| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | Pathogenesis and Immune Responses |
| Discussion Leaders: Lynn Enquist (Princeton University) and Don Ganem (Novartis Institutes for Biomedical Research) |
| 7:35 pm - 7:55 pm | Keynote Presentation: Charles Rice (Rockefeller University)
"Antiviral actions of type I interferon-stimulated genes" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Michael Diamond (Washington University School of Medicine)
"Mechanisms of innate immune control of West Nile virus" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Klaus Früh (Oregon Health & Science University)
"Immune evasion by cytomegalovirus: Challenges and opportunities for vaccine development" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Ashley Haase (University of Minnesota)
"The paradoxical ill effects of the immune response in HIV and SIV infections" |
| 9:25 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Virus Discovery, Evolution, and Fitness |
| Discussion Leaders: Ann Palmenberg (University of Wisconsin, Madison) and Julie Pfeiffer (UT Southwestern) |
| 9:00 am - 9:20 am | David Wang (Washington University School of Medicine)
"Metagenomic approaches to viral discovery" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sara Sawyer (University of Texas, Austin)
"Probing the genetic barriers that prevent animal viruses from infecting humans" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break / Group Photo |
| 10:30 am - 10:50 am | Mark Denison (Vanderbilt University)
"Evidence for an RNA virus proofreading machine: Replication infidelity of coronavirus exonuclease mutants" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Raul Andino (UCSF)
"Poliovirus: Diversity, mutational robustness, and evolvability" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Oren Kobiler (Princeton University)
"A limited number of alpha herpesviruses genomes initiates replication in distinct nuclear compartments" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Deborah Lenschow (Washington University School of Medicine)
"ISG15, independent of UbE1L-mediated conjugation, is critical in the control of Chikungunya virus infection" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Erik Barton (Wake Forest University)
"Subversive cooperation between an oncogenic gammaherpesvirus and interferon regulatory factor 2 promotes latency and controls viral reactivation" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | Receptors and Signaling |
| Discussion Leaders: Ari Helenius (ETH Zurich) and Thilo Stehle (Universität Tübingen, Germany) |
| 5:30 pm - 5:50 pm | Ten Feizi (Imperial College London)
"The impact of carbohydrate microarrays on the molecular dissection of pathogen-host interactions" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Carolyn Coyne (University of Pittsburgh)
"The signaling orchestra elicited by picornavirus cell entry" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Bala Chandran (Chicago Medical School, Rosalind Franklin University of Medicine and Science)
"Temporal interactions of Kaposi's sarcoma associated herpesvirus with functionally related cell surface molecules - platform for signal induction" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Lucas Pelkmans (ETH Zurich and 3V Biosciences, East Palo Alto, CA)
"Signaling induced by simian virus 40 reveals a new pathway to achieve transient uncoupling of cortical actin with the plasma membrane" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| 9:30 pm | Poster Session A |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Entry and Assembly |
| Discussion Leaders: Margaret Kielian (Albert Einstein College of Medcine) and Robert Lamb (Northwestern University) |
| 9:00 am - 9:20 am | Felix Rey (Institut Pasteur, Paris)
"Class II viral fusion proteins: Insights into their activation mechanism" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Gary Nabel (NIH-NIAID)
"Conserved structures required for HIV-1 entry: The key to an AIDS vaccine" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Judith White (University of Virginia)
"Ebolavirus entry into cells" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Billy Tsai (University of Michigan)
"How polyomaviruses enter and penetrate host membranes to cause disease" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Winfried Weissenhorn (Grenoble University, France)
"Getting in and out: New insights for HIV-1" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Emily Bruce (University of Cambridge, United Kingdom)
"The cellular Rab11 pathway is involved in late stages of influenza virus assembly and budding" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Kartik Chandran (Albert Einstein College of Medcine)
"The Niemann-Pick C1 protein is a critical endosomal host factor for filovirus entry" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | Translational Control |
| Discussion Leaders: James Alwine (University of Pennsylvania) and Ian Mohr (New York University) |
| 5:30 pm - 5:50 pm | Sunnie Thompson (University of Alabama at Birmingham)
"Mechanisms of viral IRES-mediated translation" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Lyubov Ryabova (Université de Strasbourg, France)
"Polycistronic translation in cauliflower mosaic virus" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Felicia Goodrum (University of Arizona)
"Translational regulation of CMV gene expression" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Yolanda Revilla (Universidad Autónoma de Madrid-CSIC, Spain)
"African swine fever virus and control of host translation" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| 9:30 pm | Poster Session B |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of Nuclear Functions |
| Discussion Leaders: Michael Imperiale (University of Michigan) and Thomas Stamminger (Universität Erlangen-Nürnberg, Erlangen, Germany) |
| 9:00 am - 9:20 am | Thorsten Wolff (Robert Koch Institute, Berlin, Germany)
"Exploitation of nuclear host functions by influenza viruses" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Laimonis Laimins (Northwestern University Feinberg School of Medicine)
"Human papillomavirus and the ATM DNA Damage Response" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Phil Branton (McGill University, Montreal)
"Adenovirus control of the cell cycle" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Rozanne Sandri-Goldin (University of California, Irvine)
"ICP27, a pivotal player in regulating HSV-1 gene expression" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Alessandro Marcello (International Center for Genetic Engineering and Biotechnology, Trieste, Italy)
"Spatial and temporal dynamics of RNA virus replication in live cells" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Greg Sowd (Vanderbilt University)
"A role for Bloom syndrome complex, BTR, in SV40 replication?" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Micah Luftig (Duke University Medical Center)
"An ATM/Chk2-mediated DNA damage responsive signaling pathway suppresses Epstein-Barr virus transformation of primary human B cells" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | Virus-Induced Organelles |
| Discussion Leaders: Cristina Risco (Centro Nacional de Biotecnologia, Spain) and Sean Whelan (Harvard Medical School) |
| 5:30 pm - 5:50 pm | Paul Ahlquist (University of Wisconsin, Madison)
"Structure, assembly, and function of viral RNA replication compartments" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Tero Ahola (University of Helsinki, Finland)
"Formation and intracellular transport of alphavirus replication vesicles" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Jacomine Krijnse-Locker (University of Heidelberg, Germany)
"Ultra-structural analysis of membranes modified by large DNA viruses" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Abraham Minsky (Weizmann Institute of Science, Rehovot, Israel)
"The mimivirus factory: Functional and structural aspects" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| 9:30 pm | Poster Session C |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Antivirals and Vaccines |
| Discussion Leaders: Teresa Compton (Biogen IDEC) and Diane Griffin (Johns Hopkins University) |
| 9:00 am - 9:20 am | Michael Farzan (Harvard Medical School)
"A family of interferon-inducible transmembrane proteins restrict viral entry" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Benhur Lee (UCLA)
"Broad spectrum antiviral approaches" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Coffee Break |
| 10:20 am - 10:40 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 10:40 am - 11:00 am | Katya Heldwein (Tufts University)
"Structural insights into herpesvirus cell entry" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Phil Dormitzer (Novartis Vaccines and Diagnostics)
"Optimizing vaccine antigens based on viral glycoprotein structures" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Christiane Wobus (University of Michigan)
"The role of cellular deubiquitinases during norovirus infection" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Peter White (Boehringer-Ingelheim Canada)
"Evaluation of the lipid kinase PI4KIIIalpha as an anti-HCV drug target" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Benjamin tenOever (Mount Sinai School of Medicine)
"Engineering viral tools through the exploitation of microRNAs" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:30 pm | Free Time |
| 5:30 pm - 7:30 pm | Virus Nanomachines: Structure and Catalysis |
| Discussion Leaders: Craig Cameron (Pennsylvania State University) and Stephen Harrison (Harvard Medical School) |
| 5:30 pm - 5:50 pm | Keynote Presentation: Angela Belcher (MIT)
"Viruses and nanotechnology" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Antoine van Oijen (Groningen University, The Netherlands)
"Single-particle fluorescence studies of influenza viral fusion" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | John Patton (NIH-NIAID)
"Some assembly required: Mechanism of rotavirus genome packaging and replication" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Hong Zhou (UCLA)
"CryoEM model of the human adenovirus" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |