Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Blood Vessel Growth, Remodeling and Specification in the Healthy and Diseased Vasculature
The blood vasculature is characteristically organized, and dysregulation of the signals that govern vessel patterning have profound implications on vascular health and function. This session highlights junior investigators whose work focuses on vessel growth regulation in the context of both cardiovascular health and disease.
3:45 pm - 3:50 pm
Opening Remarks
3:50 pm - 4:05 pm
"Pericyte Insulin Signalling Modulates Sprouting Angiogenesis and Whole Body Metabolism"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Mechanosensory Function of Kindlin3 in Microglia Is Crucial for Retinal Vascular Patterning"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Talkative Vasculature: Cell Signaling in Blood Vessels and Beyond
The vasculature is a nexus for cell signaling between blood vessel cells and other cell types. This session opens with our first keynote speaker (Dr. Kenneth Walsh, University of Virginia), followed by selected talks by junior investigators whose work focuses on endothelial cell interactions with non-vascular cell types and extracellular matrix.
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Killer Clones: Somatic Mutations, Clonal Hematopoiesis and Cardiovascular Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Endothelial Pannexin1-Purinergic Signaling Axis Is a Key Regulator of the Cerebral Ischemic Response"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Molecular Plasticity of the Cerebral Vasculature in Response to Neural Activity"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Regulation of Angiogenesis via Polarized Trafficking of VEGFR2 to Plasmalemma Mediated by the Molecular Motor KIF13B"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Integrin-Specific Signaling Drives ER Stress to Promote JNK Signaling and Atherogenic Endothelial Activation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Endothelial Interactions: Mechanisms and Implications of Cell Signaling and Communication in the Vasculature
Endothelial cells are regulated by a vast array of converging signaling mechanisms that integrate to dictate endothelial cell function. This session is opened by our second keynote speaker (Dr. Dider Stainier, Max Planck Institute) followed by selected talks by junior investigators whose work offer novel insights into cell signaling events in the vasculature.
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Early Vascular Development in Zebrafish and Mouse"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Dyrk1b Is a Novel Regulator of Skeletal Muscle Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"A Multi-Organ Analysis of Endothelial Transcriptional Remodeling Across Lifespan"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Single-Cell RNA-Seq Analysis Unveils a Hypersensitive Endothelial Population Poised for Endothelial to Mesenchymal Transition"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Development Breakout Sessions
Attendees will have the opportunity to select two 20-minute breakout sessions each focused on a broad range of professional development topics, including: career development in academia, career development in industry, and launching a biomedical startup. Each breakout session will be led by a senior scientist and/or industry professional with specific expertise on their topic. The format of this event will enable each attendee to receive one-on-one mentorship and interaction with two established researchers on a topic related specifically to that attendee's individualized career goals.
1:30 pm - 1:45 pm
Introduction by Discussion Leader
1:45 pm - 2:25 pm
Breakout Sessions
2:25 pm - 2:30 pm
Closing Remarks
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes