SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Targeting drug-resistant tuberculosis |
| Discussion Leader: Stewart Cole (EPFL) |
7:40 pm - 8:20 pm | Mario Raviglione (Stop TB, WHO)
"Global TB targets" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Floyd Romesberg (Scripps Research Institute)
"Why are there so few drug targets?" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Potential new targets for drug discovery |
| Discussion Leader: Sabine Ehrt (Cornell University) |
9:00 am - 9:25 am | Jun-Rong Wei (Harvard School of Public Health)
"New approaches to target validation" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Luke Alderwick (University of Birmingham)
"The Ethambutol target-EmbC is a Lectin-like Carbohydrate Binding Module" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo |
10:30 am - 10:55 am | Mamadou Daffe (CNRS Toulouse)
"Targeting FadD32 & PKS13" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Mary Jackson (Colorado State University)
"Potency and mode of action of adamantyl ureas against M. tuberculosis" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Yap Boum (Epicentre Mbara Research Base) "Antimicrobial compounds targeting the unique reaction mechanism of thymidylate synthase ThyX" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time |
5:30 pm - 7:30 pm | Metabolism as a target |
| Discussion Leader: John Blanchard (Albert Einstein College of Medicine) |
5:30 pm - 5:55 pm | Gregory Cook (University of Otago)
"The VapBC toxin-antitoxin regulates metabolic flux in M. smegmatis by targeting mRNA transcripts that transport and metabolize sugars" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Kyu Rhee (Cornell University)
"Metabolomics" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:20 pm | Pedro Alzari (Institut Pasteur)
"Protein kinases and central metabolism" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New approaches/new leads |
| Discussion Leader: Tanya Parish (Infectious Disease Research Institute) |
9:00 am - 9:25 am | Claudia Sala (EPFL)
"New models for latency drug discovery" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Shekhar Mande (Centre For DNA Fingerprinting and Diagnostics) "Genome-wide interactions and communication signals during mycobacterial latency" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Carl Nathan (Cornell University)
"Killing non-replicating M. tuberculosis" |
10:55 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Charles Thompson (University of British Columbia) "Synergistic drug combinations for tuberculosis therapy identified by a novel high throughput screen" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | David Sherman (Seattle Biomedical Research Institute)
"Integrated methods for TB drug discovery" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Screening for new antibiotics |
| Discussion Leader: Stewart Cole (EPFL) |
5:30 pm - 5:55 pm | Helena Boshoff (NIAID)
"New screening approaches" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Lixin Zhang (Institute of Microbiology, Beijing) "Bioprospecting natural products for potential anti-TB drugs" |
6:25 pm - 6:35 pm | Discussion |
6:35 pm - 7:10 pm | Mike Foley (Broad Institute)
"Diversity oriented synthesis and screening" |
7:10 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New compounds/delivery systems |
| Discussion Leader: Véronique Dartois (Novartis Institute for Tropical Disease) |
9:00 am - 9:25 am | Ute Moellmann (Alere Technologies GmbH, Jena)
"1,4 Benzothiazinones - preclinical development" |
9:25 am - 9:35 am | Discussion |
9:35 am - 9:50 am | Giancarlo Biagini (Liverpool School of Tropical Medicine) "Targeting the type II NADH:menaquinone oxidoreductase of Mycobacterium tuberculosis: towards a novel drug against latent infection" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Alfonso Mendoza (GSK)
"InhA: Old target, new drugs" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Jacques Grosset (Johns Hopkins Medical School)
"Optimizing dosing and animal models" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | Adjuncts to TB therapy |
| Discussion Leader: Gilla Kaplan (Public Health Research Institute, Newark) |
5:30 pm - 5:55 pm | Thomas Hawn (Washington University, Seattle)
"Host susceptibility genes" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | David Tobin (Duke University)
"Eicosanoid balance and TB susceptibilty" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:20 pm | Kanury V.S. Rao (ICGEB, New Delhi)
"Targeting the macrophage machinery aiding M. tuberculosis" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Early clinical trials |
| Discussion Leader: Ken Duncan (Bill & Melinda Gates Foundation) |
9:00 am - 9:40 am | Tim Sterling (Vanderbilt)
"TBTC Study 26" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Bala Subramanian (AZI) "AZD 5847 - phase I experience" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Bob Wallis (Pfizer) "Biomarker acceleration of development of PNU-100480" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session III |
5:30 pm - 7:30 pm | Clinically testing new drugs |
| Discussion Leader: Eric Rubin (Harvard) |
5:30 pm - 6:00 pm | Gerhard Walzl (Stellenbosch University)
"Biomarkers and chemotherapy" |
6:00 pm - 6:15 pm | Discussion |
6:15 pm - 6:45 pm | Willem Hanekom (University of Cape Town)
"Clinical trials - the modalities" |
6:45 pm - 7:00 pm | Discussion |
7:00 pm - 7:30 pm | Chris Lipinski (Melior Discovery)
"Where is TB drug discovery today?" |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |