Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on TB Drug Development
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
"Surviving XDR: Human Impact of Drug Resistance"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:55 pm
"The Search for Next Generation Antimalarials for Elimination"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Drugs for Activity Against the Pathogen
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Disarming Mycobacterium tuberculosis Antibiotic Tolerance and Resistance"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Siderophore Import by an Unusual Mycobacterial ABC Exporter"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Sugar Uptake and Metabolism in Mycobacterium tuberculosis : From Structure/Function to Potential Drug Targets"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Rationalizing Rational Drug Development: An Intrabacterial Perspective on Compound SAR"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Cephalosporins Cidal for both Replicating and Non-Replicating M. tuberculosis : Dual Pharmacophores and Modes of Action"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Attributes of an Ideal TB Drug
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Drug Delivery Strategies for Targeting Drugs to the Lungs"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"No Transporters Means No Transport: The Absolute Role of SLCs in the Uptake and Efficacy of Pharmaceutical Drugs"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
"Caseum: The Alpha and Omega of TB"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Treatment Shortening Potential of Targets in Cell Wall Biosynthesis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Lipid Metabolism as a Reservoir for the Identification of New Antimycobacterial Compounds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Inhibitors of the Mycobacterium tuberculosis Cell Wall Biosynthesis to Replace Isoniazid in the Mtb Drug Regime"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Betalactams for TB: The Bridge to the Clinic"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Inhibitors of Cell Wall Synthesis: Do They Have a Place in Novel TB Regimens?"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Direct Inhibitors of InhA Against Mycobacterium tuberculosis : Development of 4-Hydroxy-2-Pyridones as Anti-TB Agents"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening Potential of Targets in Transcription/Translation
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Predicting Rifampicin Tolerance in Clinical Isolates by Genetic Association"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Novel Approaches to Targeting M. tuberculosis RNA Polymerase"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"OTB-658, a Drug Candidate for DR-TB Treatment"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Novel Oxazolidinone-Class Protein Synthesis Inhibitors with Improved Safety Profiles"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Treatment Shortening Potential of Non-Traditional Drug Targets
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Allosteric De-Regulation of Metabolic Pathways as a Novel Antibiotic Strategy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"M. tuberculosis Proteostasis Network: Role in Drug Resistance"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"The 'Trp' from Lead to Pre-Clinical Candidate"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Inhibition of the Biosynthetic Pathways for Essential Amino Acids"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Targeting Mycobacterial DNA Replication"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Enrichment of the Pipeline by Natural Products
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
"Discovery and Evaluation of Antitubercular Natural Products from Soil Bacteria"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
"Natural Product and Synthetic Biology Routes to New Antimycobacterial Agents"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
"Development of Spectinamide 1810, a TB-Active Analog of the Natural Product Spectinomycin"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Host-Dependent and Host-Directed Therapies
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Host-Dependent Targets: Using Complex Host Biology in Our Favor"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Genetic Determinants of Therapeutic Efficacy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Anti-Inflammatory and Anti-Microbial Host-Directed TB Therapies"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Siderophore-Dependent Inhibitors of Mycobacterium tuberculosis "
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Diazabicyclooctanes (DBOs) for Inhibition of Peptidoglycan Synthesis in Mycobacterium tuberculosis "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening and Clinical Trials Innovation
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"NexGen EBA: Assessing Sterilizing Potential of New Drugs and Regimens"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
"Novel Strategies and Outcome Measures in TB Clinical Trials"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure