Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Need for New Drugs Against Tuberculosis
Discussion Leader: Tanya Parish (Infectious Disease Research Institute, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:40 pm
Graeme Meintjes (University of Cape Town, South Africa)
"New Drugs for TB: Clinical and Programmatic Needs and Challenges"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:25 pm
Valerie Mizrahi (Institute of Infectious Disease and Molecular Medicine, South Africa)
"Harnessing Biological Insight to Accelerate TB Drug Discovery"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Challenges in Clinical Trials and
Biomarkers for Tuberculosis
Discussion Leader: Anna Upton (TB Alliance, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Terry Blaschke (Stanford University, USA)
"New Facts Regarding, and Novel Approaches to, TB Treatment Adherence: Implications for Clinical Practice and Drug Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Gerhard Walzl (Stellenbosch University, South Africa)
"Developing Treatment Response Biomarkers"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Debra Hanna (Critical Path Institute, USA)
"Critical Path to TB Drug Regimens: Integrating Data to Drive Innovation in Translational Science for TB Drug Regimen Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Gerry Davies (University of Liverpool, United Kingdom)
"PreDiCT-TB: Learning from Preclinical Data"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Michael Lyons (Colorado State University, USA)
"Dose Optimization as Engineering Design: Application to Regimen-Based Development for Tuberculosis"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lead
Optimization and Clinical Evaluation
Discussion Leader: Lluis Ballell-Pages (GlaxoSmithKline, Spain)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Nader Fotouhi (TB Alliance, USA)
"Towards Safer Oxazolidinones as Components of Universal Regimens for TB"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Vadim Makarov (A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Russia)
"Clinical Trials with the Novel Drug Candidate PBTZ169"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
David Barros (GlaxoSmithKline R&D, Spain)
"GSK070: From Bench to Man. A Novel Clinical Candidate for the Treatment of Tuberculosis"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Hit-to-Lead
Optimization and Pharmacokinetics in Early Drug Discovery
Discussion Leader: Kelly Chibale (University of Cape Town, South Africa)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Jeffrey Aube (University of North Carolina at Chapel Hill, USA)
"Seeking TB-Active Cephalosporins"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Jason Sello (Brown University, USA)
"Beyond the Conventional: Novel Molecules and Strategies for the Treatment of Tuberculosis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
Selected from Poster Abstracts: Samantha Wellington (Harvard University, USA)
"Identification of a Specific, Allosteric Small-Molecule Inhibitor of Mycobacterium tuberculosis Tryptophan Synthase"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Benoit Deprez (Institut Pasteur, France)
"Outsmarting Resistance in Tuberculosis SMARt Compounds: From Lead to Drug Candidate"
11:35 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Cynthia Dowd (George Washington University, USA)
"Hitting Malaria and Tuberculosis with the Same Bullet? Dxr Inhibitors as Antimicrobials"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Natural
Products in Antibacterial Discovery
Discussion Leader: Bree Aldridge (Tufts University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Ronald Quinn (Griffith University, Australia)
"Natural Products: Integrating Phenotype, Fragment, and Target Screening Towards Mechanism of Action"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Sylvie Garneau-Tsodikova (University of Kentucky, USA)
"Novel Aminoglycoside Adjuvants and Stand-Alone Agents to Combat Tuberculosis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Nathan Magarvey (McMaster University, Canada)
"Clustering and Assembly of Genetically Inferred Antibiotics"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolism
as a Target
Discussion Leader: Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Laura Kiessling (University of Wisconsin-Madison, USA)
"Chemical Probes of Cell Envelope Biosynthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Lindsay Eltis (University of British Columbia, Canada)
"Cholesterol Catabolism - A Ring-Side Seat"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Anthony Baughn (University of Minnesota, USA)
"Stress Response as a Driver of Pyrazinamide Susceptibility"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
Selected from Poster Abstracts: Dany Beste (University of Surrey, United Kingdom)
"Intracellular Mycobacterium tuberculosis Requires Two Gateways into Gluconeogenesis and Multiple CO2 Fixation Routes"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Nagasuma Chandra (Indian Institute of Science, India)
"Reversing Antibiotic Resistance Through Strategic Combinations"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Promiscuous
Targets, Drugs, and Hits
Discussion Leader: Kevin Pethe (Lee Kong Chian School of Medicine, Nanyang Technologicial University, Singapore)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Jonathan Baell (Monash University, Australia)
"Resource-Wasting Pan Assay Interference Compounds (PAINS): Readily Found in Any Screen and Highly Relevant to TB Drug Discovery"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
Adrie Steyn (Kwazulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), South Africa)
"Bioenergetic Rewiring: Turning the Respiratory Flexibility of M. tuberculosis Against Itself"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Selected from Poster Abstracts: Erik Hasenoehrl (Albert Einstein College of Medicine, USA)
"Cytochrome bd Oxidase and the CydDC Transporter: New Drug Targets at the Heart of Redox Homeostasis in Mycobacterium tuberculosis "
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:50 pm
Mary Jackson (Colorado State University, USA)
"MmpL3: Therapeutic Potential and Mechanism of Inhibition"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Host-Directed Therapies and
Host-Pathogen Interactions
Discussion Leader: Gilla Kaplan (Bill & Melinda Gates Foundation, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Priscille Brodin (INSERM / Institut Pasteur de Lille, France)
"Investigation of a Drug Candidate with Enhanced Potency Against Intracellular M. tuberculosis "
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
Robert Abramovitch (Michigan State University, USA)
"Small Molecules that Inhibit Mycobacterium tuberculosis Environmental Sensing and Virulence"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Pooja Gopal (National University of Singapore, Singapore)
"From Mechanisms of Resistance to a Mechanism of Action for Pyrazinoic Acid and Its Prodrug Pyrazinamide"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Veronique Fontaine (Université Libre de Bruxelles, Belgium)
"Investigation of the Role of GroEL-1 and PDIM in Antibiotic Resistance leads to Repurpose Drugs as Antimycobacterial Candidates"
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Thomas Hawn (University of Washington, USA)
"Host-Directed Therapies in Macrophages and TB"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Outside the Norm: Non-Traditional
Approaches
Discussion Leader: Helena Boshoff (National Institutes of Health, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Nitin Baliga (Institute for Systems Biology, USA)
"Network Strategy to Accelerate Discovery of Combination Therapy Against Drug Resistance in TB"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Selected from Poster Abstracts: Yesha Patel (Indian Institute of Technology, Bombay, India)
"Oxidative Stress: A Potential Target for Combination Therapy Against Mycobacteria"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Selected from Poster Abstracts: Magdalena Bielecka (University of Southampton, United Kingdom)
"A Bioengineered 3-Dimensional Cell Culture Platform for Developing Novel Therapeutic Approaches for Tuberculosis"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Giulia Manina (Institut Pasteur, France)
"Targeting Phenotypic Variation in Mycobacteria to Improve Drug-Mediated Killing"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure