Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: The Changing Face of TB Drug Discovery
Discussion Leaders: Luiz Pedro Carvalho (The Francis Crick Institute, United Kingdom) and Magdalena Bielecka (University of Southampton, United Kingdom)
3:15 pm - 3:45 pm
Stewart Cole (Ecole Polytechnique Federale de Lausanne - EPFL, Switzerland)
"The Changing Face of TB Drug Discovery"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Evaluating Mechanisms of Resistance and Overcoming Them
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and modulate factors that confer drug resistance.
Discussion Leaders: Anthony Baughn (University of Minnesota, USA) and Vinayak Singh (Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa)
5:30 pm - 5:50 pm
Pooja Gopal (National University of Singapore, Singapore)
"From Mechanisms of Resistance to a Mechanism of Action for Pyrazinoic Acid and Its Prodrug Pyrazinamide"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Abrar Abidi (Institute for Systems Biology, USA)
"The Program of Gene Transcription for the Hypoxia and Reaeration Response in MTB"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sarah Scarry (University of North Carolina at Chapel Hill, USA)
"Strained Amine Heterocycles as Non-Hydrolyzable β-Lactam Surrogates: Mechanistic and Structure-Activity Probes for Mycobacterium tuberculosis "
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Dirk Lamprecht (Africa Health Research Institute, South Africa)
"Synergistic Targeting of Mycobacterium tuberculosis Energy Metabolism"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Identification and Evaluation of Novel Drug Targets
Use of genetic, microbiological, biochemical, and/or chemical techniques to identify and exploit novel drug targets.
Discussion Leaders: Mary Jackson (Colorado State University, USA) and Erik Hasenoehrl (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 am
Samantha Wellington (Harvard University, USA)
"Identification of a Specific, Allosteric Small-Molecule Inhibitor of Mycobacterium tuberculosis Tryptophan Synthase"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Shuyi Ma (Center for Infectious Disease Research, USA)
"Data-Driven Inference of Drug Synergy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Eachan Johnson (Broad Institute of MIT and Harvard, USA)
"A New Platform for Anti-Tubercular Drug Discovery"
10:20 am - 10:30 am
Discussion
10:30 am - 10:50 am
Yesha Patel (Indian Institute of Technology Bombay, India)
"Oxidative Stress: A Potential Target for Combination Therapy Against Mycobacteria "
10:50 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Translation from the Benchtop to the Bedside: Identifying and Combating Mtb in the Community
Translational research towards identifying novel diagnostic tools, vaccines, and getting new therapies into humans.
Discussion Leaders: Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) and Jinghang Xie (Stanford University School of Medicine, USA)
1:30 pm - 1:50 pm
Mireille Kamariza (Stanford University, USA)
"Detection of Live Mycobacteria with a Solvatochromic Trehalose Probe for Point-of-Care Tuberculosis Diagnosis"
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Chandrani Thakur (Indian Institute of Science Bangalore, India)
"Unbiased Identification of Blood-Based Biomarkers for Prognosis of Treatment in Tuberculosis Patients"
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes