| Sunday, June 24 |
| 6:00 | Dinner |
| 7:15 | Introduction/ Welcome -
Organizer - Karla Kirkegaard (Stanford University)
Co-Organizer - Lynn Enquist (Princeton University) |
| 7:25 | Keynote speaker - CHARLIE RICE (Rockefeller University)
"Hepatitis C: progress on a persistent troublemaker" |
| 8:10 | discussion |
| PM | Session I: Pathogenesis |
| Leader: PAULA TRAKTMAN (Medical College of Wisconsin) |
| 8:20 | Introduction to session |
| 8:25 | MICHAEL OLDSTONE (Scripps Institute)
"Anatomy of virus induced suppression of the immune system" |
| 8:50 | discussion |
| 9:00 | DON GANEM (University of California, San Francisco)
"Evasion of host cell defense by human HHV8" |
| 9:25 | discussion |
| 9:30 | RECEPTION |
| Monday, June 25 |
| AM | Session II: Receptors, membrane fusion, entry |
| Discussion Leader: JACK ROSE (Yale University) |
| 8:30 | GROUP PHOTOGRAPH |
| 9:00 | Introduction to session |
| 9:05 | PAT SPEAR (Northwestern University)
"Multiple receptor-ligand interactions for herpes simplex virus entry" |
| 9:30 | discussion |
| 9:40 | BOB LAMB (Northwestern University)
"Understanding paramyxovirus-mediated membrane fusion" |
| 10:05 | discussion |
| 10:15 | Coffee break |
| 10:45 | JOHN YOUNG (Harvard University)
"Characterizing a novel pH-dependent viral entry pathway involving receptor-priming of a retroviral glycoprotein" |
| 11:10 | discussion |
| 11:20 | DENNIS BAMFORD (University of Helsinki)
"A dsRNA virus polymerase complex: from purified protein and RNA constituents to infectious particles" |
| 11:45 | discussion |
| 11:55 | YUSUKE YANAGI (Kyushu University)
"SLAM, the cellular receptor for measles virus" |
| 12:05 | discussion |
| 12:10 | ROBERTO CATTANEO (Mayo Clinic)
"Novel replicating viral vectors entering cells through targeted receptors" |
| 12:20 | discussion |
| 12:30 | lunch |
| 1:30 - 6pm | Free Time |
| Dinner |
| PM | Session III. Synthesis, processing and trafficking of viral proteins |
| Leader: ROZ SANDRI-GOLDIN (University of California, Irvine) |
| 7:30 | Introduction to session |
| 7:35 | ROBERT SCHNEIDER (New York University)
"Adenovirus translational control: Remodeled cap-initiation complexes and jumping ribosomes" |
| 8:00 | discussion |
| 8:10 | ELLEN FANNING (Vanderbilt University)
"Musical chairs during SV40 DNA replication: New insights into the players" |
| 8:35 | discussion |
| 8:45 | PETER PALESE (Mt. Sinai School of Medicine)
"Nucleo-cytoplasmic Trafficking of Influenza Virus RNPs" |
| 9:10 | discussion |
| 9:20 | BRIAN WARD (National Institutes of Health)
"Visualization of intracellular movement of vaccinia virus virions
containing a green fluorescent protein - B5R membrane protein chimera" |
| 9:30 | ELI LILLY RECEPTION and POSTER SESSION #1 |
| Tuesday, June 26 |
| AM | Session IV: Viral replication and gene expression |
| Leader: CRAIG GIBBS (Gilead Sciences) |
| 9:00 | Introduction to session |
| 9:05 | PETER TATTERSALL (Yale University)
"A novel player in the initiation of rolling hairpin DNA replication" |
| 9:30 | discussion |
| 9:40 | HU JIANMING (Boston University)
"Reconstitution of a hepadnavirus protein priming complex" |
| 9:50 | discussion |
| 9:55 | ANIKO PAUL (State University of New York, Stony Brook)
"Biochemical and genetic studies of the protein-priming reaction catalyzed
by the RNA polymerases of poliovirus and human rhinovirus 2" |
| 10:05 | discussion |
| 10:10 | Coffee break |
| 10:40 | SUE MOYER (University of Florida)
"Functions of the L subunit of the Sendai virus RNA polymerase |
| 11:15 | discussion |
| 11:25 | TOM SHENK (Princeton University)
"Human cytomegalovirus: immediate early and earlier events in the
virus-host cell interaction" |
| 11:50 | discussion |
| 12:00 | SHANE CROTTY (University of California, San Francisco)
"Viral escape from a drug with a cellular protein target" |
| 12:10 | discussion |
| 12:15 | YIZHI TAO (Harvard University)
"RNA synthesis in a cage: structural studies on reovirus polymerase l3" |
| 12:25 | discussion |
| 12:30 | lunch |
| 1:30 - 6:00 | Free time |
| Dinner |
| PM | Session V. Interaction of viruses and the immune system |
| Leader: MICHAEL KATZE (University of Washington) |
| 7:30 | Introduction to session |
| 7:35 | FRANK CHISARI (Scripps Institute)
"Control of HBV replication by inflammatory cytokine" |
| 8:00 | discussion |
| 8:10 | SKIP VIRGIN (Washington University)
"Host and viral genes the determine gammaherpesvirus pathogenesis" |
| 8:35 | discussion |
| 8:45 | RAY WELSH (University of Massachusetts)
"Evolution of CD8 T cell responses and their role in heterologous immunity" |
| 9:10 | discussion |
| 9:20 | SALLY HUBER (University of Vermont)
"Immunopathogenic mechanisms of injury during coxsackievirus B3 infection" |
| 9:30 | RECEPTION and POSTER SESSION #2 |
| Wednesday, June 27 |
| AM | Session VI: Host defense/virus offense |
| Leader: NANCY REICH (State University of New York, Stony Brook) |
| 9:00 | Introduction to session |
| 9:05 | ED MOCARSKI (Stanford University)
"The best offense is not just a good defense: Cytomegalovirus-encoded chemokine attracts host leukocytes for dissemination." |
| 9:30 | discussion |
| 9:40 | GEOFF SMITH (University of Oxford)
"How poxviruses interfere with the host response to infection" |
| 10:05 | discussion |
| 10:15 | Coffee break |
| 10:45 | BETH LEVINE (Columbia University)
"Autophagy genes as novel antiviral effectors" |
| 11:10 | discussion |
| 11:20 | KEN TYLER (University of Colorado Health Sciences Center)
""Mechanisms of virus-induced apoptosis in vitro and in
vivo: lessons from the reovirus system." |
| 11:45 | discussion |
| 11:55 | RICHARD MOYER (University of Florida)
"Analysis of intragenic and extragenic suppressors of a host range mutation
in the rabbitpox virus serpin SPI-1" |
| 12:05 | discussion |
| 12:10 | SUSAN PARRISH (Carnegie Institute of Washington)
"Exploring the molecular mechanism of RNA-mediated interference (RNAi)" |
| 12:20 | discussion |
| 12:30 | lunch |
| 1:30 - 6pm | Free Time |
| 6pm | Dinner |
| PM | Session VII: Virus evolution |
| Leader RON SWANSTROM (University of North Carolina) |
| 7:30 | Introduction to session |
| 7:35 | LUIS VILLARREAL (University of California, Irvine)
"How viral persistence affects virus and host evolution" |
| 8:00 | Discussion |
| 8:10 | CRAIG CAMERON (Pennsylvania State University)
"Quasispecies, Error Catastrophe and the Antiviral Activity of Ribavirin " |
| 8:35 | Discussion |
| 8:45 | ALICE TELESNITSKY (University of Michigan)
"Reverse transcriptase template switching and retroviral genetic recombination" |
| 9:10 | Discussion |
| 9:20 | NAY-WEI SOONG (Maxygen, Inc.)
"Directed evolution of viruses using molecular breeding" |
| 9:30 | GILEAD PHARMACEUTICALS RECEPTION and POSTER SESSION #3 |
| Thursday, June 28 |
| AM | Session VIII: Structure and assembly of viral proteins and nucleic acids |
| Leader: JACK JOHNSON (Scripps Institute) |
| 9:00 | Introduction to session |
| 9:05 | MAX NIBERT (University of Wisconsin)
"Assembling the Reovirus Particle, in More Ways Than One" |
| 9:30 | discussion |
| 9:40 | ANETTE SCHNEEMAN (Scripps Institute)
"RNA-protein interactions involved in nodaviral genome recognition and assembly" |
| 10:05 | discussion |
| 10:15 | Coffee break |
| 10:45 | JODY PUGLISI (Stanford University)
"Determination of RNA structure in the HCV IRES by NMR" |
| 11:10 | discussion |
| 11:20 | JIM HOGLE (Harvard University)
"The structure and mechanism of the herpes simplex protein UL42, an unusual monomeric processivity factor and potential target for antivirals" |
| 11:45 | discussion |
| 11:55 | JAY BROWN (University of Virginia)
"Packaging DNA into the herpes simplex virus capsid" |
| 12:05 | discussion |
| 12:10 | SUCHETANA MUKHOPADHYAY (Purdue University)
"Location of carbohydrate sites on alphavirus glycoproteins shows that E1
forms an icosahedral scaffold" |
| 12:20 | discussion |
| 12:30 | lunch |
| PM | Session IX. Exploiting host functions |
| Leader: BERT SEMLER (University of California, Irvine) |
| 7:30 | Introduction to session |
| 7:35 | MATTHIAS DOBBELSTEIN (University of Marburg)
"Adenovirus as a tool in cancer research and therapy" |
| 8:00 | discussion |
| 8:10 | JAMES CARRINGTON (Oregon State University)
"Virus-Host Interactions and RNA Silencing in Plants" |
| 8:35 | discussion |
| 8:45 | BERNARD ROIZMAN (University of Chicago)
"Subversion and other diversions of cellular proteins by herpes
simplex virus" |
| 9:10 | discussion |
| 9:20 | ROZANNE SANDRI-GOLDIN (University of California, Irvine)
"The mechanism of splicing inhibition by HSV-1 ICP27" |
| 9:30 | RECEPTION and POSTER SESSION #4 |
| |
