Saturday
1:30 pm - 4:30 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Exploring Novel Strategies to Overcome Present Challenges in Combating Tuberculosis
Discussion Leaders: Laura Via (National Institute of Allergy and Infectious Diseases, NIH, USA) and Michael Wuo (Massachusetts Institute of Technology, USA)
3:15 pm - 3:45 pm
Carl Nathan (Weill Cornell Medicine, USA)
"Exploring Novel Strategies to Overcome Present Challenges in Combating Tuberculosis"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Mycobacterial Metabolism and Pathogenesis: Linking Mycobacterial Physiology to Drug Development
Discussion Leaders: Anthony Baughn (University of Minnesota, USA) and Diego Vargas Blanco (Worcester Polytechnic Institute, USA)
5:30 pm - 5:50 pm
Imène Belhaouane (Center for Infection and Immunity of Lille (UMR 8204), France)
"TLR Adaptor Protein Involvement in Early Signalling Pathways Induced in Macrophages by Mycobacterium tuberculosis Infection"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 6:20 pm
Jared Mackenzie (Africa Health Research Institute, South Africa)
"Synergistic Targeting of Mycobacterium tuberculosis Energy Metabolism"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Sille Remm (Institute of Medical Microbiology, University of Zürich, Switzerland)
"Is Mycobacterial Major Facilitator Superfamily Transporter Rv1410 a Drug Efflux Pump?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Sarah Schrader (Weill Cornell Medicine, USA)
"Loss of AminoTransferase ArgD Function Augments Antibiotic Tolerance in Mycobacteria"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
New Therapeutic Targets, Target Identification and Mechanism of Action Studies / Mentorship Component: Career Development
Discussion Leaders: Cynthia Dowd (George Washington University, USA) and Abraham Waldman (Stanford University, USA)
9:00 am - 9:20 am
Jickky Palmae Sarathy (National University of Singapore, Singapore)
"TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Retains On-Target Activity on the Subunits c- and e- of the Mycobacterium tuberculosis F-ATP Synthase"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Neha Dubey (Jawaharlal Nehru University, India)
"Mycobacterium tuberculosis Secretory Peptidyl Prolyl Isomerase A Abets Bacterial Replication and Disease Dissemination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Andrei Gilep (MT-Medicals / Skolkovo Innovation Center, Russia)
"CYP-Targets for Development of New Class of Drug for Tuberculosis (TB) Treatment"
10:20 am - 10:30 am
Discussion
10:30 am - 10:55 am
David Olsen (MSD, USA)
"Scientific Job Hunting/Interviewing: Tips for Those Just Starting the Process"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
In Search of Novel Antitubercular Drugs
Discussion Leaders: Khisimuzi Mdluli (Bill and Melinda Gates Medical Research Institute, USA) and Lisa Standke (Memorial Sloan Kettering Cancer Center / Weill Cornell Medicine, USA)
1:30 pm - 1:50 pm
Zainab Edoo (INSERM, France)
"Diazabicyclooctanes (DBOs) for Inhibition of Peptidoglycan Synthesis in Mycobacterium tuberculosis "
1:50 pm - 2:00 pm
Discussion
2:00 pm - 2:20 pm
Katharigatta Venugopala (Durban University of Technology, South Africa)
"Synthetic Substituted Indolizine Derivatives and Their Anti-TB Activity Against Multidrug-Resistant Strains of Mycobacterium tuberculosis "
2:20 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
