Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Egress, Transmission and Entry
Discussion Leaders: Katya Heldwein (Tufts University School of Medicine, USA) and Margaret Kielian (Albert Einstein College of Medicine, USA)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Rebecca Dutch (University of Kentucky, USA)
"Human Metapneumovirus Replication and Spread"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Bentley Fane (University of Arizona, USA)
"The Structural Basis of Host-Virus Interactions Governing Host Range, Attachment, Eclipse and Productive DNA Transport"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Yizhi Jane Tao (Rice University, USA)
"Orsay Virus Replication in C. elegans "
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Timothy Kowalik (University of Massachusetts Medical School, USA)
"CRISPR Screens Identify OR14I1 as a Receptor for the Human Cytomegalovirus Pentameric Complex and Defines Epithelial Cell Tropism"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication Mechanisms
Discussion Leaders: Ana Fernandez-Sesma (Icahn School of Medicine at Mount Sinai, USA) and David Kushner (Dickinson College, USA)
9:00 am - 9:20 am
Jan Carette (Stanford University, USA)
"Genetic Dissection of Viral Pathogenesis and Host Defense"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andrea Gamarnik (Fundación Instituto Leloir, Argentina)
"New Mechanisms of Counteracting the Host Antiviral Response by Dengue Virus NS5 Protein"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Takeshi Kobayashi (Research Institute for Microbial Diseases, Osaka University, Japan)
"The Application of Reverse Genetics Systems in Studies of dsRNA Virus Replication and Pathogenesis"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Joseph Ziegelbauer (National Cancer Institute, NIH, USA)
"Functions of Human and Viral Circular RNAs"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Karim Majzoub (INSERM / Université de Strasbourg, France)
"An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Mandy Muller (University of Massachusetts Amherst, USA)
"A Novel RNA Element Confers Protection Against Multiple Viral Endonucleases"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ieva Bagdonaite (University of Copenhagen, Denmark)
"Probing the Functions of Glycosylation in Herpesvirus Biology Using a Glycoengineered Cell Library"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Cara Pager (University at Albany, SUNY, USA)
"Dimethylcytosine Epitranscriptomic Marks on the Hepatitis C Virus Genome Modulate Replication"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Okikiola Olajide (University of Freiburg, Germany)
"Mapping Protein Interactions with Mammalian Cells with an Expanded Genetic Code"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Carla Saleh (Institut Pasteur, France) and Blossom Damania (University of North Carolina at Chapel Hill, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Regulation of Gene Expression
Discussion Leaders: Nicholas Conrad (University of Texas Southwestern Medical Center, USA) and Laimonis Laimins (Northwestern University, USA)
6:00 pm - 6:20 pm
Demian Cazalla (University of Utah, USA)
"Functions of Viral Non-Coding RNAs in the Regulation of Gene Expression"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Victoria D'Souza (Harvard University, USA)
"Unraveling Viral RNA Genomes: One Segment at a Time"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Joanna Parish (University of Birmingham, United Kingdom)
"Co-ordination of Virus and Host Transcription Control by Oncogenic Human Papillomavirus"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Derek Walsh (Northwestern University, USA)
"Nuclear Rotation During Virus Infection"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cell Biology of Viral Infection
Discussion Leaders: Carolyn Coyne (University of Pittsburgh, USA) and Felicia Goodrum (University of Arizona, USA)
9:00 am - 9:20 am
Michael Lagunoff (University of Washington, USA)
"Cellular Pathways Required for Kaposi's Sarcoma Herpesvirus Latency"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Cristina Risco Ortiz (National Center for Biotechnology (CNB), CSIC, Spain)
"Imaging the Biogenesis of Virus Factories"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Gregory Smith (Northwestern University, USA)
"Decoding the Alpha-Herpesvirus Neuroinvasive Program"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Wesley Sundquist (University of Utah, USA)
"The ESCRT Pathway in HIV Budding and Cell Division"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Anthony Lentscher (University of Pittsburgh, USA)
"Chikungunya Virus Replication in Skeletal Muscle Is Required for Development of Inflammation and Disease"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Mojgan Naghavi (Northwstern University, USA)
"HIV-1 Capsid Coordinates Early Steps of Infection Through Mimicry of Microtubule Regulators"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Chelsey Spriggs (University of Michigan, USA)
"The BICD2-BICDR1 Dynein Cargo Adaptors Drive SV40 Disassembly to Promote Viral Entry"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
William Jackson (University of Maryland Medical Center, USA)
"How Picornaviruses Re-Wire the Autophagy Pathway for Virus Release"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathogenesis
Discussion Leaders: Laura Hertel (Children's Hospital Oakland Research Institute (CHORI), USA) and Stephanie Karst (University of Florida, USA)
6:00 pm - 6:20 pm
Yoshihiro Kawaoka (University of Tokyo, Japan / University of Wisconsin-Madison, USA)
"Pathogenesis and Transmission of Negative Strand RNA Viruses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Jason Smith (University of Washington, USA)
"Defensins in Viral Infection and Pathogenesis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Alexander Khromykh (The University of Queensland, Australia)
"Advanced Molecular Approaches to Study Flavivirus-Host Interactions"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Anthony Dawson (University of Wisconsin-Madison, USA)
"Phosphorylation Regulates Influenza Virus Polymerase Function"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Lívia Yamashiro (University of California, Berkeley, USA)
"Type I Interferon-Independent STING Signaling Contributes to Control of HSV-1 Infection In Vivo "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Host Response and Immunity
Discussion Leaders: Carla Saleh (Institut Pasteur, France) and Sabra Klein (Johns Hopkins Bloomberg School of Public Health, USA)
9:00 am - 9:20 am
Klaus Frueh (Oregon Health & Science University, USA)
"The Unique Immune Biology of Cytomegalovirus"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Marjolein Kikkert (Leiden University Medical Center, The Netherlands)
"How Viruses Interact with the Ubiquitin-Regulated Innate Immune Response"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Vera Tarakanova (Medical College of Wisconsin, USA)
"Gammaherpesvirus-Host Interactions: From Monkeys to Mice (to Humans?)"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Nicholas Heaton (Duke University, USA)
"Negative Regulation of the Innate Response as a Controller of Viral Pathogenesis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Marlene Dreux (CIRI, INSERM U1111 / Université de Lyon, France)
"Antiviral Response by Plasmacytoid Dendritic Cells via Interferogenic Synapse with Infected Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Kathryn Carpentier (University of Colorado School of Medicine, USA)
"Scavenger Receptors on Liver Phagocytes Mediate Clearance of Blood-Borne Alphaviruses Through Recognition of Modified Lysine Residues in Viral Glycoproteins"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kishana Taylor (University of California, Davis, USA)
"High Frequency of Reassortment Among Diverse Influenza Viruses Revealed by High-Throughput Experimental Coinfection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Lori Frappier (University of Toronto, Canada)
"An Epstein-Barr Virus Protein Preserves Viral Genome Integrity by Neutralizing Cellular APOBEC3B"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kirsten Kulcsar (University of Maryland School of Medicine, USA)
"Comorbid Diabetes Results in Accelerated Virus Dissemination and Enhanced Disease Following MERS-CoV Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evolution and Discovery
Discussion Leader: Sam Díaz-Muñoz (University of California, Davis, USA)
6:00 pm - 6:20 pm
David Wang (Washington University School of Medicine in St. Louis, USA)
"Functional Conservation of Proviral Factors from Worm to Humans"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Moriah Szpara (Pennsylvania State University, USA)
"Impacts of Genetic and Phenotypic Diversity in Herpes Simplex Virus Infections"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Anice Lowen (Emory University School of Medicine, USA)
"Contributions of Incomplete Genomes of Influenza A Virus to Viral Propagation and Diversification"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Joseph Bondy-Denomy (University of California, San Francisco, USA)
"How Bacteriophages Protect Themselves from CRISPR"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Antiviral Systems
Discussion Leaders: James Alwine (University of Pennsylvania School of Medicine, USA) and Amy Kistler (Chan Zuckerberg Biohub, USA)
9:00 am - 9:20 am
Sarah Butcher (University of Helsinki, Finland)
"New Thermophilic Lipid Containing Bacteriophage Structure and Host Proteome Analysis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kim Seed (University of California, Berkeley, USA)
"How Epidemic Vibrio cholerae Defends Against Viral Attack"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Tiffany Reese (University of Texas Southwestern Medical Center, USA)
"Mechanisms Governing Gammaherpesvirus Latency and Reactivation"
10:50 am - 11:00 am
Discussion
11:00 am - 11:10 am
Shan-Lu Liu (The Ohio State University, USA)
"Lentiviral Nef Proteins Antagonize TIM-Mediated Inhibition of HIV-1 Release: Role of SERINCs"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Lisa Selzer (Stanford University, USA)
"How Influenza 'Falls Apart': pH-Induced Changes of the Influenza A Virus Matrix Layer"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Nora-Guadalupe Ramirez (University of Texas Southwestern Medical Center, USA)
"A Gain-of-Function Screen Reveals Novel Human Factors Involved in T Cell-Mediated Immunity that Are Co-Opted by Exogenous Retroviruses to Thrive"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Joanna Sztuba-Solinska (Auburn University, USA)
"Lnc-ing Viral RNA Structure to Function During KSHV Infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Susan Weiss (University of Pennsylvania, USA)
"Zika Virus Resistance to the Antiviral 2',5'-Oligoadenylate Synthetase/Ribonuclease L (OAS/RNase L) Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Alexander Price (Children's Hospital of Philadelphia, USA)
"Double-Stranded RNA During Adenovirus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Evasion Strategies
Discussion Leader: Matthew Daugherty (University of California, San Diego, USA)
6:00 pm - 6:20 pm
Paul Bieniasz (The Rockefeller University, USA)
"Intrinsic Antiviral Activities"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Blossom Damania (University of North Carolina at Chapel Hill, USA)
"Interactions of KSHV with the Host"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Carolina Lopez (University of Pennsylvania, USA)
"Defective Viral Genomes During RSV Infection"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Moona Huttunen (MRC-LMCB, UCL, United Kingdom)
"ESCRT Machinery in Poxvirus Wrapping and Egress"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Roberto Cattaneo (Mayo Clinic , USA)
"Cyclical Adaptation of Measles Virus Quasispecies to Epithelial and Lymphocytic Cells: To V, or Not to V"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure