Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Entry Mechanisms |
| Discussion Leader: Hector Aguilar-Carreno (Washington State University, USA) |
7:40 pm - 8:00 pm | Thijn Brummelkamp (Netherlands Cancer Institute, The Netherlands) "Haploid Genetics in Human Cells to Study Viral Entry" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Jason Mercer (MRC Labratory for Molecular Cell Biology, United Kingdom) "Probing Macropinosome Trafficking and Maturation with Poxviruses" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Billy Tsai (University of Michigan Medical School, USA) "A Non-Enveloped Virus Hijacks Host Disaggregation Machinery to Penetrate the Endoplasmic Reticulum Membrane" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Colin Parrish (Cornell University, USA) "Parvovirus Host Ranges and Tropisms Controlled by Variation in Receptor Interactions" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Replication Mechanisms |
| Discussion Leader: Bert Semler (University of California, Irvine, USA) |
9:00 am - 9:20 am | Raul Andino (University of California, San Francisco, USA) "RNA Virus Population Dynamics: Mechanisms of Replication and Adaptation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ralf Bartenschlager (University of Heidelberg, Germany) "On the Construction and Deconstruction of Membranous Viral Replication Factories" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Stephen Cusack (European Molecular Biology Laboratory, France) "Structure and Mechanism of Polymerases of Segmented Negative Strand RNA Viruses" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Paula Traktman (Medical College of Wisconsin, USA) "The Architecture and Choreography of Vaccinia Virus Replication" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Ting Liu (Carnegie Mellon University, USA) "A Fluidity Switch that Controls DNA State in Viruses" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Janna Bigalke (Tufts University School of Medicine, USA) "Crystal Structure of the HSV-1 Nuclear Egress Complex Suggests the Mechanism of Membrane Budding" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Rachel Fearns (Boston University School of Medicine, USA) "Mechanism
by Which a Non-Segmented Negative Sense RNA Virus Initiates Transcription or
RNA Replication" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | David Dulin (University of Oxford, United Kingdom) "Single-Molecule Studies of the RNA-Dependent RNA Polymerase from Poliovirus" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Transcription and Translation |
| Discussion Leader: Craig Cameron (Pennsylvania State University, USA) |
6:00 pm - 6:20 pm | Bernard Roizman (University of Chicago, USA) "Regulation of HSV Gene Expression During Productive Infection, Latency and Reactivation" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Benjamin Tenoever (Icahn School of Medicine at Mount Sinai, USA) "Small RNA Silencing and the Mammalian Response to RNA Virus Infection" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Ian Goodfellow (University of Cambridge, United Kingdom) "Norovirus-Medicted Decoupling of Transcription from Translation Suppresses the Innate Immune Response to Infection" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Sunnie Thompson (University of Alabama at Birmingham, USA) "What Diverse Viruses Have in Common When It
Comes to Translation Initiation" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session (continued) |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Host Response to Infection |
| Discussion Leader: Barbara Sherry (North Carolina State University, USA) |
9:00 am - 9:20 am | Michael Diamond (Washington University in St. Louis School of Medicine, USA) "New Insights into Immunity Against Arthropod-Borne Viruses" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | James Crowe (Vanderbilt University Medical Center, USA) "Structural Basis for Development of Broad and Potent Human Neutralizing Antibodies to Viruses" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | John Schoggins (The University of Texas Southwestern Medical Center, USA) "Characterizing the Landscape of Cell Intrinsic Antiviral Effectors" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Michael Malim (King's College London, United Kingdom) "Interferon-Mediated Control of HIV Infection" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Jason Upton (University of Texas at Austin, USA) "Murine Cytomegalovirus Deubiquitinase Regulates Virion Content and Contributes to MCMV Pathogenesis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Thomas Stamminger (University of Erlangen-Nürnberg, Germany) "Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Bert Semler (University of California, Irvine, USA) "Viral Use of a Human DNA Repair Enzyme During Picornavirus Infections" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tzviya Zeev-Ben-Mordehai (University of Oxford, United Kingdom) "The Elusive Conformation of Herpesvirus Glycoprotein B" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Viral Evasion Mechanisms |
| Discussion Leader: Marco Vignuzzi (Pasteur Institute, France) |
6:00 pm - 6:20 pm | Michaela Gack (Harvard Medical School, USA) "Viral Immune Evasion of RNA Sensing Pathways" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Jae Jung (University of Southern California, USA) "Host Pathogen Standoff: Nucleic Acid Sensing Versus Viral Evasion" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Matthew Weitzman (Children's Hospital of Philadelphia, USA) "Dynamic
Interactions on Virus and Host Genomes During Infection" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:40 pm | Pinghui Feng (University of Southern California, USA) "Viral Pseudo Enzymes Activates RIG-I via Deamidation to Evade Cytokine Production" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Edward Mocarski (Emory University, USA) "Role of Necroptosis Signaling in Species Restriction of Herpesviruses" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session (continued) |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Host Components in Replication |
| Discussion Leader: Nihal Altan-Bonnet (National Institutes of Health, USA) |
9:00 am - 9:20 am | Wendy Barclay (Imperial College London, United Kingdom) "Host Cell Factors that Affect Influenza Virus Replication" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ileana Cristea (Princeton University, USA) "The Antiviral Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | James Alwine (University of Pennsylvania, USA) "Human Cytomegalovirus-Mediated Coordination of Cellular Stress, Signaling and Metabolic Pathways: Production of a Viral Friendly Milieu" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Clodagh O'Shea (Salk Institute, USA) "Exploiting Viruses to Understand and Treat Cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Priya Luthra (Icahn School of Medicine at Mount Sinai, USA) "Bypassing the Interferon Antagonist Function of Ebola Virus VP35 with Activators of the DNA Damage Responses" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | David Gordon (University of California, San Francisco, USA) "The Genetic Interaction Landscape of HIV Infection in Human Cells" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Sharon Hopcraft (Icahn School of Medicine at Mount Sinai, USA) "Selection of a Hepatitis C Virus with Altered Entry Factor Requirements Reveals a Genetic Interaction Between the E1 Glycoprotein and Claudins" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Patricia Resa-Infante (Heinrich Pette Institute, Germany) "Targeting Importin-α7 as a Therapeutic Approach Against Pandemic Influenza Viruses" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Pathogenesis |
| Discussion Leader: Julie Pfeiffer (The University of Texas Southwestern Medical Center, USA) |
6:00 pm - 6:20 pm | Adolfo Garcia-Sastre (Icahn School of Medicine at Mount Sinai, USA) "Role of TRIM Proteins in Innate Immunity" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Stephanie Karst (University of Florida, USA) "Norovirus Interactions with B Cells and Enteric Bacteria" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | David Knipe (Harvard Medical School, USA) "Foreign DNA Sensing, Innate Immunity, and Epigenetic Regulation of Lyric and Latent Herpesviral Gene Expression" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Michael Farzan (The Scripps Research Institute, USA) "eCD4-Ig Provides Durable Protection from SHIV in Rhesus Macaques" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session (continued) |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Viral Oncogenesis |
| Discussion Leader: Cary Moody (University of North Carolina at Chapel Hill, USA) |
9:00 am - 9:20 am | Denise Galloway (Fred Hutchinson Cancer Research Center, USA) "ALTO, a Middle T Antigen-Like Protein of Merkel Cell Polyomavirus (MCPyV)" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Nancy Raab-Traub (University of North Carolina at Chapel Hill, USA) "Epstein Barr Virus: Novel Mechanisms of Oncogenesis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Linda Van Dyk (University of Colorado, Denver, USA) "Multifunctional Non-Coding RNAs Regulate Acute and Chronic Gammaherpesvirus Infection" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Thomas Schulz (Hannover Medical School, Institute of Virology, Germany) "Insights into the Assembly and Function of Nuclear Speckles Formed by Kaposi Sarcoma Herpesvirus LANA" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Alison Ashbrook (Vanderbilt University, USA) "Antagonism of the Sodium-Potassium ATPase Restricts Chikungunya Virus Infection" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Shirit Einav (Stanford University, USA) "AAK1 and GAK Regulate Intracellular Viral Trafficking and Are Potential Targets for Broad-Spectrum Antivirals" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Esther Ndungo (Albert Einstein College of Medicine, USA) "Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing an Achilles Heel for Broadly Neutralizing Antibodies" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Vineet Menachery (University of North Carolina, USA) "SARS-Like Coronaviruses Isolate from Bat Populations Maintain Robust Emergence and Pathogenic Potential" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Vaccines and Antivirals |
| Discussion Leader: Grant McFadden (University of Florida, USA) |
6:00 pm - 6:20 pm | Heinz Feldmann (National Institute of Allergy and Infectious Diseases, NIH, USA) "Ebola: Treatment and Vaccination for an Emerging Threat" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Karla Kirkegaard (Stanford University School of Medicine, USA) "Suppressing RNA Virus Diversity and Spread" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Dong Yu (Novartis, USA) "The Progress in Subunit and RNA-Based Vaccinology, Using CMV" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Dirk Dittmer (University of North Carolina at Chapel Hill, USA) "Targeting the Myddosome for Viral Cancer Therapy" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
9:30 pm | Poster Session (continued) |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |