SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:30 pm | Welcome Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | The Global Challenge of Tuberculosis |
| Discussion Leader: Bala Subramanian (AstraZeneca) |
7:40 pm - 8:20 pm | Gary Maartens (University of Cape Town) "A Tale of Two Epidemics: HIV and TB" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Zarir Udwadia (Hinduja Hospital) "Tackling MDR and XDR TB in resource limited settings: the Indian scenario" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Potential New Targets for Treating Tuberculosis |
| Discussion Leader: Valerie Mizrahi (University of the Witwatersrand) |
9:00 am - 9:35 am | Christopher Sassetti (University of Massachusetts Medical School) "Metabolic adaptations required for infection and dormancy" |
9:35 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Juliane Ollinger (IDRI) "Signal peptidase I as a target for the development of new treatments against Mycobacterium tuberculosis" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 11:00 am | Giovanna Riccardi (University of Pavia) "Rv3790 from Mycobacterium tuberculosis is the magic target" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Deborah Hung (Broad Institute) |
11:40 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Lisa Prach (University of California, Berkeley) "Structure and biosynthesis of novel diterpenes in Mycobacterium tuberculosis" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Marie Lavollay (University of Paris V) "L,D-Transpeptidases of Mycobacterium tuberculosis : Novel cell-wall targets for the eradication of non-replicative forms of Mycobacterium tuberculosis?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New chemical entities I |
| Discussion Leader: José Garcia-Bustos (GlaxoSmithKline) |
7:30 pm - 8:00 pm | Thomas Dick (Novartis Institute for Tropical Disease) "Hits from aerobic and anaerobic whole cell and respiratory vesicle screens" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Vadim Makarov (AN Bakh Institute of Biochemistry) "1,4-Benzothiazinones - new class of antituberculosis compounds" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Sunita DeSousa (AstraZeneca) "Twists and a tale - DNA gyrase for TB drug discovery" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Screening for new antibiotics |
| Discussion Leader: Stewart Cole (EFPL) |
9:00 am - 9:35 am | Priscille Brodin (Institut Pasteur Korea) "High content screening on the Mycobacterium tuberculosis infected macrophage" |
9:35 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Thulassi Warrier (Max Planck Institute, Berlin) "Identification and Characterization of Small Molecule Inhibitors of Mycobacterium tuberculosis Antigen 85C" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Derek Tan (Memorial Sloan Kettering) "Natural product-based libraries for chemical biology and drug discovery" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Robert Reynolds (Southern Research Institute) "High throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Randy Basaraba (Colorado State University) "The formation and survival of microbial communities of Mycobacterium tuberculosis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Model systems |
| Discussion Leader: Ken Duncan (Bill and Melinda Gates Foundation) |
7:30 pm - 8:00 pm | Tawanda Gumbo (University of Texas, Southwestern) "From bactericidal to sterilizing effect: Evidence that in vitro PK/PD model systems
correlate with clinical outcomes" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Ajit Lalvani (Imperial College) "Biomarkers of treatment response to accelerate clinical trials of new drugs" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | JoAnne Flynn (University of Pittsburgh) "Predicting drug cure at the single lesion level: the use of imaging in TB drug studies" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | New chemical entities II |
| Discussion Leader: Véronique Dartois (Novartis Institute for Tropical Disease) |
9:00 am - 9:35 am | David Barros (GlaxoSmithKline) "Novel Mtb DNA gyrase inhibitors" |
9:35 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Sylvia Luckner (Rudolph Virchow Center) "Mycobacterial Cell Wall Biosynthesis and Inhibition of KasA by Thiolactomycin" |
9:55 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Jean-Emmanuel Hugonnet (Albert Einstein College of Medicine) "Tuberculosis: Finding and Achilles heel" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Geoffrey Coxon (University of Strathclyde) "The identification of 2-aminothiazole-4-carboxylates active against Mycobacterium tuberculosis" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Eric Nuermberger (Johns Hopkins) "Pre-clnical results with PNU-100480 and further observations on testing new drugs in mice" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Alternative approaches to tuberculosis therapy |
| Discussion Leader: Jim Sacchettini (Texas A&M) |
7:30 pm - 8:10 pm | Jacques Neefjes (The Netherlands Cancer Institute) "Development of the host kinase and phosphatase inhibitors to control bacterial infections. And how they work" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Gilla Kaplan (Public Health Research Institute) "The Effect of Modulation of Innate Immunity on Tuberculosis Pathogenesis and Response to Antibiotic Treatment" |
9:10 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | Early clinical trials |
| Discussion Leader: Ann Ginsberg (Global Alliance for TB Drug Development) |
9:00 am - 9:45 am | Clifton Barry (NIH) "in vivo imaging of tuberculosis and the response to chemotherapy: PET as a surrogate marker for drug efficacy" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:00 am | Ngozi Erondu (Global Alliance for TB Drug Development) "Update on the clinical development of PA-824" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Andreas Diacon (University of Stellenbosch) "Perspective on TMC207" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Alain Baulard (Pasteur Institut, Lille) "EthR inhibitors boost antituberculous activity of ethionamide" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | How should new drugs be tested? |
| Discussion Leader: Eric Rubin (Harvard) |
7:30 pm - 7:55 pm | Lawrence Geiter (Otsuka Pharmaceuticals) "Practical issues in the implementation of tuberculosis clinical trials: lessons learned and challenges faced in the implementation of a phase IIB trial" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Mel Spigelman (Global Alliance for TB Drug Development) "Innovative approaches to the clinical development of new anti-tuberculosis agents" |
8:30 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Chris Lipinski (Melior Discovery) "August 21, 2009: Where is TB drug discovery today?" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |