Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Vascular Heterogeneity and Development
7:40 pm - 8:00 pm
"Endothelial Heterogeneity in Development and Tumour Angiogenesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Macrophage-Endothelial Cross Talk in Tissue Vascularization"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Cell Fate Specification During Blood Vessel Development and Organogenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"A Transcriptional Regulatory Logic for Pericyte Heterogeneity"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology and Bioengineering
9:00 am - 9:20 am
"Endoglin Signaling Controls Endothelial Cell Shape Differences Between Arteries and Veins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Flow-Activated Pathways Reversing Endothelial Cell Dysfunction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Contribution of Mechanical Forces From Blood Flow in Neurovascular Aneurysmal Malformations"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"High Fluid Shear Stress Induces Outward Remodeling Through a KLF2-BMPER Pathway"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Moonlighting Mechanosensor"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Vascular Mechanobiology: Learning from Engineered Blood Vessels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Protocadherin Gamma Flow Signaling as Therapeutic Target in Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis in Chronic Lung Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular Complications of Pregnancy
7:30 pm - 7:50 pm
"Vascular Mechanisms for Preeclampsia and Related Disorders"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lymphatic Mimicry at the Maternal-Fetal Interface"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Leveraging Nature’s Success: Lessons from Modifiers of Marfan Syndrome and Related Aneurysm Conditions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"New Insights into Placental Vascular Growth and Function"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:20 am
"New Opportunities for Anti-Angiogenesis in Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Skeletal Muscle Endothelial Dysfunction in Cancer Cachexia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Obesogenic Diet Promotes Endothelial-to-Mesenchymal Transition in Adipose Tissue"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Endothelial Metabolism in Tumor Immunity and Resistance to Immunotherapy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Long-range Endothelial Cell Junction Regulation Via Nuclear SUN1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Oxidative Stress and Innate Immunity in Vascular Pathologies and Aging"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"A Human Vascular Differentiation Roadmap Reveals Unexpected Venous Origins and Target Cells of Deadly Viruses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Chylomicrons, Endothelial Cells, and the Atherogenicity of Postprandial Lipemia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Endothelial Metabolism in the Muscle"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Endothelial Lipids and Blood Pressure"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Fatty Acid-binding Proteins Promote Endothelial Glycolysis and Arterial Programming"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Thrombolytic tPA-induced Intracerebral Hemorrhage in Ischemic Stroke is Mediated by Increased Adipose Tissue Lipolysis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Disease in the Cardiovascular Tree
9:00 am - 9:20 am
"Metabolic Fitness and the Competitive Vascular Zonation of Endothelial Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"An Enhancer-based Approach to Studying Vessel Development"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Endothelial Cell Mitochondria and Sex Differences in Atherosclerosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"High-throughput CRISPR Screening Links CAD Loci to Endothelial Cell Programs and Causal Pathways"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Cardiooncology through the Lens of Vascular Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Leveraging Human Genetics to Develop Drugs that Address Residual Risk of CV Events"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Global Inhibition of Myeloperoxidase Improves Survival in a Novel Mouse Model of Coronary Atherosclerosis, Spontaneous Myocardial Infarction and Stroke"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"PRDM6 Regulates the Embryonic Differentiation of Renin-producing Cells into Vascular Smooth Muscle Cells and its Altered Function Causes Hypertension"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular Metabolism and Pulmonary Disease
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Multi-dimensional -omics Analyses Reveal Novel Metabolic Mechanisms of Endothelial Dysfunction in Pulmonary Hypertension"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Dysfunctional Angiogenesis in Pulmonary Arterial Hypertension: The Role of Wnt Signaling Pathways"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Alternative Polyadenylation Leads to 3’UTR Shortening of Prostaglandin E3 Receptor and Increased RUNX1 Expression in Pulmonary Arterial Hypertension"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Intermediate States in Pulmonary Fibrosis Are Associated With Metabolic Shifts in Cellular Reprogramming"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Vessels and Neurovascular Disease
9:00 am - 9:20 am
"The Intra and Intercellular Communication at the Blood-Brain Barrier"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Anatomy of Blood Vessels and Vessel-associated Structures"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Role of Neuroendothelial Cells in Organ Blood Flow Regulation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Mesenchymal mTOR Activation Contributes to Pulmonary Vascular Remodeling Through Dysregulation of Vascular Endothelial Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Vascular Endothelium in Development and Beyond"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Vascular Dysfunction in the Kidney"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"RNA Surveillance by ADAR1 is Required for Vascular Endothelial Resilience"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"m6A RNA Methylation is Integral for the Maintenance of Vascular Endothelial Cell Resilience"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Undoing Loss of Microvascular Homeostasis Promotes Healthy Aging"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Age of the Bone Marrow Dictates Clonality of Smooth Muscle-derived Cells in the Atherosclerotic Plaque"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cerebromicrovascular Senescence in Aging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Endothelial Diversity: Cell Type-specific Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure