Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Applying New Technologies and Recent Learnings From TB Drug Discovery and Development, Towards Next Generation Treatments
Discussion Leader: Sarah Fortune (Harvard T.H. Chan School of Public Health, United States)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
Stewart Cole (Institut Pasteur, France)
"Reminiscences of the Gang of Four"
8:35 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Anastasia Koch (Eh!woza & University of Cape Town, South Africa)
"Public Engagement as Essential Science: From TB to Covid and Back Again"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Improving TB Chemotherapy Through Translational Science and Clinical Trial Design
Discussion Leader: Kelly Dooley (Vanderbilt University Medical Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
David Barros (GSK , Spain)
"Accelerating the Development of New TB Drug Regimens: Adaptive Clinical Trials to De-Risk Late Attrition"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Rada Savic (UCSF, United States)
"Translating TB Treatment Response: Knowledge Integration Platform for Development of Novel Regimens"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Nicholas Walter (University of Colorado Denver, United States)
"Beyond Burden: Evaluating Drug Effect Based on M. tuberculosis Cellular Processes"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Robert J Wilkinson (Francis Crick Institute, United Kingdom)
"Understanding and Improved Drug Management of Severe Extrapulmonary Tuberculosis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Gerhard Walzl (Stellenbosch University, South Africa)
"Attempts to Shorten Treatment Duration on Current Drugs: The End of That Road?"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Bree Aldridge (Tufts University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Designing and Evaluating TB Drug Combinations Using Preclinical Data
Discussion Leader: Jurriaan De Steenwinkel (Erasmus MC, The Netherlands)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Bree Aldridge (Tufts University, United States)
"Design and Patterns of Optimized Drug Combinations for TB"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Sophia Gessner (University of Cape Town, South Africa)
"The Mycobacterial ImuA'-ImuB-DnaE2 Mutasome: Composition and Recruitment in Live Cells"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Tejan Lodhiya (IISER Tirupati, India, India)
"Understanding the Complex Mechanisms Involved in Antibiotic-Induced Cell Death in Mycobacteria"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
Alexander Berg (Allucent, United States)
"A Stochastic Simulation-Based Approach to Inform Relapsing Mouse Model Study Design"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Finding and Optimizing New Lead Compounds
Discussion Leader: Brendan Crowley (Merck, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Laura Cleghorn (Drug Discovery Unit, University of Dundee, United Kingdom)
"Lysyl tRNA Synthetase – A Novel Drug Target for TB"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Kamel Djaout (Institut Pasteur de Lille, France)
"Combination of Pretomanid with Booster SMARt-207 to Hypersensitize Sensitive and Resistant Strains"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Dirk Lamprecht (Janssen Pharmaceutica, Belgium)
"Optimization of MenG Inhibitors Towards the Discovery of Clinical Candidates for TB"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Elena Fonfria (Exscientia, United Kingdom)
"AI-Driven Design of Bispecific Small Molecules for Tuberculosis"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Natalya Serbina (TB Alliance, United States)
"Disrupting Protein Homeostasis in Mtb: Novel Modulators of the Clp Protease System"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Profiling Drugs and Leads
Discussion Leader: Khisimuzi Mdluli (Bill and Melinda Gates Medical Research Institute, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Laura Kiessling (Massachusetts Institute of Technology, United States)
"Chemical Probes of the Mycobacterial Cell Envelope"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Neeraj Dhar (University of Saskatchewan, Canada)
"Single-Cell PK/PD Approaches to Advance TB Drug Discovery"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Max Gutierrez (The Francis Crick Institute, United Kingdom)
"Host Cell Environments and Antibiotic Efficacy in Tuberculosis"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Approaches to Seeking New Chemical Matter
Discussion Leader: Christine Roubert (Evotec ID (Lyon) SAS , France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Deborah Hung (Harvard Medical School and Massachusetts General Hospital, United States)
"Systems Chemical Biology for TB Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Akane Kawamura (Newcastle University, United Kingdom)
"Cyclic Peptide Hit Discovery Platform"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Robert Abramovitch (Michigan State University, United States)
"Targeting Mycobacterium Tuberculosis Adaptation to Environmental Cues"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Anthony Keefe (X-Chem Inc., United States)
"DNA-Encoded Chemistry and its Application to TB Targets"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Beatriz Rodriguez-Miquel (GSK, Spain)
"Unraveling the Mystery of Rho"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Alternative Strategies to Cure TB
Discussion Leader: Thomas Dick (Hackensack Meridian Health, United States)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Graham Hatfull (University of Pittsburgh, United States)
"Mycobacteriophages and Their Therapeutic Potential"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:05 pm
Natalia Freund (Tel Aviv University, Israel)
"Human Antibodies Targeting a Transporter Mediate Protection Against Tuberculosis"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:40 pm
Francesca Ester Morreale (Francis Crick institute, United Kingdom)
"Enabling Targeted Protein Degradation in Mycobacteria"
7:40 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Advancing Our Understanding of TB and Mtb to Improve TB Chemotherapy
Discussion Leader: Luiz Pedro Carvalho (UF Scripps Biomedical Research, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Jeremy Rock (Rockefeller University, United States)
"Collateral Vulnerabilities of Drug-Resistant M. Tuberculosis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
Erin McCaffrey (Stanford University, United States)
"Dissecting the Immunological Ecosystem of TB to Identify Targets for Host-Directed Therapy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Michael Glickman (Sloan Kettering Institute, United States)
"Microbiome Dynamics in TB Treatment and Disease Resolution"
11:05 am - 11:15 am
Discussion
11:15 am - 11:40 am
Maria Lerm (Linköping university, Sweden)
"High-Dimensional Approaches to Understanding TB and Identifying New Avenues for Treatment"
11:40 am - 11:50 am
Discussion
11:50 am - 12:15 pm
Greg Cook (University of Otago, New Zealand)
"Defining Therapeutic Vulnerabilities in Drug-Resistant Strains of Mycobacterium Tuberculosis"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Drug Tolerance, Resilience, and Resistance
Discussion Leader: Valerie Mizrahi (University of Cape Town, South Africa)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:30 pm
Sarah Fortune (Harvard T.H. Chan School of Public Health, United States)
"Protecting New Drugs Against Highly Prevalent Stepping Stone Mutations"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Saurabh Chugh (Translational Health Science and Technology Institute, India)
"Polyphosphate Kinase-1 Regulates Bacterial and Host Metabolic Pathways Involved in Pathogenesis of Mycobacterium Tuberculosis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Charlie Pyle (Duke University, United States)
"EMP2 is the Foundation of Mycobacterial Granuloma Cellular Infrastructure"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
David Alland (Rutgers - New Jersey Medical School, United States)
"Bacterial Heterogeneity in Mycobacterium Tuberculosis Populations: Threats and Opportunities for Drug Treatment"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure