Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Paracrine Vascular Signaling
Signals within the vascular wall and between flowing blood and vascular cells that regulate the blood-brain barrier and vascular tone will be discussed.
Discussion Leader: Mark Kahn (University of Pennsylvania, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
Timothy Hla (Harvard Medical School, USA)
"HDL and Flow Signaling Intersects S1P Biology at the Endothelium"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden)
"Specialization of Vascular Cells in the CNS"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Brant Isakson (University of Virginia School of Medicine, USA)
"Pannexins as a Key Regulator of Blood Pressure"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Development
Blood vascular growth in bone, intestine, heart and elsewhere will be addressed using mouse and fish genetic models.
Discussion Leader: Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden)
9:00 am - 9:20 am
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Regulation of Organ Morphogenesis by Vascular Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Arya Mani (Yale University, USA)
"PRDM6 Mutations Impair Ductus Arteriosus Remodeling by Inhibiting TGFβ-Dependent Maturation of Vascular Smooth Muscle Cells"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Natasza Kurpios (Cornell University, USA)
"Adventures in Asymmetry: Transcriptional and Cellular Interactions During Gut Vascular Morphogenesis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Kristy Red-Horse (Stanford University, USA)
"Linking Mechandotransduction and Transcriptional Regulation During Artery Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Andrea Rossi (Max Planck Insitute, Germany)
"Regulation of Vegf Signaling by Natural and Synthetic Ligands"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Calvin Kuo (Stanford University, USA)
"Regulation of the Blood Brain Barrier in Development and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Courtney Griffin (Oklahoma Medical Research Foundation, USA)
"How Chromatin-Remodeling Impacts Vascular Development and Integrity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanotransduction in Vascular Development and Disease
How the mechanical forces exerted by blood and lymph shape vascular structures and determine vascular function will be discussed using in vitro systems and both fish and mouse in vivo analyses.
Discussion Leader: Tatiana Byzova (Cleveland Clinic, USA)
7:30 pm - 7:50 pm
Julien Vermot (Institute of Genetics and Molecular and Cellular Biology (IGBMC), France)
"Impact of Mechanical Forces During the Morphogenesis of the Cardiovascular System"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Mary Dickinson (Baylor College of Medicine, USA)
"Live Imaging of Vascular Development with Light Sheet Microscopy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tatiana Petrova ( Lausanne University Hospital / University of Lausanne, Switzerland)
"Biomechanical and Transcriptional Regulation of Postnatal Lymphatic Vasculature"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Martin Schwartz (Yale School of Medicine, USA)
"Endothelial Flow Signaling in Vascular Remodeling and Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Specialized Vascular Beds
The
specialization of vessels in specific organs and their relation to human
disease will be discussed.
Discussion Leader: Luisa Iruela-Arispe (University of California, Los Angeles, USA)
9:00 am - 9:20 am
Kathleen Caron (University of North Carolina at Chapel Hill, USA)
"GPRC Signaling in Vascular Growth and Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Anusha Mishra (Oregon Health and Science University, USA)
"Transcytosis Regulation at the BBB"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Chenghua Gu (Harvard Medical School, USA)
"Interactions Between Nervous and Vascular Systems in the CNS"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Richard Lang (Cincinnati Children's Research Foundation, USA)
"Light-Response Pathways in the Regulation of Vascular Development"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Przemyslaw (Mike) Sapieha (University of Montreal, Canada)
"Premedicine Bridges Hypoxia to Pathological Angiogenesis"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Susan Quaggin (Northwestern University, USA)
"High 'Tek' Solutions for Glaucoma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Anne Eichmann (Yale School of Medicine, USA)
"Guidance of Vascular Patterning"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular
Immunology and Inflammation
The role of
immune and inflammatory responses in vessel function and disease will be
discussed by established and young investigators.
Discussion Leader: Timothy Hla (Harvard Medical School, USA)
7:30 pm - 7:50 pm
Miguel Lopez-Ramirez (University of California, San Diego, USA)
"Regulation of Vascular Cell Adhesion in Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Alan Tang (University of Pennsylvania, USA)
"Unexpected Mechanisms of Cerebral Cavernous Malformation"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Regulatory Networks that Suppress the Pro-Flammatory Status of the Vascular Endothelium"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Magdalena Chrzanowska-Wodnicka (Blood Research Institute, BloodCenter of Wisconsin, USA)
"Regulation of VEGFR2-Mediated Endothelial Responses by Rap1 Under Physiological and Pathological Conditions"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gwendalyn Randolph (Washington University in St. Louis, USA)
"Myeloid Cells in Vascular Function and Inflammation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Vascular Niche in Regeneration
The role of vascular cells in stem cell niches and their participation in organ regeneration will be discussed.
Discussion Leader: Richard Lang (Cincinnati Children's Research Foundation, USA)
9:00 am - 9:20 am
Paul Frenette (Albert Einstein College of Medicine / Montefiore Medical Center, USA)
"Vascular Niches in Health and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Elizabeth Jones (KU Leuven, Belgium)
"Shear Stress, Notch and VE-Cadherin: The Molecular Mechanism of Vascular Fusion"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Eli Keshet (The Hebrew University of Jerusalem, Israel)
"VEGF and Vascular Stem Cell Niches"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Shahin Rafii (Weill Cornell Medicine, USA)
"Angiocrine Contribution of the Vascular Niche to Fibrosis-Free Tissue-Specific Organ Regeneration"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Masanori Nakayama (Max Planck Institute for Heart and Lung Research, Germany)
"VEGF Signaling Independent Endothelial Proliferation Is Regulated by aPKC via FoxO1"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Nancy Speck (University of Pennsylvania School of Medicine, USA)
"Hemogenic Endothelium"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Somanath Shenoy (University of Georgia, USA)
"Mechanisms Regulating Endothelial-to-Mesenchymal Transition (Endmt) and Vascular Remodeling in Acute Lung Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Translation to
Vascular Therapies
Accomplished scientists who have worked in both academia and industry
will discuss the development and testing of new drugs to treat vascular
diseases.
Discussion Leader: Karen Hirschi (Yale School of Medicine, USA)
7:30 pm - 7:55 pm
Gou Young Koh (Institute for Basic Science / Korea Advanced Institute of Science and Technology, South Korea)
"A Novel Tie2 Agonistic Antibody for Vascular Therapies"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Anthony Muslin (Sanofi, USA)
"Novel Therapies for Microvascular Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Shaun Coughlin (University of California, San Francisco, USA)
"Protease-Activated Receptors: Bench to Bedside to Bench"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vascular Metabolism
How vascular cell types serve their own and neighboring cells' metabolic
needs will be discussed.
Discussion Leader: Courtney Griffin (Oklahoma Medical Research Foundation, USA)
9:00 am - 9:20 am
Zoltan Arany (University of Pennsylvania, USA)
"Endothelial Metabolism in and out of the Endothelial Cell"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Mariona Graupera (Bellvitge Biomedical Research Institute (IDIBELL), Spain)
"The p110alpha Isoform of the PI3K Controls Endothelial Cell Rearrangements During Angiogenesis by Stimulating MLC Dephosphorylation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
"Regulation of Endothelial Metabolism by FOXO Transcription Factors"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Stephen Young (University of California, Los Angeles, USA)
"Triglyceride Metabolism Along the Capillary Wall"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Olga Stenina (Cleveland Clinic, USA)
"Regulation of Angiogenesis and Inflammation by miR-467 in Cancer and Insulin Resistance"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Michael Simons (Yale School of Medicine, USA)
"Metabolic Controls of Lymphatic Growth"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Pipsa Saharinen (University of Helsinki / Wihuri Research Institute, Finland)
"Angiopoietin-2 Signaling Switch in Vascular Inflammation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Regulation of Vascular Biology and Disease
The emerging role of epigenetics in vascular biology and disease will be discussed.
Discussion Leader: Zoltan Arany (University of Pennsylvania, USA)
7:30 pm - 7:50 pm
Jason Fish (University Health Network, Canada)
"Regulation of Vascular Inflammation by Noncoding RNAs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Nathan Lawson (University of Massachusetts Medical School, USA)
"Epigenetic Regulation of Endothelial Identity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Paul Fox (Cleveland Clinic, USA)
"Co-Translational Complex Assembly in Macrophages"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Brant Weinstein (National Institute of Child Health and Human Development, NIH, USA)
"Studying Novel Vascular-Associated Cell Populations Using the Zebrafish"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure