Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Wnt Proteins: Structures and Modifications
Discussion Leader: Roeland Nusse (Stanford University, USA)
7:40 pm - 8:10 pm
Jean-Paul Vincent (Francis Crick Institute, United Kingdom)
"Secretion and Release of Wnts"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Yvonne Jones (Division of Structural Biology (STRUBI), University of Oxford, United Kingdom)
"Structural Analysis of Wnt Signaling Components"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Rami Hannoush (Genentech, Inc., USA)
"Biochemical Analysis of Wnt Signaling"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Wnt Signal Transduction
Discussion Leader: Karl Willert (University of California, San Diego, USA)
9:00 am - 9:25 am
Xi He (Harvard Medical School, USA)
"Novel Regulators of Wnt Signaling"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
William Weis (Stanford University, USA)
"Molecular Mechanisms in Wnt/β-Catenin Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Madelon Maurice (University Medical Center Utrecht, The Netherlands)
"Wnt Pathway Tumor Suppressors: Mechanisms and Mutations"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Harald Junge (University of Colorado Boulder, USA)
"Norrin-Induced Frizzled4 Endocytosis and Endo-Lysosomal Trafficking Control Retinal Angiogenesis and Barrier Function"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Wenqing Xu (University of Washington, USA)
"Structural Basis of Norrin-Mediated Wnt/Beta-Catenin Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Chris Cho (Johns Hopkins School of Medicine, USA)
"Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian Central Nervous System Angiogenesis and Blood-Brain Barrier Regulation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Karsten Melcher (Van Andel Research Institute, USA)
"Wnt5a Promotes Frizzled-4 Signalosome Assembly by Stabilizing Cysteine-Rich Domain Dimerization"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Junichi Takagi (Institute for Protein Research, Osaka University, Japan)
"Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-Glycosylation and the Binding of Wnt-Antagonist Dkk1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling at the Membrane
Discussion Leader: William Weis (Stanford University, USA)
7:30 pm - 7:55 pm
Michael Boutros (German Cancer Research Center (DKFZ), Germany)
"Secretion of Wnt Signals"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Vivian Budnik (University of Massachusetts Medical School, USA)
"Wnt Signaling in Development"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Christof Niehrs (Institute of Molecular Biology (IMB), University of Mainz, Germany)
"Novel Regulators of LRP6"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in the Nucleus and Beyond
Discussion Leader: Xi He (Harvard Medical School, USA)
9:00 am - 9:25 am
Kenneth Cadigan (University of Michigan, USA)
"Wnt Target Gene Regulation: Not All Binding Sites Are Created Equal"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Terry Yamaguchi (National Cancer Institute at Frederick, NIH, USA)
"Developmental Roles of Wnt Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
Mariann Bienz (MRC Laboratory of Molecular Biology, United Kingdom)
"On-Off Switching of the Wnt Enhanceosome"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Claudio Cantù (University of Zurich, Switzerland)
"An Ancient Tissue-Specific Transcriptional Module Drives Wnt/Beta-Catenin Signaling During Heart Development"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Lei Ji (Novartis Institutes for Biomedical Research, USA)
"The SIAH E3 Ubiquitin Ligases Promote Wnt/Beta-Catenin Signaling Through Mediating Wnt-Induced Axin Degradation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ben Major (University of North Carolina at Chapel Hill, USA)
"Competitive Kinase Enrichment Proteomics to Instruct Drug Repurposing and Circumvent Clinical Toxicity - Unexpected WNT Activators"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Yashi Ahmed (Dartmouth College, USA)
"APC Promotes Axin Phosphorylation in both the Activation and Inhibition of Wingless/Wnt Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Caroline Alexander (University of Wisconsin-Madison, USA)
"Lrp5: More than a Role in Wnt Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell Biology of Wnt Proteins and Signaling
Discussion Leader: Rami Hannoush (Genentech, Inc., USA)
7:30 pm - 7:55 pm
Ethan Lee (Vanderbilt University, USA)
"A Model for Wnt Receptor Activation by APC"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
David Virshup (Duke-NUS Medical School, Singapore)
"Wnt's Journey to the Membrane"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Stephane Angers (University of Toronto, Canada)
"Identification of FZD5 as a Genetic Vulnerability in RNF43 Mutant Cancers"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
Selected from Poster Abstracts: Yimin Zou (University of California, San Diego, USA)
"Sonic Hedgehog Is a Midline Switch for Wnt/Planar Cell Polarity Signaling in Commissural Axon Guidance"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt in Stem Cells and
Regeneration
Discussion Leader: Edward Morrisey (University of Pennsylvania, USA)
9:00 am - 9:25 am
Arial Zeng (Chinese Academy of Sciences, China)
"PROCR in Regulating Mammary Stem Cells and Beyond"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Peter Reddien (Whitehead Institute for Biomedical Research, USA)
"The Role of Wnt Signaling from Muscle in Planarian Regeneration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Selected from Poster Abstracts: Sergei Sokol (Icahn School of Medicine at Mount Sinai, USA)
"MAL Proteins Mediate Wnt Signaling During Neural Crest Specification"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Selected from Poster Abstracts: Derk Ten Berge (Erasmus Medical Center, The Netherlands)
"Wnt and MEK Signals Act Sequentially in Naïve-Primed Pluripotency Transition via an Embryonic Rosette State"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Elizabeth Vincan (University of Melbourne, Australia)
"Frizzled7 Functions as a Wnt Receptor in Gastrointestinal Epithelial Stem Cells: Implications for Cancer Growth and Progression"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Richard Dorsky (University of Utah, USA)
"Lef1-Dependent Hypothalamic Neurogenesis Inhibits Anxiety"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Stephanie Grainger (University of California, San Diego, USA)
"Independent Wnt/Fzd Signals Are Required for Hematopoietic Stem Cell Development"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Stacey Ogden (St. Jude Children's Research Hospital, USA)
"In Vitro Cytoneme Analysis Provides Insight into In Vivo Cyotneme Regulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Ryan Range (Mississippi State University, USA)
"The Emerging Wnt Signaling Network that Governs Anterior-Posterior Neuroectoderm Patterning in Sea Urchin Embryos"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Systems Biology of Wnt Signaling
Discussion Leader: Mariann Bienz (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:55 pm
Marc Kirschner (Harvard Medical School, USA)
"The Intracellular Dynamics of Disheveled and Axin at the Single Molecule Level"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Lawrence Lum (University of Texas Southwestern Medical Center, USA)
"Interrogating Wnt Signaling with the Help of Large Molecular Libraries"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Marian Waterman (University of California, Irvine, USA)
"Wnt Signaling Heterogeneity in Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt in Development
Discussion Leader: Kenneth Cadigan (University of Michigan, USA)
9:00 am - 9:25 am
Edward Morrisey (University of Pennsylvania, USA)
"Wnt Responsiveness Defines Epithelial and Mesenchymal Niches in the Adult Lung"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Bryan Phillips (University of Iowa, USA)
"Asymmetric Cell Division During Development Requires Wnt Signaling and Tight Control of β-Catenin Levels"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
Selected from Poster Abstracts: Kaitlin Basham (University of Michigan, USA)
"Wnt Inhibitor ZNRF3 Is a Critical Regulator of Adrenal Homeostasis"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
Selected from Poster Abstracts: Bo Gao (The University of Hong Kong, Hong Kong SAR China)
"Wnt-Induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Selected from Poster Abstracts: Tohru Ishitani (Institute for Molecular and Cellular Regulation, Gunma University, Japan)
"The Noise-Cancelling System Supporting Precise Wnt/β-Catenin Signaling-Mediated Vertebrate Tissue Patterning"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Akira Kikuchi (Graduate School of Medicine, Osaka University, Japan)
"The Dickkopf1-CKAP4 Axis Creates a Novel Cancer Cell Proliferation Pathway and May Represent a Therapeutic Target for Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Kibeom Kim (California Institute of Technology, USA)
"Two-Element Transcriptional Regulation in the Canonical Wnt Pathway"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Danielle Kopke (Vanderbilt University, USA)
"A Secreted HSPG Regulates Extracellular Wnt Signaling to Coordinate Synaptogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Selected from Poster Abstracts: Tuomas Tammela (Massachusetts Institute of Technology, USA)
"A Wnt-Producing Niche Maintains Proliferative Potential and Drives Tumor Progression in Lung Adenocarcinoma"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling in Disease
Discussion Leader: Michael Boutros (German Cancer Research Center (DKFZ), Germany)
7:30 pm - 7:55 pm
Matthew Warman (Boston Children's Hospital, Harvard University, USA)
"Wnt Signaling in Bone Homeostasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Bart Williams (Van Andel Research Institute, USA)
"Wnt Signaling in Skeletal Development and Homeostasis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Owen Sansom (Beatson Institute for Cancer Research, United Kingdom)
"Assessing the Impact of Wnt Inhibition on Stem Cells and Tumourigenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Vishal Deshmukh (Samumed, LLC, USA)
"Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04690) as a Potential Disease Modifying Treatment for Knee Osteoarthritis"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
