Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Vascular Signaling Networks in Development and Disease
Discussion Leader: Susana Cavallero (University of Southern California, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Rong Wang (University of California, San Francisco, USA)
"Arterial-Venous Programming in Development and Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Xuri Li (State Key Laboratory of Ophthalmology, China)
"VEGF-B: The Yin and Yang in Angiogenesis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Ryota Matsuoka (Lerner Research Institute, Cleveland Clinic, USA)
"Neural Progenitor Cell-Mediated Spatiotemporal Control of Spinal Cord Vascularization"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Ingrid Nilsson (Karolinska Institutet, Sweden)
"Energy Substrate Partitioning and Regulation in Endothelial Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Benjamin Hogan (The University of Queensland, Australia)
"The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signalling to Limit Specification of the Lymphatic Lineage"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Vascular Specification and Guidance and Organ-Specific Vasculature
New cellular and molecular mechanisms responsible for vascular guidance and specification will be presented. Specific attributes of blood vessels organization in various organs will be discussed.
Discussion Leaders: Arndt Siekmann (Perelman School of Medicine, University of Pennsylvania, USA) and Elina Kiss (University of Helsinki, Finland)
9:00 am - 9:20 am
Yoshiaki Kubota (Keio University School of Medicine, Japan)
"Neurovascular Communication During CNS Development"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
Anne Eichmann (Yale School of Medicine, USA)
"Guidance of Vascular Barrier Formation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
Hellmut Augustin (Heidelberg University / German Cancer Research Center, Germany)
"Organotypic Differentiation, Regeneration and Angiocrine Functions of the Liver Vasculature"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Hanna Mikkola (University of California, Los Angeles, USA)
"Specification of Hematopoietic Stem Cells from Hemogenic Endothelium"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Selected from Poster Abstracts: Dionna Kasper (Yale University School of Medicine, USA)
"MicroRNA-223 Establishes a Specialized Glycome that Limits Hematopoietic Stem Cell Production from Endothelium"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Selected from Poster Abstracts: Tejasvi Dudiki (Cleveland Clinic Foundation, USA)
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Selected from Poster Abstracts: Lisandra Vila Ellis (University of Texas MD Anderson Cancer Center, USA)
"Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Shashi Kant (University of Massachusetts Medical School, USA)
"Neural JNK3 Regulates Blood Flow Recovery After Hindlimb Ischemia in Mice via an Egr1/Creb1 Axis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Susana Cavallero (University of Southern California, USA), Luisa Iruela-Arispe (University of California, Los Angeles, USA) and Mabruka Alfaidi (LSU Health Sciences Center Shreveport, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inflammatory Networks and Vascular Niche
Discussion Leaders: Martine Clozel (Idorsia Pharmaceuticals Ltd, Switzerland) and Michael McCoy (Cleveland Clinic Foundation, USA)
7:30 pm - 7:50 pm
Luisa Iruela-Arispe (University of California, Los Angeles, USA)
"Inflammation in the Vascular Wall"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
Gwendalyn Randolph (Washington University in St. Louis, USA)
"Dendritic Cells in Vascular and Lymphatic Biology"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Early Vascular Development in Zebrafish and Mouse"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Sara Lovisa (University of Texas MD Anderson Cancer Center, USA)
"The Functional Contribution of Endothelial-to-Mesenchymal Transition to Organ Fibrosis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Selected from Poster Abstracts: Miranda Good (University of Virginia, USA)
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Luiz Henrique Geraldo (Paris Cardiovascular Research Center (PARCC) / INSERM U970 / European Georges Pompidou Hospital, France)
"Dynamic Stroma Reorganization Drives Blood Vessel Dysmorphia During Glioma Progression: A Role for SLIT-ROBO Vascular Guidance Pathway"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology of Vascular and Lymphatic Systems
Discussion Leaders: Karen Hirschi (Yale School of Medicine, USA) and Fadi Pulous (Emory University, USA)
9:00 am - 9:20 am
John Shyy (University of California, San Diego, USA)
"Systems Approach of Flow Regulation of KLF4-ITPR3 Axis in Endothelium"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Brian Coon (Yale University School of Medicine, USA)
"Shear Stress Activation of the Klf2 Pathway"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
Selected from Poster Abstracts: Yun Fang (University of Chicago, USA)
"Human Genetics in Vascular Mechanotransduction and Metabolism"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
Daniel Hammer (University of Pennsylvania, USA)
"Directional Migration of Immune Cells: Chemokine Gradients, Traction Forces and Upstream Control"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland)
"Development and Maintenance of Organ-Specific Lymphatic Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Karina Yaniv (Weizmann Institute of Science, Israel)
"Differentiation of Endothelial Cells and Establishment of Organ-Specific Vessels"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Anthony Orr (LSU Health Sciences Center Shreveport, USA)
"Focal Adhesion EphA2 Signaling Promotes Contractility to Drive Fibrillar Adhesion Formation and Fibronectin Deposition"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Pipsa Saharinen (University of Helsinki, Finland)
"Opposing Functions of Beta1-Integrin in Control of Vascular Integrity and Inflammation-Induced Leakage"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Fan Mo (National Cheng Kung University, Taiwan)
"Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Regulatory Circuits in Vascular Development and Pathologies: Microvasculature and Long Non-Coding RNAs
Discussion Leaders: Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany) and Ekaterina Semina (Moscow State University, Russia)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Timothy Hla (Harvard Medical School, USA)
"Transcriptional and Epigenetic Alterations in Endothelium Post-S1P Receptor Signaling"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Ralf Brandes (Goethe University Frankfurt, Germany)
"Long Non-Coding RNAs in Vasculature"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
Kenneth Walsh (University of Virginia, USA)
"Impact of Clonal Hematopoiesis in Vascular Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
Joseph McCarty (University of Texas MD Anderson Cancer Center, USA)
"Prion-Mediated Activation of Endothelial Cell Signaling Networks in Brain Development and Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Arya Mani (Yale University, USA)
"The Combinatorial Roles of TCF7L2 and GATA6 in Vascular Smooth Muscle Differentiation and Prevention of Intimal Hyperplasia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Recent Advances in Vascular Engineering, Targeting and Imaging
Discussion Leaders: Debabrata Mukhopadhyay (Mayo Clinic College of Medicine and Science, USA) and Axelle Caudrillier (Centre for Cardiovascular Science, University of Edinburgh, United Kingdom)
9:00 am - 9:20 am
Katerina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA)
"Imaging Neurovascular Interactions in Disease"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
James Dahlman (Georgia Institute of Technology / Emory University School of Medicine, USA)
"Targeted Cas9 Nanomedicines and DNA Barcodes"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Selected from Poster Abstracts: Abidemi Junaid (Leiden University, The Netherlands)
"Microengineered Human Blood Vessel for Next Generation Drug Discovery"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
Raghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"Tissue Specific Vascular Endothelium Contribute to Organotropic Metastasis"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Selected from Poster Abstracts: Woo-Ping Ge (University of Texas Southwestern Medical Center, USA)
"Blood Vessel Regression in Adult Mammalian Brains"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Emily Friedrich (University of Illinois at Chicago, USA)
"Endothelial Cell Expressed Piezo1 Regulates Pressure-Induced Lung Vascular Permeability"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Pieter Norden (Northwestern University, USA)
"Foxc1 Regulation of mTOR Signaling During Physiological and Pathological Postnatal Retina Angiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Simone Bersini (Salk Institute for Biological Studies, USA)
"Age-Dependent Modulation of the Human Skin Microvasculature by Microenvironment and Serum"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Vascular Cell Fate and Disease
Discussion Leaders: Ebba Brakenhielm (Normandy University / INSERM U1096, France) and Christopher Schafer (Oklahoma Medical Research Foundation, USA)
7:30 pm - 7:50 pm
Gary Owens (University of Virginia School of Medicine, USA)
"Perivascular Cells Are a Novel Source of Tissue Resident M2 Macrophages Important in Regulation of Vascular Integrity and Tissue Metabolism"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
Michael Simons (Yale University School of Medicine, USA)
"Regulation of Vascular Permeability"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
"Molecular Heterogeneity and Functional Specialization of Vascular Cells"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Selected from Poster Abstracts: Steffen Künzel (Yale University, USA)
"NCK-Dependent Pericyte Migration Promotes Pathological Neovascularization in Ischemic Retinopathy"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Olga Cherepanova (Cleveland Clinic, USA)
"Genetic Inactivation of the Pluripotency Factor OCT4 Within Endothelial Cells Leads to Enhanced Atherosclerosis in Apoe-/- Mice"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Zaki Al-yafeai (LSU Health Sciences Center Shreveport, USA)
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metabolic Control of Vasculature and Blood Vessels in Metabolic Diseases
Discussion Leaders: Zoltan Arany (University of Pennsylvania, USA) and Gamze Bulut (University of Virginia, USA)
9:00 am - 9:20 am
William Sessa (Yale University School of Medicine, USA)
"Endocrine Function of Endothelium in Metabolism and Inflammation"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
Selected from Poster Abstracts: Anthony Angueira (Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, USA)
"Control of Perivascular Adipose Tissue Development and Thermogenesis by Early B Cell Factor 2"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
Calvin Kuo (Stanford University, USA)
"Molecular and Therapeutic Aspects of Blood-Brain Barrier Regulation"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Selected from Poster Abstracts: Boa Kim (University of Pennsylvania, USA)
"Dual Roles of PKM2 in Endothelial Cell Proliferation and Vascular Permeability"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Mukesh Jain (Case Western Reserve University, USA)
"Myeloid Cells in Vasculature"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Ulf Eriksson (Karolinska Institutet, Sweden)
"Reducing VEGF-B Signalling Ameliorates Hepatic Steatosis and Prevents Development of Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Selected from Poster Abstracts: Siobhan Craige (Virginia Tech, USA)
"Exercise Promotes White Adipose Tissue Angiogenesis and Protects from Diet-Induced Metabolic Defects"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Selected from Poster Abstracts: Naoki Sawada (Rutgers New Jersey Medical School, USA)
"PGC-1a/ARHGAP6 Axis Mediates Diabetic Vascular Dysfunction Through Diminution of Endothelial Glycolytic Flux"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Moritz Reiterer (University of Cambridge, United Kingdom)
"Organ-Specific Heterogeneity in Endothelial Cell Hypoxia Response"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Vascular Inflammation and Aging
Discussion Leaders: William Sessa (Yale University School of Medicine, USA) and Tejasvi Dudiki (Cleveland Clinic Foundation, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
Michael Karin (University of California, San Diego, USA)
"Mitochondrial Control of Inflammation: Positive and Negative Control of the NLRP3 Inflammasome"
8:00 pm - 8:15 pm
Discussion
8:15 pm - 8:20 pm
Introduction by Discussion Leader
8:20 pm - 8:45 pm
Denisa Wagner (Harvard Medical School, USA)
"PAD4: The Nuclear Button of Inflammation and Aging"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure