Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Vascular Heterogeneity and Development
Discussion Leader: Anne Eichmann (Yale School of Medicine, United States)
7:40 pm - 8:00 pm
Holger Gerhardt (Max Delbrück Center for Molecular Medicine, Germany)
"Endothelial Heterogeneity in Development and Tumour Angiogenesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Christiana Ruhrberg (University College London, United Kingdom)
"Macrophage-Endothelial Cross Talk in Tissue Vascularization"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Ondine Cleaver (University of Texas Southwestern Medical Center, United States)
"Cell Fate Specification During Blood Vessel Development and Organogenesis"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Nathan Lawson (University of Massachusetts Chan Medical School, United States)
"A Transcriptional Regulatory Logic for Pericyte Heterogeneity"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology and Bioengineering
Discussion Leader: Martin Schwartz (Yale School of Medicine, United States)
9:00 am - 9:20 am
Arndt Siekmann (Perelman School of Medicine, University of Pennsylvania, United States)
"Endoglin Signaling Controls Endothelial Cell Shape Differences Between Arteries and Veins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Guillermo Garcia-Cardena (Harvard Medical School, United States)
"Flow-Activated Pathways Reversing Endothelial Cell Dysfunction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Nicolas BAEYENS (Université Libre de Bruxelles, Belgium)
"Contribution of Mechanical Forces From Blood Flow in Neurovascular Aneurysmal Malformations"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Hanqiang Deng (Yale University School of Medicine, United States)
"High Fluid Shear Stress Induces Outward Remodeling Through a KLF2-BMPER Pathway"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ellie Tzima (University of Oxford, United Kingdom)
"The Moonlighting Mechanosensor"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Christopher Chen (Boston University , United States)
"Vascular Mechanobiology: Learning from Engineered Blood Vessels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Divyesh Joshi (Yale University, United States)
"Protocadherin Gamma Flow Signaling as Therapeutic Target in Atherosclerosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Susan Majka (University of Colorado-National Jewish Health, United States)
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis in Chronic Lung Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Luisa Iruela-Arispe (Northwestern University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular Complications of Pregnancy
Discussion Leader: Karen Hirschi (University of Virginia School of Medicine, United States)
7:30 pm - 7:50 pm
Ananth Karumanchi (Cedars-Sinai Medical Center, United States)
"Vascular Mechanisms for Preeclampsia and Related Disorders"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Kathleen Caron (University of North Carolina at Chapel Hill, United States)
"Lymphatic Mimicry at the Maternal-Fetal Interface"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hal Dietz (Johns Hopkins/HHMI, United States)
"Leveraging Nature’s Success: Lessons from Modifiers of Marfan Syndrome and Related Aneurysm Conditions"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Mark Kahn (University of Pennsylvania, United States)
"New Insights into Placental Vascular Growth and Function"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Inflammation and Cancer
Discussion Leader: Luisa Iruela-Arispe (Northwestern University, United States)
9:00 am - 9:20 am
Laura Benjamin (OncXerna, United States)
"New Opportunities for Anti-Angiogenesis in Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jalees Rehman (University of Illinois at Chicago, United States)
"Skeletal Muscle Endothelial Dysfunction in Cancer Cachexia"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Nicholas Chavkin (University of Virginia, United States)
"Obesogenic Diet Promotes Endothelial-to-Mesenchymal Transition in Adipose Tissue"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Yi Fan (University of Pennsylvania, United States)
"Endothelial Metabolism in Tumor Immunity and Resistance to Immunotherapy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Victoria Bautch (University of North Carolina at Chapel Hill, United States)
"Long-range Endothelial Cell Junction Regulation Via Nuclear SUN1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Tatiana Byzova (The Cleveland Clinic, United States)
"Oxidative Stress and Innate Immunity in Vascular Pathologies and Aging"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kyle Loh (Stanford University School of Medicine, United States)
"A Human Vascular Differentiation Roadmap Reveals Unexpected Venous Origins and Target Cells of Deadly Viruses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipids and Vasculature
Discussion Leader: Timothy Hla (Boston Children's Hospital and Harvard Medical School, United States)
7:30 pm - 7:50 pm
Ira Goldberg (New York University, United States)
"Chylomicrons, Endothelial Cells, and the Atherogenicity of Postprandial Lipemia"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Katrien De Bock (ETH Zurich, Switzerland)
"Endothelial Metabolism in the Muscle"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Boa Kim (University of North Carolina at Chapel Hill, United States)
"Endothelial Lipids and Blood Pressure"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Zhiyu Dai (University of Arizona, United States)
"Fatty Acid-binding Proteins Promote Endothelial Glycolysis and Arterial Programming"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Ulf Eriksson (Karolinska Institutet, Sweden)
"Thrombolytic tPA-induced Intracerebral Hemorrhage in Ischemic Stroke is Mediated by Increased Adipose Tissue Lipolysis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Disease in the Cardiovascular Tree
Discussion Leader: Kenneth Walsh (University of Virginia, United States)
9:00 am - 9:20 am
Rui Benedito (Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain)
"Metabolic Fitness and the Competitive Vascular Zonation of Endothelial Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sarah De Val (University of Oxford, United Kingdom)
"An Enhancer-based Approach to Studying Vessel Development"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Olga Cherepanova (Cleveland Clinic, United States)
"Endothelial Cell Mitochondria and Sex Differences in Atherosclerosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Rajat Gupta (Brigham and Women's Hospital/Harvard Medical School, United States)
"High-throughput CRISPR Screening Links CAD Loci to Endothelial Cell Programs and Causal Pathways"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Iris Jaffe (Tufts Medical Center, United States)
"Cardiooncology through the Lens of Vascular Biology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Saptarsi Haldar (Amgen, United States)
"Leveraging Human Genetics to Develop Drugs that Address Residual Risk of CV Events"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
SOHEL SHAMSUZZAMAN (University of Virginia School of Medicine, United States)
"Global Inhibition of Myeloperoxidase Improves Survival in a Novel Mouse Model of Coronary Atherosclerosis, Spontaneous Myocardial Infarction and Stroke"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Trojan Rugira (Yale University, United States)
"PRDM6 Regulates the Embryonic Differentiation of Renin-producing Cells into Vascular Smooth Muscle Cells and its Altered Function Causes Hypertension"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular Metabolism and Pulmonary Disease
Discussion Leader: Mariona Graupera (Josep Carreras Leukaemia Research Institute, Spain)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Stephen Chan (University of Pittsburgh School of Medicine, United States)
"Multi-dimensional -omics Analyses Reveal Novel Metabolic Mechanisms of Endothelial Dysfunction in Pulmonary Hypertension"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Vinicio de Jesus Perez (Stanford University, United States)
"Dysfunctional Angiogenesis in Pulmonary Arterial Hypertension: The Role of Wnt Signaling Pathways"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Harry Karmouty Quintana (University of Texas Health Science Center at Houston, United States)
"Alternative Polyadenylation Leads to 3’UTR Shortening of Prostaglandin E3 Receptor and Increased RUNX1 Expression in Pulmonary Arterial Hypertension"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Catherine Kim (Yale University, United States)
"Intermediate States in Pulmonary Fibrosis Are Associated With Metabolic Shifts in Cellular Reprogramming"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Vessels and Neurovascular Disease
Discussion Leader: Mukesh Jain (Warren Alpert Medical School of Brown University, United States)
9:00 am - 9:20 am
Chenghua Gu (Harvard Medical School, United States)
"The Intra and Intercellular Communication at the Blood-Brain Barrier"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Christer Betsholtz (Uppsala University, Sweden)
"Molecular Anatomy of Blood Vessels and Vessel-associated Structures"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Georgina Gyarmati (University of Southern California, United States)
"The Role of Neuroendothelial Cells in Organ Blood Flow Regulation"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Susan Lin (University of Pennsylvania, United States)
"Mesenchymal mTOR Activation Contributes to Pulmonary Vascular Remodeling Through Dysregulation of Vascular Endothelial Cells"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stefania Nicoli (Yale University, United States)
"The Vascular Endothelium in Development and Beyond"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Susan Quaggin (Northwestern University, United States)
"Vascular Dysfunction in the Kidney"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Konstantinos Stellos (University of Heidelberg, Germany)
"RNA Surveillance by ADAR1 is Required for Vascular Endothelial Resilience"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Simon Tual-Chalot (Newcastle University, United Kingdom)
"m6A RNA Methylation is Integral for the Maintenance of Vascular Endothelial Cell Resilience"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Vascular Aging
Discussion Leader: Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany)
7:30 pm - 7:50 pm
Myriam Grunewald (Faculty of Medicine, The Hebrew University, Israel)
"Undoing Loss of Microvascular Homeostasis Promotes Healthy Aging"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Inamul Kabir (Yale University, United States)
"Age of the Bone Marrow Dictates Clonality of Smooth Muscle-derived Cells in the Atherosclerotic Plaque"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Zoltan Ungvari (University of Oklahoma Health Sciences Center, United States)
"Cerebromicrovascular Senescence in Aging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Napoleone Ferrara (University of California, San Diego, United States)
"Endothelial Diversity: Cell Type-specific Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure