| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session: How to Find Mycobacterium tuberculosis' Achilles' Heel |
| Discussion Leaders: Eachan Johnson (Broad Institute of MIT and Harvard, USA) and Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) |
| 3:15 pm - 3:45 pm | Dirk Schnappinger (Weill Cornell Medical College, USA)
"Genetic Approaches to Facilitate TB Drug Development" |
| 3:45 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | New Targets and Their Evaluation |
| Discussion Leaders: Eleni Pitta (University of Antwerp, Belgium) and Carolina Trujillo (Weill Cornell Medical College, USA) |
| 5:30 pm - 5:50 pm | Vijay Soni (Birla Institute of Technology and Science, India)
"Mycobacterium
tuberculosis N-Acetyl-Glucosamine-1-Phosphate
Uridyltransferase (glmU) Is Critical for Survival Both in Early and Late
Phase of Infections" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Joanna Evans (University of Cape Town, South Africa)
"A Pathway Approach to Identifying Vulnerable and Bactericidal Targets in Coenzyme A Biosynthesis in Mycobacterium tuberculosis" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Julien Vaubourgeix (Weill Cornell Medical College, USA)
"Asymmetric Distribution of Irreversibly Oxidized, ClpB-Associated Proteins in Stressed Mycobacteria" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Wilfried Moreira (National University of Singapore, Singapore)
"A Target Mechanism-Based Whole Cell Screen Identifies Bortezomib as an Inhibitor of Caseinolytic Protease in Mycobacteria" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Keynote Session: How Do Drugs Get to Where We Need Them to Be? / Improving Current Strategies |
| Discussion Leaders: Tania Lupoli (Weill Cornell Medical College, USA) and Santiago Ramon Garcia (The University of British Columbia, Canada) |
| 9:00 am - 9:30 am | Veronique Dartois (New Jersey Medical School, USA)
"Pharmacokinetics, Pharmacodynamics and Tissue Distribution of Tuberculosis Drugs" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Vaibhav Singh Bais (Indian Institute of Technology Kanpur, India)
"Investigating the Inhibitory Potential of 2-Aminopurine Metal Complexes Against PknB" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Jonathan Cox (University of Birmingham, United Kingdom)
"Changing
Strategies in Elucidating the Mode of Action of New Anti-Tubercular Compounds" |
| 10:35 am - 10:45 am | Discussion |
| 10:45 am - 10:55 am | Fraser Cunningham (GlaxoSmithKline, Spain)
"Open Lab Foundation" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Novel Non-Traditional Strategies |
| Discussion Leaders: Maikel Boot (VU University Medical Center, The Netherlands) and Helena Boshoff (National Institutes of Health, USA) |
| 1:30 pm - 1:50 pm | Xingji Zheng (University of British Columbia, Canada)
"Natural Compounds Active Against Mycobacterium tuberculosis PtpA" |
| 1:50 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Kelly Flentie (Washington University in St. Louis School of Medicine, USA)
"Chemical Dissection of the Contribution of Lipid Composition Changes to Mycobacterium tuberculosis Persister Formation" |
| 2:20 pm - 2:30 pm | Discussion |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
