynamics of antibiotic treatment failure in the absence of
resistance" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Kevin Pethe (Novartis Institute for Tropical Diseases) "Persistence mechanisms and drug tolerance in dormant mycobacteria" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Neeraj Dhar (Rockefeller University) "Single cell observational studies of INH persisters in mycobacteria" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | TARGETING MACROMOLECULAR SYNTHESIS AND TURNOVER |
| Discussion Leader: Thomas Dick (Novartis Institute for Tropical Diseases) |
9:00 am - 9:45 am | Carl Nathan (Cornell University) "Targeting macromolecules at distinct phases of their life cycle: Synthesis,
repair and degradation" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Rajesh Gokhale (NII, India) "Multifunctional polyketide synthases for biosynthesis of complex mycobacterial lipids" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Helena Boshoff (NIAID) "Evaluating drug targets in peptidoglycan synthesis and remodeling" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Courtney Aldrich (University of Minnesota) "Antitubercular nucleosides that inhibit siderophore biosynthesis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s)) |
7:30 pm - 9:30 pm | REGULATION AND METABOLISM |
| Discussion leader: Tom Alber (UC Berkeley) |
7:30 pm - 8:00 pm | Jim Sacchettini (Texas A&M University) "New drug targets from metabolic pathways" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Vrinda Nandi (AstraZeneca, India) "Targeting acetolactate synthase for novel anti-tubercular agents" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Nicole Sampson (Stony Brook University) "Purification and characterization of a putative 3β-hydroxysteroid dehydrogenase from Mycobacterium tuberculosis" |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | NEW TECHNOLOGIES |
| Discussion Leader: Eric Rubin (Harvard) |
9:00 am - 9:25 am | John Overington (Inpharmatica, UK) "Large-scale prioritisation of drug targets using a knowledge-based approach" |
9:25 am - 09:35 am | Discussion |
9:35 am - 10:00 am | Chris Abell (University of Cambridge, UK) "Fragment based drug discovery - from crystal to clinic" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Lalita Ramakrishnan (University of Washington) "The zebrafish model to study mycobacterial replication dynamics and its relationship to antibiotic susceptibility" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Sarah Fortune (Harvard School of Public Health) "Separate but not equal: Genomic diversity in mycobacteria" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Tanya Parish (Barts and the London) "Conditional gene expression in M. tuberculosis for target validation" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GETTING DRUGS TO THEIR TARGETS |
| Discussion Leader: Ken Duncan (Bill & Melinda Gates Foundation) |
7:30 pm - 8:00 pm | Paul Tulkens (Université Catholique de Louvain, Belgium) "Cellular uptake and disposition of antibiotics: how can they reach and act on their targets?" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | George Drusano (Ordway Research Institute) "Suppression of drug resistance in Mycobacterium tuberculosis through dose and schedule choice" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Chris Lipinski (Melior Discovery) "Wrap-up and concluding comments" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |