Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Virus Structure and Entry
Discussion Leaders: Michael Imperiale (University of Michigan, USA) and Roberto Cattaneo (Mayo Clinic College of Medicine, USA)
7:40 pm - 8:00 pm
Sean Whelan (Harvard Medical School, USA)
"Structure and Inhibition of the Replication Machinery of Negative Sense RNA Viruses"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Richard Longnecker (Northwestern University, USA)
"Epstein-Barr Virus Entry"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Felix Rey (Institut Pasteur, France)
"Class II Membrane Fusion Proteins in Viruses and Cells: Implications for Eukaryotic Evolution"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Ari Helenius (ETH Zurich, Switzerland)
"Influenza Virus Capsid Uncoating"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Immune Response to Viral Infection
Discussion Leaders: Carolina Lopez (University of Pennsylvania, USA) and Mark Denison (Vanderbilt University Medical Center, USA)
9:00 am - 9:20 am
Herbert Virgin (Washington University School of Medicine, USA)
"Role of the Virome in Control of Immunity, and Vice Versa"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ana Fernandez-Sesma (Icahn School of Medicine at Mount Sinai, USA)
"Immune Evasion Mechanisms by Flaviviruses and Beyond"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Charles Rice (The Rockefeller University, USA)
"Unraveling Nature's Intrinsic and Innate Antiviral Defenses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Gale (University of Washington, USA)
"Targeting RIG-I for Antiviral Therapy and Vaccine Adjuvant Against RNA Virus Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Benjamin Fulton (Icahn School of Medicine at Mount Sinai, USA)
"Mutagenesis of the Zika Virus Genome Defines Regions with Essential Replication and Immune Evasion Functions"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ryan Langlois (University of Minnesota, USA)
"Mechanisms Dictating Cellular Susceptibility and Resistance to Influenza A Virus Infections In Vivo "
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Nadia Martinez (Genentech, USA)
"Virus-Host Receptome Characterization for Discovery of Novel Mechanisms of Immunoregulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Jacob Yount (The Ohio State University, USA)
"IFITM3 Restriction of Virus Infection Requires an Amphipathic Helix"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral Replication and Persistence
Discussion Leaders: Andrew Pekosz (Johns Hopkins University, USA) and Laurie Krug (Stony Brook University, USA)
6:00 pm - 6:20 pm
Ronald Desrosiers (University of Miami, USA)
"Evidence for an Actual Cure of a SHIV-Infected Monkey"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Stacey Schultz-Cherry (St. Jude Children's Research Hospital, USA)
"Defining the Cellular Factors Regulating Astrovirus Replication"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Rolf Renne (University of Florida, USA)
"Long and Short Non-Coding RNAs in KSHV Biology and Pathogenesis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Carolyn Coyne (University of Pittsburgh, USA)
"Breaking Barriers: Viral Infections of Polarized Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Viral Pathogenesis
Discussion Leaders: Lynn Enquist (Princeton University, USA) and Matthew Evans (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:20 am
Julie Overbaugh (Fred Hutchinson Cancer Research Center, USA)
"Immune Responses to HIV in Mothers and Their Infants"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Lisa Ng (Singapore Immunology Network (SIgN), A*STAR, Singapore)
"Cell and Molecular Mechanisms of Alphavirus Pathogenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Martha Clokie (University of Leicester, United Kingdom)
"Bacteriophages to Treat Antibiotic Resistant Bacteria"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christiane Wobus (University of Michigan Medical School, USA)
"Modulation of Cellular Deubiquitinases Alters Macrophage Functions and Blocks Norovirus Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Andrew Mehle (University of Wisconsin-Madison, USA)
"Repurposing Canonical Antiviral Responses to Promote Viral Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Craig McCormick (Dalhousie University, Canada)
"Translation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Gene Products Is Resistant to mTORC1 Inhibition"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Enzo Poirier (Pasteur Institute, France)
"Defective Genome Production Tunes Viral Load and Persistence Through RNA Interference Activation in Arthropods"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Paul Duprex (Boston University, USA)
"Delineating Morbillivirus Entry, Dissemination and Transmission by Studying In Vivo Competition of Multicolor Canine Distemper Viruses in Ferrets"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Virus-Host Interactions
Discussion Leaders: Chris Sullivan (University of Texas at Austin, USA) and Donna Neumann (LSU Health Sciences Center New Orleans, USA)
6:00 pm - 6:20 pm
Kanta Subbarao (WHO Collaborating Centre for Reference and Research on Influenza, Australia)
"Viral and Host Determinants of Influenza Virus Transmission"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Rozanne Sandri-Goldin (University of California, Irvine, USA)
"Structure-Function Analysis of a Signature Multifunctional Herpesvirus Protein"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Nels Elde (University of Utah, USA)
"Viral Adaptation Through Retrotransposition"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Marta Gaglia (Tufts University School of Medicine, USA)
"Transcriptome-Wide Analysis of Targets of the Influenza RNase PA-X Reveals Specificity for Functional and Structural Classes of RNAs"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Rossana Colon-Thillet (Fred Hutchinson Cancer Research Center, USA)
"An Unbiased Approach to Evaluate the Contribution of Rapidly Evolving Sites at Antiviral Interfaces"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Virus Biology
Discussion Leaders: Britt Glaunsinger (University of California, Berkeley, USA) and Micah Luftig (Duke University Medical Center, USA)
9:00 am - 9:20 am
Joan Steitz (Yale University, USA)
"Viral Noncoding RNAs: More Surprises"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Carla Saleh (Pasteur Institute, France)
"Small RNA Pathways and Arboviral Persistence in Mosquitoes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Felicia Goodrum (University of Arizona, USA)
"Cytomegalovirus Regulation of Membrane Trafficking and Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Adam Lauring (University of Michigan, USA)
"A Speed-Fidelity Trade-Off Determines the Mutation Rate and Virulence of an RNA Virus"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Emma Abernathy (Stanford University, USA)
"Poliovirus Utilizes Key Components of the Autophagy Pathway While Bypassing Others"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Andreas Puschnik (Stanford University, USA)
"Genetic Dissection of Flaviviridae Host Factors Through Genome-Scale CRISPR Screens"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Emmanuelle Genoyer (University of Pennsylvania, USA)
"Mechanisms and Consequences of Intracellular Distribution of Sendai Virus Genome Species"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Seema Lakdawala (University of Pittsburgh, USA)
"Genome-Wide Analysis of Influenza Viral RNA and Nucleoprotein Architecture"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Gisa Gerold (Institute for Experimental Virology, TWINCORE, Germany)
"Identification of Two Host Enzymes as Entry Factors for Hepatitis C Virus and Plasmodium Sporozoites"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral Modulation of Host Immunity
Discussion Leaders: Melanie Brinkmann (Helmholtz Centre for Infection Research, Germany) and Stacy Horner (Duke University Medical Center, USA)
6:00 pm - 6:20 pm
Soren Paludan (University of Aarhus, Denmark)
"Evasion of Innate Immune Responses by Viruses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Ralph Baric (University of North Carolina at Chapel Hill, USA)
"Identification of Novel Viral and Host Genetic Elements Impacting Coronavirus Pathogenesis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Joanna Shisler (Univeristy of Illinois at Urbana-Champaign, USA)
"Comparative Biology of Poxvirus Immune Evasion Genes to Learn About Virus Biology"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Judy Brown (Vanderbilt University / University of Pittsburgh, USA)
"Reovirus Abrogates Immunological Tolerance to Orally Fed Antigen"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Christine Vazquez (Duke University, USA)
"Identification of a Riplet-Dependent, RIG-I-Independent Antiviral Response Regulated by Hepatitis C Virus"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Viruses and Cancer
Discussion Leaders: Robert Yarchoan (National Cancer Institute, NIH, USA) and Jae Jung (University of Southern California, USA)
9:00 am - 9:20 am
Yuan Chang (University of Pittsburgh, USA)
"MCV Small T Antigen and the Mitotic Environment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Erle Robertson (University of Pennsylvania, USA)
"EBV Regulation of Bcl6: Insights into Viral Mediated Lymphomagenesis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Laimonis Laimins (Northwestern University, USA)
"Human Papillomaviruses and DNA Damage Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ethel Cesarman (Weill Cornell Medicine, USA)
"Targeting Viral Oncogenic Signals"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jessica Tucker (University of California, Berkeley, USA)
"The Role of Retrotransposon Stimulation During Reactivation of Latent Gammaherpesvirus"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Cary Moody (University of North Carolina at Chapel Hill, USA)
"Trimethylation of Histone H3 on Lysine 36 Is Required for Productive Replication of HPV-31"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Benjamin Gewurz (Brigham and Women's Hospital, USA)
"CRISPR/Cas9 Screens for Synthetic Lethal Targets in EBV-Transformed B-Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Dean Kedes (University of Virginia, USA)
"The KSHV Episome-Host Chromatin Synapse: Elucidation of Nanoscale Architecture"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral Therapeutics and Vaccines
Discussion Leaders: Terence Dermody (University of Pittsburgh, USA) and Sankar Swaminathan (University of Utah, USA)
6:00 pm - 6:20 pm
Matthais Gromeier (Duke University Medical Center, USA)
"Cytotoxic and Immunogenic Mechanisms of Oncolytic Poliovirus"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Matthew Frieman (University of Maryland, USA)
"Pathogenesis and Therapeutic Treatment of the MERS Coronavirus"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
David Bloom (University of Florida College of Medicine, USA)
"In Vivo Knock-Down of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Reactivation from Latency"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Matthew Pennington (Cornell University, USA)
"Exploring the Antiviral Mechanism and Anti-Angiogenic Effects of Raltegravir During Feline Herpesvirus (FHV-1) Infection of Primary Feline Corneal Epithelial Cells"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure