Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Frontiers in Visual System Development and Disease |
| Discussion Leaders: Nadean Brown (University of California, Davis, USA) and Graeme Mardon (Baylor College of Medicine, USA) |
7:40 pm - 8:20 pm | Patricia D'Amore (Schepens Eye Research Institute, Massachusetts Eye and Ear, USA) "Retinal Vascular Development and Pathology" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Carla Shatz (Stanford University, USA) "Saving the Synapse: Pruning, Plasticity and Amblyopia" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Model Organism Genetics in Visual System Development |
| Discussion Leader: Ruth Ashery-Padan (Tel Aviv University, Israel) |
9:00 am - 9:20 am | Hugo Bellen (Baylor College of Medicine, USA) "Pathogenic Mechanisms of Photoreceptor Neurodegeneration Associated with Mitochondrial Proteins" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:40 am | Deborah Stenkamp (University of Idaho, USA) "Retinoids and Thyroid Hormone Regulate Differential Expression of Tandemly-Replicated Cone Opsin Genes in the Zebrafish" |
9:40 am - 9:45 am | Discussion |
9:45 am - 9:55 am | Michael Perry (New York University, USA) "Butterfly Eye Evo-Devo: Stochastic Patterning and Expanded Color Vision" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Brian Link (Medical College of Wisconsin, USA) "Apical Cell Junction Remodeling Modulates Signaling During Retinal Development" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jessica Treisman (Skirball Institute of Biomolecular Medicine, NYU Langone Medical Center, USA) "Cell Fate Specification by the Glass Transcription Factor" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Joseph Brzezinski (University of Colorado School of Medicine, USA) "Regulation of Bipolar Cell Genesis" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Ryan MacDonald (University of Sheffield, United Kingdom) "Identifying the Molecular Mechanisms of Müller Glial Patterning and Morphogenesis in the Zebrafish Retina" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Seema Agarwala (University of Texas at Austin, USA) "BMP Signaling Differentially Regulates Choroid Fissure Closure Along the Proximo-Distal Axis of the Amniote Eye" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Sabine Fuhrmann (Vanderbilt University School of Medicine, USA) and Tiffany Cook (Wayne State University School of Medicine, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regenerating Vision |
| Discussion Leader: Valerie Wallace (Toronto Western Research Institute, Canada) |
7:30 pm - 7:50 pm | Sabine Fuhrmann (Vanderbilt University School of Medicine, USA) "Ventral Optic Cup Morphogenesis: Closing the Gap" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Katia Del Rio-Tsonis (Miami University, USA) "NAC: A Unique Inducer of Chick Retina Regeneration" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | W. Ted Allison (University of Alberta, Canada) "Specifying Rods and Cones - Insights from an Evo-Devo Approach" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Daniel Goldman (University of Michigan, USA) "Fgf Signaling and Retina Regeneration in Zebrafish" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Stem Cells to Organs |
| Discussion Leader: Monica Vetter (University of Utah, USA) |
9:00 am - 9:20 am | Valeria Canto-Soler (Wilmer Eye Institute, Johns Hopkins University, USA) "Retinal Organoids: Challenges and Opportunities for Pre-Clinical Applications" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Rachael Pearson (University College London, United Kingdom) "Donor and Host Photoreceptors Engage in Material Transfer Following Transplantation of Post-Mitotic Photoreceptor Precursors" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Jennifer Aparicio (Children's Hospital Los Angeles, USA) "Temporal Expression of CD184(CXCR4) and CD171(L1CAM) Identifies Distinct Early Developmental Stages of Human RGCs in Embryonic Stem Cell Derived Retina" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Nady Golestaneh (Georgetown University, USA) "Stem Cell-Based Disease Model of Age-Related Macular Degeneration" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Timothy Plageman (Ohio State University, USA) "Lens Placode Cell Anisotropic Geometry Is Mediated by Planar Polarized Inhibition of Junctional Contraction During Invagination" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Wei Liu (Albert Einstein College of Medicine, USA) "Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Guillermo Oliver (Northwestern University, USA) "Identification of New Players in the Process of Neuroretina Fate Differentiation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Anna La Torre (University of California, Davis, USA) "Reelin Signaling Termination in Retinal Lamination" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Circuitry, Synapses and Biologic Clocks |
| Discussion Leader: Claude Desplan (New York University, USA) |
7:30 pm - 7:50 pm | Sujata Rao (Cleveland Clinic, USA) "Regulation of Ocular Vasculature by a Neuronal Clock" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Jin Woo Kim (Korea Advanced Institute of Science and Technology, South Korea) "LIM Code of Visual Adaption in the Mouse Retina" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Peter Stoilov (West Virginia University, USA) "A Photoreceptor-Specific Splicing Program Controlled by Mushashi1" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Iris Selecker (The Francis Crick Institute, United Kingdom) "Astrocyte-Like Glia During Visual Circuit Assembly in Drosophila" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Steven Altschuler (University of California, San Francisco, USA) "Wiring Principles of Neural Superposition in the Fly Visual System" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ocular Disease Mechanisms |
| Discussion Leader: Shiming Chen (Washington University in St. Louis, USA) |
9:00 am - 9:20 am | Rui Chen (Baylor College of Medicine, USA) "Connecting Cilium and Photoreceptor Cell Degeneration" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Brian Perkins (Cleveland Clinic, USA) "Genetic Interactions Between the Cilia-Related Genes cep290 and arl13b Regulate the Severity of Photoreceptor Degeneration" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Joseph Corbo (Washington University School of Medicine in St. Louis, USA) "The Mechanistic Basis of Seeing (Infra)Red" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Salil Lachke (University of Delaware, USA) "Mediating CELF-Control in Eye Development" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Claudia Benavente (University of California, Irvine, USA) "Role of Epigenetics in Retinal Degeneration and Retinoblastoma" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Ryan Thummel (Wayne State University School of Medicine, USA) "A Zebrafish Model for the Vision Defects Associated with a Novel Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Brian Brooks (National Eye Institute, NIH, USA) "Nlz2 (Zfp503) Is Required for RPE Differentiation and Optic Fissure Closure" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Non-Neural Cells and Tissues |
| Discussion Leader: Ales Cvekl (Albert Einstein College of Medicine, USA) |
7:30 pm - 7:50 pm | Melinda Duncan (University of Delaware, USA) "Lens Development: Control of Cell Fate Decisions via Cross Talk Between Signal Transduction Pathways" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Markus Friedrich (Wayne State University, USA) "Adult Lens Deposition in a Cave Beetle" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Francesca Pignoni (State University of New York Upstate Medical University, USA) "The Non-Neural Tissue of the Drosophila Eye Disc: Mitf/MITF, Arm/ß-Catenin and Yki/YAP/TAZ Promote Peripodial Identity and Suppress Retina Identity" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Xin Zhang (Columbia University, USA) "Proteoglycan Regulation of Astrocyte Migration and Angiogenesis" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Conserved Mechanisms of Gene Regulation |
| Discussion Leader: William Jeffery (University of Maryland, USA) |
9:00 am - 9:20 am | Monica Vetter (University of Utah, USA) "Extrinsic and Intrinsic Modulation of Progenitor Proliferation and Differentiation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Marek Mlodzik (Icahn School of Medicine at Mount Sinai, USA) "Wnt-Frizzled Planar Cell Polarity Signaling in Photoreceptor Patterning in the Retina" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Andrea Viczian (State University of New York Upstate Medical University, USA) "Distinct Cis-Acting Regions Control Six6 Expression During Early and Late Stages of Eye Formation" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Makoto Sato (Kanazawa University, Japan) "Mathematical Modeling and Genetic Analysis of the Proneural Wave in the Fly Visual Center" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Nicholas Baker (Albert Einstein College of Medicine, USA) "The HLH Protein Network that Controls Neural Fate" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Robert Johnston (Johns Hopkins University, USA) "Natural Variation in Binding Site Affinity Controls Stochastic Gene Expression and Color Perception in Flies" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Seth Blackshaw (Johns Hopkins University School of Medicine, USA) "Molecular Mechanisms of Developmental Competence in Retinal Progenitors" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolutionary Changes to the Visual System |
| Discussion Leader: Zbynek Kozmik (Institute of Molecular Genetics, Czech Academy of Sciences, Czech Republic) |
7:30 pm - 7:50 pm | Megan Porter (University of Hawaii at Manoa, USA) "The Molecular Evolution and Development of Visual System Complexity in Stomatopod Crustaceans" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Elke Buschbeck (University of Cincinnati, USA) "Probing the Ubiquity of Developmental Patterns in a Complex Beetle Eye" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Adriana Briscoe (University of California, Irvine, USA) "Sexual Dimorphisms in Butterfly Vision: Genes, Physiology and Behavior" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | William Jeffery (University of Maryland, USA) "Evolution of Visual System Degeneration in Blind Cavefish" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |