Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Entry and Egress
Discussion Leader: Jonathan Abraham (Harvard Medical School, United States)
7:40 pm - 8:00 pm
Hector Aguilar-Carreno (Cornell University, United States)
"Emerging Virus Glycoproteins: From Viral Entry to Vaccines and Antivirals"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Nicole Tischler (Fundación Ciencia & Vida - Universidad San Sebastián, Chile)
"The Hantavirus Gn/Gc Spikes During Cell Entry and Transmission: A Balance Act of Molecular Transitions"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Chelsey Spriggs (University of Michigan, United States)
"Elucidating the Cellular Entry Requirements of Merkel Cell Polyomavirus"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Moona Huttunen (University of Jyvaskyla, Finland, Finland)
"Vaccinia Virus Hijacks ESCRT-mediated Multivesicular Body Formation for Virus Egress"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Tiffany Reese (University of Texas Southwestern Medical Center, United States)
"Norovirus MLKL-like Pore Forming Protein Initiates Programmed Cell Death for Viral Egress"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Virus Host Interactions
Discussion Leaders: Carolina Arias (Chan Zuckerberg BioHub, United States) and Maya Shmulevitz (University of Alberta, Canada)
9:00 am - 9:20 am
Urs Greber (University of Zurich, Switzerland)
"Cell-to-Cell Heterogeneity - Virus Entry, Persistence and Lytic Infection"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Christopher Sullivan (University of Texas at Austin, United States)
"Noncoding RNA and Triphosphate Balance in Virus Infection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Peter James Mullen (University of Southern California, United States)
"Transcriptional Control of Nutrient Sensing in Viral Infections"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Hannah Itell (Fred Hutchinson Cancer Research Center, United States)
"Host Cell Glycosylation Differentially Affects CCR5- and CXCR4-Tropic HIV-1 Infection"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mary Estes (Baylor College of Medicine, United States)
"Unexpected Virus-host Interactions that Enable Human Norovirus Entry and Replication in Intestinal Organoids"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Keir Balla (Chan Zuckerberg Biohub, United States)
"Illuminating Virus Infection Biology in Toto with Zebrafish"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Tem Morrison (University of Colorado School of Medicine, United States)
"Species-Specific MARCO-virus Interactions Dictate Chikungunya Virus Viremia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jordan Becker (University of Minnesota - Twin Cities, United States)
"Mammalian ZAP and KHNYN Restrict CpG-enriched Avian Viruses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Yentli Soto Albrecht (University of Pennsylvania and Children's Hospital of Philadelphia, United States)
"Deficits in Mitochondrial Oxidative Phosphorylation Enhance SARS-CoV-2 Replication"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Julie Pfeiffer (The University of Texas Southwestern Medical Center, United States) and Chelsey Spriggs (University of Michigan, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Viral Evolution and Adaptation
Discussion Leader: Albert Bosch (University of Barcelona, Spain)
6:00 pm - 6:20 pm
Julie Pfeiffer (The University of Texas Southwestern Medical Center, United States)
"A Single Mutation in an Enteric Virus Alters Tropism and Sensitivity to Microbiota"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Theodora Hatziioannou (Rockefeller University, United States)
"SARS-CoV-2 vs Antibodies: You Win Some You Lose Some"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jesse Bloom (Fred Hutchinson Cancer Center, United States)
"Interpreting the Evolution of SARS-CoV-2"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Sofia Moraes (University of Minnesota, United States)
"Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Gonzalo Moratorio (Institut Pasteur de Montevideo- Universidad de la República, Uruguay., Uruguay)
"Constraining Arboviruses to Their Arthropod Vectors"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Replication and Cellular Reorganization
Discussion Leaders: Nonia Pariente (PLOS Biology, United Kingdom) and Mojgan Naghavi (Northwstern University, United States)
9:00 am - 9:20 am
Beate Sodeik (Hannover Medical School, Germany)
"Assembly of the Phage Nucleus During Bacteriophage Replication"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ileana Cristea (Princeton University, United States)
"Infection-driven Rewiring of Membrane Contact Sites for Pro-Viral Organelle Remodeling"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
David Aponte-Diaz (UNC-Chapel Hill, United States)
"Contributions of an Enteroviral Genome Replication Protein to Formation and Dynamics of the Virus-Assembly Organelle"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Kira Griswold (University of Pittsburgh, United States)
"Transneuronal Dissemination of Mammalian Orthoreovirus"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stanley Lemon (UNC Chapel Hill, United States)
"Host Factors in Hepatovirus Replication"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Zihan (Amanda) Zhu (University of Oxford, United Kingdom)
"In Vitro Reconstitution of Influenza Virus Genome Replication"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Jeremy Keown (University of Oxford, United Kingdom)
"Structural and Functional Characterization of the Hantaan Virus Polymerase Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Alexander Price (Children's Hospital of Philadelphia, United States)
"Viral Manipulation of Cellular RNA Binding Proteins through Inhibition of Arginine Methylation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Lori Frappier (University of Toronto, Canada)
"Changes in SUMO-Modified Proteins in Epstein-Barr Virus Infection Identifies Reciprocal Regulation of the TRIM24/28/33 Complex and the Lytic Switch BZLF1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Gene Regulation
Discussion Leader: Mandy Muller (University of Massachusetts Amherst, United States)
6:00 pm - 6:20 pm
Ian Mohr (New York University School of Medicine, United States)
"Post-Transcriptional Control of Gene Expression Tunes HCMV Reproduction to Physiological Stress Responses"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Shira Weingarten-Gabbay (The Broad Institute of MIT and Harvard, United States)
"Systematic Discovery of Thousands of ORFs in 700 Human Viruses"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
John Karijolich (Vanderbilt University School of Medicine, United States)
"RNA Binding Protein Discovery and Function in Herpesviruses"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Marta Gaglia (University of Wisconsin Madison, United States)
"A host shutoff RNase displays sequence-driven viral self/non-self discrimination"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Hengli Tang (Florida State University, United States)
"Zika Virus Infection Leads to Induction of a R-Loop Signature in Human Neural Cells that Contributes to Growth Attenuation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Noam Stern-Ginossar (The Weizmann Institute of Science, Israel)
"A Virally Encoded Knock Out System Provides Fundamental Insights into Cytomegalovirus Infection"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune System Activation and Viral Immune Evasion
Discussion Leaders: Kellie Jurado (University of Pennsylvania, United States) and Nir Drayman (University of California, Irvine, United States)
9:00 am - 9:20 am
Yan Xiang (University of Texas Health San Antonio, United States)
"A Novel Translation Control Mechanism by the Poxvirus Host Restriction Factor SAMD9"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Olivier Schwartz (Institut Pasteur, France)
"SARS-CoV-2 Omicron Variants: Fusion, Replication and Neutralization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Jessie Kulsuptrakul (Fred Hutchinson Cancer Research Institute, United States)
"A human-derived motif in CARD8 facilitates inflammasome activation via the detection of HIV-1 protease"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Andrew Mehle (University of Wisconsin-Madison, United States)
"Sensing of Self DNA Amplifies Innate Immune Responses to Suppress Influenza Virus Replication"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Karen Maxwell (University of Toronto, Canada)
"Exploring the Dark Matter of Phage Genomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Enzo Poirier (Institut Curie, France)
"An Isoform of Dicer Protects Mammalian Stem Cells Against Multiple RNA Viruses"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ben Gewurz (Brigham & Women's Hospital, Harvard Medical School, United States)
"An Epstein–Barr Virus Lytic Cycle Protein Interaction Map Reveals NLRP3 Inflammasome Evasion Via MAVS UFMylation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Jeremy Kamil (Louisiana State University Health Sciences Center Shreveport, United States)
"Human Cytomegalovirus Exploits the Unfolded Protein Response to Evade Antibody Responses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Derek Walsh (Northwestern University, United States)
"Novel Innate Sensing and Evasion Strategies During Poxvirus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathogenesis
Discussion Leader: Sumana Sanyal (Dunn School of Pathology, University of Oxford, United Kingdom)
6:00 pm - 6:20 pm
Eva Harris (University of California, Berkeley, United States)
"Viral Toxins: Comparative Mechanisms of Induction of Vascular Leak by Flavivirus NS1 and SARS-CoV-2 Spike Proteins"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Ilhem Messaoudi (University of Kentucky, United States)
"Mechanisms of Varicella Virus Pathogenesis and Dissemination"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Natasha Kafai (Washington University in St. Louis, United States)
"The Entry Receptor LDLRAD3 is Critical for Venezuelan Equine Encephalitis Virus Pathogenesis and Neuroinvasion in Mice"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Andrea French (University of Pittsburgh, United States)
"Tissue-Specific Host Responses are a Critical Component of the Increased Morbidity Observed During Influenza Virus and S. Pneumoniae Co-infection"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Sabra Klein (Johns Hopkins Bloomberg School of Public Health, United States)
"Biological Sex and Pregnancy Impact Influenza Outcomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Therapeutic Strategies
Discussion Leaders: Justin Richner (University of Illinois Chicago, United States) and Caroline Tapparel Vu (Faculty of Medicine/University of Geneva, Switzerland)
9:00 am - 9:20 am
David Veesler (University of Washington, United States)
"Structure-Guided Coronavirus Vaccine Design"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Volker Thiel (University of Bern, Switzerland)
"Lost in Translation - SARS-CoV-2 Attenuation by Large Scale Genome Recoding"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Khursheed Anwer (IMUNON Corporation, United States)
"A Novel DNA Vaccine Approach for Prophylactic and Therapeutic Vaccines"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Meghan Vermillion (Gilead Sciences, United States)
"Exploring Potential Indications for Remdesivir Beyond COVID-19"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kartik Chandran (Albert Einstein College of Medicine, United States)
"Discovery and Characterization of a Broadly Neutralizing Human Antibody that Affords Pan-Hantavirus Protection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Beatriz Escudero Perez (Bernhard Nocht Institute for Tropical Medicine, Germany)
"Chimeric Mouse Models to Study Emerging Zoonotic Viruses"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kristin Wiggins (St. Jude Children's Research Hospital, United States)
"Weight Loss at the Time of Vaccination Increases Influenza Vaccine Efficacy in Obese Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Joseph Trimarco (Duke University, United States)
"Targeting Host Glycosyltransferase Activity as a Broad-Spectrum Antiviral Strategy Against Influenza Viruses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Latency, Persistence and Oncogenesis
Discussion Leader: Robert Kalejta (University of Wisconsin, Madison, United States)
6:00 pm - 6:20 pm
Päivi Ojala (University of Helsinki , Finland)
"Novel Function for Key Lymphatic Transcription Factor SOX18 in KSHV Replication"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Laurie Krug (National Cancer Institute, United States)
"Oncogenic Gammaherpesvirus Reliance on STAT3 to Dampen Interferon Signaling and Support Latency in B Cells of the Host"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Elizabeth White (University of Pennsylvania Perelman School of Medicine, United States)
"Papillomavirus Oncoproteins Control Host Cell Fate"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
Micah Luftig (Duke University Medical Center, United States)
"Heterogeneous Outcomes of Epstein-Barr Virus Infection"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Christine O'Connor (Cleveland Clinic, United States)
"Host-Encoded CTCF Regulates CMV Latency via Chromatin Looping"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure