| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Welcome Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | ENTRY AND RECEPTORS |
| Discussion Leaders: Jeff Bergelson (University of Pennsylvania) & Bernie Moss (NIH/NIAID) |
| 7:35 pm - 7:55 pm | Felix Rey (Institut Pasteur)
"Viral membrane fusion proteins: how many different structural classes?" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Terry Dermody (Vanderbilt University Medical Center)
"Reovirus receptors and pathogenesis" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Katya Heldwein (Tufts University)
"Herpesvirus glycoprotein B - what structure can tell us about function" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Roselyn Eisenberg (University of Pennsylvania)
"Herpes simplex virus entry: a process of complexes and complexities" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | RNA VIRUS TRANSLATION, TRANSCRIPTION AND REPLICATION |
| Discussion Leaders: Ralf Bartenschlager (University of Heidelberg) & Doug Lyles (Wake Forest University) |
| 9:00 am - 9:20 am | Andrea Gamarnik (Fundacion Intituto Leloir, Buenos Aires)
"Mechanism of dengue virus RNA synthesis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ann Palmenberg (University of Wisconsin, Madison)
"Cardiovirus leader protein triggers phosphorylation of nucleocytoplasmic transport machinery and inhibits protein/RNA binding" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Didier Poncet (CNRS Gif-sur-Yvette)
"Rotavirus nsP3 controls cellular and viral mRNA translation" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Sean Whelan (Harvard University School of Medicine)
"Messenger RNA cap formation serves as a key regulator of gene expression in vesicular stomatitis virus" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Wen Chang (Academia Sinica)
"Vaccinia virus and cell interactions" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Zulfiya Orynbayeva (Ben Gurion University)
"Mechanisms of internalization of the viral envelope into host cells studied by new chromatic vesicle and cell sensor assays" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Renate Fuchs (Medical University of Vienna)
"Analysis of the mechanism of human rhinovirus RNA membrane translocation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Biao He (Pennsylvania State University)
"Identification of a host protein that plays a critical role in replication of non-segmented negative-stranded RNA viruses" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | DNA VIRUS TRANSCRIPTION, TRANSLATION AND REPLICATION |
| Discussion Leaders: Ian Mohr (New York University) & Debbie Spector (University of California, San Diego) |
| 7:30 pm - 7:50 pm | Robert Kalejta (University of Wisconsin, Madison)
"Inactivation of the retinoblastoma tumor suppressor in human cytomegalovirus-infected cells" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Sandra Weller (University of Connecticut)
"How herpes simplex virus commandeers the host cell chaperone and DNA damage machinery" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Blossom Damania (University of North Carolina)
"Activation of angiogenesis by Kaposi’s sarcoma-associated herpesvirus (KSHV)" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Matthew Weitzman (Salk Institute)
"Viral interactions with the cellular DNA damage machinery" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | POSTER SESSION 1 |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DYNAMICS OF INTRACELLULAR TRAFFICKING |
| Discussion Leader: Michael Way (London Research Institute) |
| 9:00 am - 9:20 am | Xiaowei Zhuang (Harvard University)
"Entry and trafficking mechanism of poliovirus by single-virus tracking" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Urs Greber (University of Zurich)
"Microtubule motors couple adenovirus transport to disassembly" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Gregory Smith (Northwestern University)
"The large herpesvirus tegument protein: an orchestrator of viral assembly, intracellular transport and neuroinvasion" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Michael Way (London Research Institute)
"Regulation of cortical actin and its role in the release of vaccinia virus" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Fasseli Coulibaly (University of Auckland)
"The atomic structure of cypovirus polyhedra" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | David Knipe (Harvard Medical School)
"Chromatin structure and the herpesvirus lytic versus latent infection decision" |
| 11:55 am - 12:00 pm | Discussion |
|
12:00 pm - 12:10 pm | Nihal Altan-Bonnet (Rutgers University)
"Application of live-cell imaging techniques to dissect the role of cellular small GTPases facilitating Coxsackievirus replication" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | April Burch (Wadsworth Center)
"Mss1, a proteasome-associated ATPase, is recruited to replication compartments and interacts with viral proteins during HSV-1 infection" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELLULAR RESPONSE TO INFECTION AND VIRUS COUNTER-RESPONSE |
| Discussion Leaders: Otto Haller (University of Freiburg) & John Hiscott (McGill University) |
| 7:30 pm - 7:50 pm | Takashi Fujita (Kyoto University)
"Sensing viruses and antiviral response" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Frank Chisari (Scripps Research Institute)
"Stealth and cunning: HBV and HCV" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Adolfo Garcia-Sastre (Mt. Sinai College of Medicine)
"De-ISGylating and de-ubiquitinating activities of viral OTU-like proteins" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Marco Colonna (Washington University)
"TLR-dependent and independent mechanisms of viral recognition" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | POSTER SESSION 2 |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CELLULAR INHIBITION OF VIRUS REPLICATION AND VIRUS COUNTERMEASURES |
| Discussion Leaders: Michelle Barry (University of Alberta) & Ganes Sen (Cleveland Clinic Foundation) |
| 9:00 am - 9:15 am | Special Topic: Otto Haller (University of Freiburg)
"Fiftieth anniversary of the discovery of interferon" |
| 9:15 am - 9:35 am | Shou-Wei Ding (University of California, Riverside)
"Small RNA-directed viral immunity in animals" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Rick Randall (University of St. Andrews)
"Interferon actions and paramyxovirus countermeasures" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Joe Sodroski (Harvard University School of Medicine)
"TRIM5alpha: Mediator of innate intracellular immunity to retroviruses" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Karen Mossman (McMaster University)
"Host response to enveloped virus particle entry" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Joanna Shisler (University of Illinois, Urbana)
"Poxvirus regulation of the NF-kappaB transcription factor" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Luis Sigal (Fox Chase Cancer Center)
"The IFN-α binding protein of ectromelia virus is essential for pathogenesis and a possible target of a novel vaccine approach" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Angus Wilson (NYU School of Medicine)
"Two sides of the same coin: Kaposi sarcoma-associated herpesvirus (KSHV) lytic switch protein RTA regulates entry and exit from the nucleus" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s)) |
| 7:30 pm - 9:30 pm | ASSEMBLY, BUDDING AND RELEASE |
| Discussion Leaders: Gabriella Campadelli-Fiume (University of Bologna) & Joel Baines (Cornell University) |
| 7:30 pm - 7:50 pm | Anette Schneemann (Scripps Research Institute)
"Assembly of multi-layered nodavirus-like particles: a new approach for the design of antitoxins and vaccines" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Alasdair Steven (NIH)
"DNA packing:Effect and cause" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Carol Carter (SUNY Stonybrook)
"Tsg101: HIV’s personal ESCRT" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Venigalla Rao (Catholic University)
"Bacteriophage T4 DNA packaging motor: structure, mechanism and speed" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | POSTER SESSION 3 |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IMMUNE RESPONSE AND PATHOGENESIS |
| Discussion Leaders: Kim Hasenkrug (NIH/NIAID/RML) & Skip Virgin (Washington University) |
| 9:00 am - 9:20 am | Troy Randall (Trudeau Institute)
"The development and function of iBALT in response to influenza" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Michaela Muller-Trutwin (Institut Pasteur)
"Non-pathogenic simian immunodeficiency virus infection in African green monkeys: the taming of the shrew" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Kathy Spindler (University of Michigan)
"Genetic analysis of mouse adenovirus pathogenesis" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Marco Vignuzzi (University of California, San Francisco)
"The role of genetic diversity in RNA virus pathogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Michael Rossman (Purdue University)
"Flavivirus neutralizing antibody |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Michaela Gack (Harvard Medical School NEPRC)
"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-1 mediated antiviral activity" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Gjus Versteeg (Leiden University Medical Center)
"ER stress and chemokine responses are induced during coronavirus infection, yet type I interferon upregulation is prevented" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Willy Valdivia-Granda (Orion Biosciences)
"Genomic barcoding of encephalitic and hemorrhagic viral diseases" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | EVOLUTION, EPIDEMIOLOGY, PREVENTION AND THERAPY |
| Discussion Leaders: Andrew Davison (University of Glasgow) & Francine McCutchan (Jackson Foundation) |
| 7:30 pm - 7:50 pm | Mark Young (Montana State University)
"Evolutionary and ecological insights from archaeal viruses from Yellowstone’s high temperature environments" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Claude Fauquet (Danforth Plant Science Center)
"A possible evolution scenario for geminiviruses" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Andrew Davison (University of Glasgow)
"Herpesvirus evolution" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Rich Whitley (University of Alabama, Birmingham)
"Therapy of herpes simplex virus infections: where to from here?" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
