Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Mechanisms and Mechanics in Vascular Patterning
Discussion Leader: Alexandre Dubrac (Yale University, USA)
3:45 pm - 4:20 pm
Holger Gerhardt (VIB Center for Cancer Biology, KU Leuven, Germany)
"Mechanisms and Mechanics in Vascular Patterning"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
From Sprouts to Established Vessels: Mechanisms
of Endothelial Function
Discussion Leaders: Christer Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden) and Mafalda Lopes Da Silva (MRC Laboratory for Molecular Cell Biology, University College London, United Kingdom)
7:30 pm - 7:45 pm
Dionna Kasper (Yale University School of Medicine, USA)
"Mutagenesis of microRNA Genes Uncovers Trait Variance as a Unique Vascular Phenotype that Confers Stress Sensitization"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Jonathan Nelson (Oregon Health and Science University, USA)
"Hypertension-Dependent Reprogramming of the Endothelial Transcriptome"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Takao Hikita (Max-Planck-Institute for Heart and Lung Research, Germany)
"Antagonism Between PAR-3/aPKC and aPKC/GSK3beta Complexes Controls Endothelial Polarization in the Planar Axis Toward Flow"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Marchand Marion (College de France, France)
"Extracellular Matrix Scaffolding Dictates Endothelial Mechanotransduction and 3D Vascular Morphogenesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
David Wu (University of Chicago, USA)
"Mechanical Regulation of Endothelial Cell Metabolism by HIF-1alpha"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Pengchun Yu (Yale University School of Medicine, USA)
"FGF-Dependent Metabolic Control of Vascular Development"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Endothelial Partners in Vessel Development and Homeostasis / Specialization of Unique Vascular Beds
Discussion Leaders: Timothy Hla (Harvard Medical School, USA), Kristy Red-Horse (Stanford University, USA), Alaina Reagan (University of Oklahoma Health Sciences Center, USA) and Yoshi Odaka (Cincinnati Children's Hospital Medical Center, USA)
9:00 am - 9:15 am
Alan Tang (University of Pennsylvania, USA)
"Unexpected Mechanisms of Cerebral Cavernous Malformation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Jordan Darden (Virginia Tech, USA)
"Loss of Flt-1 Impacts Pericyte Recruitment and Investment During Early Development"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Tejasvi Dudiki (Cleveland Clinic Foundation, USA)
"Kindlin 3 in Microglia Controls Retinal Vascularization"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Aparna Mahadevan (Cornell University, USA)
"The Left-Right PITX2 Pathway Coordinates Gut Morphogenesis with Organ-Specific Arterial and Lymphatic Development"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Tine Wyseure (The Scripps Research Institute, USA)
"Defective TAFI Activation in Hemophilia Exacerbates Vascular Remodeling in Hemophilic Arthropathy"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Miguel Lopez-Ramirez (University of California, San Diego, USA)
"Thrombospondin1 (TSP1) Replacement Prevents Cerebral Cavernous Malformations"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Panel
A panel of established professionals from academia and industry.
Discussion Leaders: Jennifer Fang (Yale University, USA) and Irinna Papangeli (Yale University, USA)
1:30 pm - 2:30 pm
Panel Discussion
So You Want to Be a Vascular Biologist
Kristy Red-Horse (Stanford University, USA)
Holger Gerhardt (VIB Center for Cancer Biology, KU Leuven, Germany)
Sunday Oladipupo (Lilly Research Laboratories, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes