SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:50 pm | The Changing Landscape of TB Treatment |
| Discussion Leader: David Sherman (Seattle Biomedical Research Institute) |
7:40 pm - 8:30 pm | Koen Andries (Tibotec)
"Discovery and Development of Bedaquiline: A Rocky Road" |
8:30 pm - 8:50 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Biology: insights, targets and tools |
| Discussion Leader: Chris Sassetti (University of Massachusetts) |
9:00 am - 9:25 am | Kim Lewis (Northeastern University)
"Persisters: approaches to eradicate specialized survivor cells" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Jyothi Rengarajan (Emory University School of Medicine)
"Targeting an M. tuberculosis immunomodulatory serine protease for adjunctive therapy" |
10:00 am - 10:10 am | Discussion |
10:10 am | Group Photo / Coffee Break |
10:40 am - 11:05 am | Dirk Schnappinger (Weill Cornell Medical College)
"Genetic approaches to facilitate TB drug development" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Christoph Grundner (Seattle Biomedical Research Institute)
"Targeting a phosphoswitch of Mtb replication" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Sarah Fortune (Harvard School of Public Health)
"(Avoiding) resistance is futile" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Targets |
| Discussion Leader: Sabine Ehrt (Weill Cornell Medical College) |
5:30 pm - 5:55 pm | Luiz Pedro de Carvalho (MRC)
"Metabolomic applications for target engagement in antibiotic research" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Omonike Olaleye (Texas Southern University)
"Methionine aminopeptidase as a potential chemotherapeutic target for tuberculosis" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:20 pm | Stewart Cole (EPFL, École polytechnique fédérale de Lausanne)
"Promiscuous targets" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Screening tools and approaches |
| Discussion Leader: Thomas Dick (National University of Singapore) |
9:00 am - 9:25 am | Tom Blundell (University of Cambridge)
"Understanding and targeting the Mtb proteome: the application of computational and fragment-based approaches" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ruben Tommasi (AstraZeneca)
"The search for novel antibacterials: a summary of AZ's screening and lead finding approaches, lessons learned and outlook for the future" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Manfred Auer (University of Edinburgh)
"Chemical Systems Biology and Biophysics using Tagged One-Bead One-Compound Combinatorial Chemical Libraries" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Joel Freundich (University of Medicine and Dentistry, New Jersey)
"Bayesian models for antitubercular drug discovery" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Tim Wells (Medicines for Malaria Venture)
"Drug discovery and development for malaria control and elimination" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Target-based or phenotypic screening? You be the judge |
| Discussion Leader: Ken Duncan (Bill and Melinda Gates Foundation) |
5:30 pm - 6:00 pm | Courtney Aldrich (University of Minnesota School of Pharmacy)
"Targeting biotin metabolism in Mycobacterium tuberculosis" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:40 pm | Brian Vanderven (Cornell University)
"Targeting the intracellular replication of M. tuberculosis for drug discovery" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:20 pm | Tanya Parish (Infectious Disease Research Institute)
"Squaring the circle - using phenotypic screens to find targeted compounds?" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Compounds |
| Discussion Leader: David Barros (GlaxoSmithKline) |
9:00 am - 9:25 am | Kelly Chibale (Institute of Infectious Disease and Molecular Medicine, S. Africa)
"Medicinal chemistry progression of phenotypic HTS hits for TB from SoftFocus libraries" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Giovanna Poce (Sapienza Università di Roma)
"BM212-derived MmpL3 inhibitors enabling new possibilities for the treatment of TB" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:10 am | Michael Shultz (Novartis)
"Optimization of binding enthalpy using lipophilic efficiency" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Marvin Miller (University of Notre Dame)
"Syntheses and evaluation of new anti-tuberculosis agents Inspired by studies of mycobacterial iron assimilation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Anil Koul (Janssen Research and Development, Johnson and Johnson Pharmaceuticals)
"Delayed bactericidal response to bedaquiline involves extensive remodeling of metabolic pathways in Mycobacterium tuberculosis" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | EBA - what it does and doesn't measure |
| Discussion Leader: Paul van Helden (Stellenbosch University) |
5:30 pm - 6:00 pm | Andreas Diacon (Stellenbosch University)
"The EBA -- what it does and doesn't measure" |
6:00 pm - 6:10 pm | Discussion |
6:10 pm - 6:40 pm | Carol Nacy (Sequella)
"Developing new drugs for TB: do they all need to act like INH?" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:20 pm | Bavesh Kana (University of Witwatersrand)
"Differential bacterial culturability in tuberculous sputum: Can we look at both sides of the same coin at once?" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 8:00 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drugs in humans and other animals |
| Discussion Leader: Gerry Davies (Liverpool School of Tropical Medicine) |
9:00 am - 9:25 am | Khisimuzi Mdluli (TB Alliance)
"Identifying novel treatment shortening regimens for DS/DR tuberculosis - from preclinical models to clinical trials" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Eric Nueremberger (Johns Hopkins University)
"Animal efficacy models for TB drug development: trials and tribulations" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Charles Peloquin (University of Florida)
"Accounting for Variability: Pharmacokinetics in TB Treatment" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Brendan Prideaux (PHRI-Rutgers University)
"Assessing lesion-specific pharmacokinetics of tuberculosis drugs using mass spectrometry imaging" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Lalita Ramakrishan (University of Washington)
"Macrophage-induced bacterial efflux pumps as mediators of drug tolerance and virulence" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Regimens, trials and insights |
| Discussion Leader: Khisimuzi Mdluli (TB Alliance) |
5:30 pm - 5:55 pm | Nick Paton (NUHS)
"Trials of new treatment strategies for drug sensitive TB: challenges in design and implementation" |
5:55 pm - 6:10 pm | Discussion |
6:10 pm - 6:35 pm | Robert Wallis (Pfizer)
"Culture status at 2 months as a predictor of required treatment duration of new TB regimens" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Clif Barry (National Institute of Allergy and Infectious Disease)
"The future of oxazolidinones in the treatment of TB"
|
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:30 pm | Meeting summary and wrap-up |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |