Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Blood Vessel Growth, Remodeling and Specification in the Healthy and Diseased Vasculature
The blood vasculature is characteristically organized, and dysregulation of the signals that govern vessel patterning have profound implications on vascular health and function. This session highlights junior investigators whose work focuses on vessel growth regulation in the context of both cardiovascular health and disease.
Discussion Leader: Miguel Lopez-Ramirez (University of California, San Diego, USA)
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
Nele Warmke (Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom)
"Pericyte Insulin Signalling Modulates Sprouting Angiogenesis and Whole Body Metabolism"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Tejasvi Dudiki (Cleveland Clinic Foundation, USA)
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Talkative Vasculature: Cell Signaling in Blood Vessels and Beyond
The vasculature is a nexus for cell signaling between blood vessel cells and other cell types. This session opens with our first keynote speaker (Dr. Kenneth Walsh, University of Virginia), followed by selected talks by junior investigators whose work focuses on endothelial cell interactions with non-vascular cell types and extracellular matrix.
Discussion Leaders: Luisa Iruela-Arispe (University of California, Los Angeles, USA) and Tejasvi Dudiki (Cleveland Clinic Foundation, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
Kenneth Walsh (University of Virginia, USA)
"Killer Clones: Somatic Mutations, Clonal Hematopoiesis and Cardiovascular Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Miranda Good (University of Virginia, USA)
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Robert Pulido (University of California, San Diego, USA)
"Molecular Plasticity of the Cerebral Vasculature in Response to Neural Activity"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Kaori Yamada (University of Illinois at Chicago, USA)
"Regulation of Angiogenesis via Polarized Trafficking of VEGFR2 to Plasmalemma Mediated by the Molecular Motor KIF13B"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Zaki Al-yafeai (LSU Health Sciences Center Shreveport, USA)
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Endothelial Interactions: Mechanisms and Implications of Cell Signaling and Communication in the Vasculature
Endothelial cells are regulated by a vast array of converging signaling mechanisms that integrate to dictate endothelial cell function. This session is opened by our second keynote speaker (Dr. Dider Stainier, Max Planck Institute) followed by selected talks by junior investigators whose work offer novel insights into cell signaling events in the vasculature.
Discussion Leaders: Ralf Brandes (Goethe University Frankfurt, Germany) and Miranda Good (University of Virginia, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
Didier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Early Vascular Development in Zebrafish and Mouse"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Anand Narayanan (Yale University School of Medicine, USA)
"Dyrk1b Is a Novel Regulator of Skeletal Muscle Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Uchenna Emechebe (Oregon Health and Science University, USA)
"A Multi-Organ Analysis of Endothelial Transcriptional Remodeling Across Lifespan"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Fadi Pulous (Emory University, USA)
"Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Axelle Caudrillier (Centre for Cardiovascular Science, University of Edinburgh, United Kingdom)
"Single-Cell RNA-Seq Analysis Unveils a Hypersensitive Endothelial Population Poised for Endothelial to Mesenchymal Transition"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Breakout Sessions
Attendees will have the opportunity to select two 20-minute breakout sessions each focused on a broad range of professional development topics, including: career development in academia, career development in industry, and launching a biomedical startup. Each breakout session will be led by a senior scientist and/or industry professional with specific expertise on their topic. The format of this event will enable each attendee to receive one-on-one mentorship and interaction with two established researchers on a topic related specifically to that attendee's individualized career goals.
Discussion Leaders: Jennifer Fang (University of California, Irvine, USA), Karen Hirschi (Yale School of Medicine, USA), Christopher Hughes (University of California, Irvine, USA) and Abdul Sheikh (Pfizer, USA)
1:30 pm - 1:45 pm
Introduction by Discussion Leader
1:45 pm - 2:25 pm
Breakout Sessions
2:25 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes