| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Opening Session |
| 7:30 pm - 7:45 pm | Welcome and Introductory remarks: Bradford C. Berk, M.D., Ph.D. / Introductory Comments by GRC Site Staff |
| 7:45 pm - 8:45 pm | Elisabeth Nabel, M.D. (NHLBI, Washington, DC)
"Progeria, Vascular Disease Insights from Premature Aging" |
| 8:45 pm - 9:15 pm | Discussion: Michael Simons, M.D. |
| 9:15 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Extracellular matrix signaling to the vasculature |
| Discussion Leader: Martin Schwartz |
| 9:00 am - 9:20 am | Eleni Tzima (University of North Carolina)
"Mechanosensory complexes in endothelium" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | George Davis, Ph.D. (University of Missouri-Columbia)
"ECM & vascular morphogenesis" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Federico Bussolino (University of Torino)
"ECM & angiogenic signaling" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Martin Schwartz (University of Virginia)
"ECM & endothelial activation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Tatiana Byzova (Cleveland Clinic)
"Integrin signaling" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Xin Zhang (University of Tennessee)
"CD151" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Apoptosis in vascular disease |
| Discussion Leader: Elisabeth Nabel, M.D. (NHLBI, Washington, DC) |
| 7:30 pm - 7:50 pm | Alain Tedgui, Ph.D. (INSERM, Paris, France)
"Endothelial apoptosis and atherosclerosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Slava Korshunov, Ph.D. (University of Rochester, NY)
"Smooth muscle apoptosis and vascular remodeling" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Ira Tabas, M.D., Ph.D. (Columbia University, NY)
"Macrophage apoptosis and atherosclerosis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Mariana Kaplan, M.D. (University of Michigan, MI)
"Endothelial apoptosis and systemic lupus erythematosus" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Endothelial cell junctions and permeability |
| Discussion Leader: Radu Stan, Ph.D. (Dartmouth College, NH) |
| 9:00 am - 9:20 am | Sara M. Weis, Ph.D. (UCSD, San Diego, CA)
"Permeability in cardiovascular disease and cancer" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Masahiro Murakami, M.D., Ph.D. (Dartmouth College)
"FGF regulation of vascular permeability" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Vicki Bautch, Ph.D. (University of North Carolina)
"Role of RasGRP3 in permeability control" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Tanya Mayadas, Ph.D. (Harvard Medical School, Boston, MA)
"Role of Epac1 and Rap in regulation of vascular permeability" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Rebecca Stockton (University of California, San Diego)
"Rap1 signaling" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Patrick Singleton (University of Chicago)
"S1P, lipid rafts and EC barrier function" |
| 12:20pam - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Vascular tube formation |
| Discussion Leader: George Davis, Ph.D. (Texas A&M, TX) |
| 7:30 pm - 7:50 pm | Brent Weinstein, Ph.D. (NIH, Washington)
"In vivo lumen formation in zebra fish" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Donald Ingber, M.D., Ph.D. (Harvard Medical School, Boston)
"Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Donald McDonald, M.D. (University of California - San Francisco)
"ECM guidance tracks in tumor angiogenesis" |
| 8:50 pm - 9:00 pm | Discussion
|
| 9:00 pm - 9:20 pm | Chris Hughes, Ph.D. (University of California - Irvine)
"Stromal-endothelial interactions during tubulogenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Vascular cell differentiation |
| Discussion Leader: Karen Hirschi, Ph.D. (Center for Cell and Gene Therapy, Baylor College of Medicine, Texas) |
| 9:00 am - 9:20 am | Gary Owens, Ph.D. (University of Virginia)
"Myocardin is a key regulator of CarG-dependent transcription" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Mark W. Majesky, Ph.D. (University of North Carolina, Chapel Hill)
"Development of Coronary Vessels" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Patricia D'Amore (The Schepens Eye Research Institute)
"VEGF signaling in adult" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Eli Keshit, Ph.D. (Israel)
"VEGF/SDF-1 cell mobilization and end-organ angiogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Per Lindahl (Sweden)
"Transcriptional networks in endothelial cells" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Keith March (Indiana University)
"Mesenchymal stem cells" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Immunology of the vasculature |
| Discussion leader: Alain Tedgui, Ph.D. (INSERM, Paris, France) |
| 7:30 pm - 7:50 pm | Myron Cybulsky, M.D., Ph.D. (University of Toronto, Canada)
"Inflammation, intimal dendritic cells and atherogenesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Stephen Schwartz, M.D., Ph.D. (University of Washington)
"Monocytes and the vasculature" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Ralph Kelly, M.D., Ph.D. (Genzyme Corp.)
"Innate immunity and the vasculature" |
| 8:50 pm - 9:00 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:00 am - 12:30 pm | Signal transduction and integration |
| Discussion Leader: Gary Gibbons, M.D., Ph.D. (Morehouse School of Medicine, Atlanta, GA) |
| 9:00 am - 9:20 am | Randall Peterson, Ph.D. (Harvard Medical School, Boston, MA)
"Chemical biology and arterial specification" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Michael Simons, M.D. (Dartmouth Medical School - Lebanon, NH)
"Regulation of arterial specification" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Brian G. Petrich, Ph.D. (University of California - San Diego)
"Regulation of integrin activation in vivo" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Primal de Lanerolle (University of Illinois at Chicago)
"Regulation of MLCK by Ras/SRF" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Andrew White (Washington University in St. Louis)
"FGF9/SHH in Pulmonary Capillary development" |
| 11:50 am - 12:00 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Late-breaking presentations |
| Discussion Leaders: Bradford Berk and Michael Simons |
| 7:30 pm - 7:50 pm | Brian Annex (Duke University Medical Center)
"Vascular abnormalities in diabetes" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Stephanie Lehoux (Centre National de la Recherche Scientifique, Paris, France)
“Atherosclerotic plaque regression” |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Frank Giordano (Yale University)
"HIF oxygen sensing in the vessel wall" |
| 8:50 pm - 9:00 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
