Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on TB Drug Development
Discussion Leader: Valerie Mizrahi (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:05 pm
Enrique Delgado (Spain)
"Surviving XDR: Human Impact of Drug Resistance"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:55 pm
Elizabeth Winzeler (University of California, San Diego, USA)
"The Search for Next Generation Antimalarials for Elimination"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Optimizing Drugs for Activity Against the Pathogen
Discussion Leader: Kelly Chibale (University of Cape Town, South Africa)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Christina Stallings (Washington University School of Medicine, USA)
"Disarming Mycobacterium tuberculosis Antibiotic Tolerance and Resistance"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Markus Seeger (University of Zurich, Switzerland)
"Siderophore Import by an Unusual Mycobacterial ABC Exporter"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Elizabeth Fullam (University of Warwick, United Kingdom)
"Sugar Uptake and Metabolism in Mycobacterium tuberculosis : From Structure/Function to Potential Drug Targets"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Kyu Rhee (Weill Cornell Medicine, USA)
"Rationalizing Rational Drug Development: An Intrabacterial Perspective on Compound SAR"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Shuyi Ma (Seattle Children's Research Institute, USA)
"Network Stress Tests Reveal Novel Drug Potentiators in Mycobacterium tuberculosis "
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Landys Lopez Quezada (Weill Cornell Medicine, USA)
"Cephalosporins Cidal for both Replicating and Non-Replicating M. tuberculosis : Dual Pharmacophores and Modes of Action"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Valerie Mizrahi (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Attributes of an Ideal TB Drug
Discussion Leader: Sabine Ehrt (Weill Cornell Medicine, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Ben Forbes (King's College London, United Kingdom)
"Drug Delivery Strategies for Targeting Drugs to the Lungs"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Douglas Kell (University of Liverpool, United Kingdom)
"No Transporters Means No Transport: The Absolute Role of SLCs in the Uptake and Efficacy of Pharmaceutical Drugs"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Veronique Dartois (Hackensack Meridian Health Center for Discovery and Innovation, USA)
"Caseum: The Alpha and Omega of TB"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
Treatment Shortening Potential of Targets in Cell Wall Biosynthesis
Discussion Leader: David Sherman (Center for Global Infectious Disease Research / University of Washington, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Hugo Gramajo (Institute of Molecular and Cell Biology of Rosario (IBR-CONICET), Argentina)
"Lipid Metabolism as a Reservoir for the Identification of New Antimycobacterial Compounds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
H. Michael Petrassi (The Scripps Research Institute, USA)
"Inhibitors of the Mycobacterium tuberculosis Cell Wall Biosynthesis to Replace Isoniazid in the Mtb Drug Regime"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Elana Van Brakel (TASK Applied Science, South Africa)
"Betalactams for TB: The Bridge to the Clinic"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Eric Nuermberger (Johns Hopkins University, USA)
"Inhibitors of Cell Wall Synthesis: Do They Have a Place in Novel TB Regimens?"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Renhe Liu (Global Health Drug Discovery Institute, China)
"Direct Inhibitors of InhA Against Mycobacterium tuberculosis : Development of 4-Hydroxy-2-Pyridones as Anti-TB Agents"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening Potential of Targets in Transcription/Translation
Discussion Leader: Bavesh Kana (University of the Witwatersrand, South Africa)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Babak Javid (Tsinghua University School of Medicine, China)
"Predicting Rifampicin Tolerance in Clinical Isolates by Genetic Association"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
George Garcia (University of Michigan, USA)
"Novel Approaches to Targeting M. tuberculosis RNA Polymerase"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Haihong Huang (Institute of Materia Medica, Chinese Academy of Medical Sciences / Peking Union Medical College, China)
"OTB-658, a Drug Candidate for DR-TB Treatment"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Brendan Crowley (MSD, USA)
"Novel Oxazolidinone-Class Protein Synthesis Inhibitors with Improved Safety Profiles"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Treatment Shortening Potential of Non-Traditional Drug Targets
Discussion Leader: Alain Baulard (Institut Pasteur de Lille, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom)
"Allosteric De-Regulation of Metabolic Pathways as a Novel Antibiotic Strategy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Kristin Burns-Huang (Weill Cornell Medicine, USA)
"M. tuberculosis Proteostasis Network: Role in Drug Resistance"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Lourdes Encinas (GlaxoSmithKline, Spain)
"The 'Trp' from Lead to Pre-Clinical Candidate"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Emily Parker (Victoria University of Wellington, New Zealand)
"Inhibition of the Biosynthetic Pathways for Essential Amino Acids"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Digby Warner (University of Cape Town, South Africa)
"Targeting Mycobacterial DNA Replication"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Enrichment of the Pipeline by Natural Products
Discussion Leader: Cynthia Dowd (George Washington University, USA)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Jennifer Herrmann (Helmholtz Institute for Pharmaceutical Research Saarland, Germany)
"Discovery and Evaluation of Antitubercular Natural Products from Soil Bacteria"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Gerry Wright (McMaster University, Canada)
"Natural Product and Synthetic Biology Routes to New Antimycobacterial Agents"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:30 pm
Michelle Butler (Microbiotix, Inc., USA)
"Development of Spectinamide 1810, a TB-Active Analog of the Natural Product Spectinomycin"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Miaomiao Liu (Griffith University, Australia)
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Host-Dependent and Host-Directed Therapies
Discussion Leader: JoAnne Flynn (University of Pittsburgh School of Medicine, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Russell (Cornell University, USA)
"Host-Dependent Targets: Using Complex Host Biology in Our Favor"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Chris Sassetti (University of Massachusetts Medical School, USA)
"Genetic Determinants of Therapeutic Efficacy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
Robert Wallis (Aurum Institute, South Africa)
"Anti-Inflammatory and Anti-Microbial Host-Directed TB Therapies"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Michael Niederweis (University of Alabama at Birmingham, USA)
"Siderophore-Dependent Inhibitors of Mycobacterium tuberculosis "
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Zainab Edoo (INSERM, France)
"Diazabicyclooctanes (DBOs) for Inhibition of Peptidoglycan Synthesis in Mycobacterium tuberculosis "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Treatment Shortening and Clinical Trials Innovation
Discussion Leader: Gilla Kaplan (University of Cape Town, South Africa)
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
Clifton Barry (National Institute of Allergy and Infectious Diseases, NIH, USA)
"NexGen EBA: Assessing Sterilizing Potential of New Drugs and Regimens"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
Nick Paton (National University of Singapore, Singapore)
"Novel Strategies and Outcome Measures in TB Clinical Trials"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure